One of the greatest challenges of the 21st century is to bridge the gap from single molecules to behavior. This challenge requires a comprehensive and integrative approach, well beyond the scope of isolated research teams. It also requires the use of organisms in which the genetic underpinnings of brain function and behavior can be teased apart efficiently and in an unbiased manner. We have created a singular environment that fosters innovative neuroscience research through the integration of multiple levels of analysis in conventional invertebrate models such as Drosophila and C. elegans, as well as in unconventional models like the monarch butterfly. Research teams are highly collaborative and interactive, conducting their research in laboratories devoid of physical boundaries, and allowing a natural flow of information and expertise, which synergizes the process of discovery. This environment not only promotes exponential advances in neuroscience, but also provides a unique setting of excellence and high standards for the training of graduate students and postdoctoral fellows.