Guertin Lab Published New Data About mTORC2 Signaling in Brown Adipocytes
Postdoctoral fellow Camila Martinez-Calejman, PhD, built on her recent study in the Guertin lab, published in Nature Communications, to further explore downstream mTORC2 signaling in brown adipocytes. Collaborating with a proteomics lab at the University of Washington, they examined time-dependent changes in the mTORC2 signaling pathway, following insulin stimulation in mature brown adipocytes (fat tissue).
The findings support previous work that identified ATP-citrate lyase as an mTORC2-sensitive phosphoprotein in brown adipocytes. This newly published data reveals additional interesting features of the mTORC2-regulated proteome and phospho-proteome, which may be relevant to type 2 diabetes and cancer.
The April 2020 article titled "Proteome and phosphoproteome analysis of brown adipocytes reveals that RICTOR loss dampens global insulin/AKT signaling" in the journal Molecular and Cellular Proteomics can be found here.