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Dual Function Vectors

Dual Function Vectors

What are dual function vectors?

Our lab is a pioneer in the development of dual function vectors, which allow the simultaneous silencing of an endogenous toxic target using an artificial miRNA, and the expression of the non-toxic variant as a transgene, or re-expression of the miRNA de-targeted variant. This is possible due to the small size of the miRNAs, which allows us to encode a miRNA and a mRNA in a single AAV vector.

 

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