Overview
We pioneered the staging of primary erythroid progenitors by flow cytometry. This allows us to study minimally- perturbed progenitors directly within their physiological niche in vivo. We combine the staging of erythroid progenitors with new genome-wide technologies to investigate a number of inter-related areas:
Activation of erythroid gene transcription: a cell fate decision orchestrated by the cell cycle
Genome-wide loss of DNA methylation during erythroid differentiation
Systems Biology: Reverse engineering of the erythropoietic system
