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We pioneered the staging of primary erythroid progenitors by flow cytometry. This allows us to study minimally- perturbed progenitors directly within their physiological niche in vivo. We combine the staging of erythroid progenitors with new genome-wide technologies to investigate a number of inter-related areas:

cell fate decision


Activation of erythroid gene transcription: a cell fate decision orchestrated by the cell cycle



DNA Demethylation



Genome-wide loss of DNA methylation during erythroid differentiation



Systems biology



Systems Biology: Reverse engineering of the erythropoietic system



Stat5 signaling dynamics





Stat5 signaling dynamics: binary and graded signaling modalities