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    Our new publication appears in Nature: C. elegans as a model for inter-individual variation in metabolism

    Our health is greatly influenced by our genome and diet. It is difficult to study metabolic phenotypes as a function of diet and genetic variation in humans, because such studies require the collection of large sets of data under precisely controlled conditions.

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    Working together during the COVID-19 pandemic, a silver lining in a trying time

    Dr. Walhout recently wrote a post on the motivations of and the process behind our WormPaths paper (in press at Genetics). This post is featured on the Genetics Society of America “Genes to Genomes” blog. Below is an excerpt.

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    C. elegans and its bacterial diet: An interspecies model to explore the effects of microbiota on drug response

    Our body is inhabited by a large community of microorganisms referred to as our microbiota that influences almost all aspects of human physiology, including the response to thereapeutic drugs. Drugs can affect microbiota composition and the microbiota can modulate the

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    Congratulations Dr. Garcia-Gonzalez!

    Congratulations to Dr. Aurian P. Garcia-Gonzalez on successfully defending her doctoral dissertation titled, “C. elegans as a model for host-microbe-drug interactions.” Dr. Garcia-Gonzalez will return to medical school next month, and will complete her MD degree in 2021. Great job …

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    Transcriptional regulation of metabolic flux: a C. elegans perspective

    Metabolic reactions form the basis of life to generate biomass, produce energy and eliminate waste. Together, metabolic reactions function in the context of a highly interconnected metabolic network. Flux through this network needs to be adaptable depending on nutrient availability

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    Perspective: If two deletions don’t stop growth, try three

    Dr. Walhout provides perspective in the April 20 issue of Science on the latest Research Article from a longstanding collaboration between Brenda Andrews and Charles Boone at the University of Toronto, and Chad Myers from the University of Minnesota.

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    Methods: Gateway Recombinational Cloning

    The January, 2018, issue of Cold Spring Harbor Protocols features three protocols on Gateway recombinatorial cloning for use in high-throughput studies. The Gateway recombinatorial cloning system was developed for cloning multiple DNA fragments in parallel (e.g., in 96-well formats) in

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    Review: Worms, bugs and drugs: Caenorhabditis elegans as a model for host-microbe-drug interactions

    The microbiota plays a critical role in human health and disease. For instance, the gut microbiota aides in the digestion of foods, thereby contributing to our ability to metabolize compounds from our diet. Recently, it has become clear that the

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    Dr. Walhout receives $4.1 million outstanding investigator award from NIH

    Marian Walhout, PhD, has received a 5-year, $4.1 million Maximizing Investigators’ Research Award (MIRA) from the National Institutes of Health to continue her study of metabolism and gene expression and how they interact.

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    Dr. Walhout Appointed to Endowed Chair

    UMass Chan Medical School will invest three faculty members into newly endowed chairs and three more to existing endowed chairs, according to a vote by the University of Massachusetts Board of Trustees at its April 12 meeting. Marian Walhout, PhD, professor

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