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Our lab studies fundamental mechanisms of erythropoiesis, the process of red cell formation. 

Abnormal erythropoiesis results in anemia.

Anemia is responsible for 8.8% of all global disability, and is one of the first symptoms of cancer, already present in 40% of patients at diagnosis.

Anemia is also caused by infections, chronic diseases, nutritional dificiencies and hereditary diseases like sickle-cell anemia.

There are no good treatments for many types of anemia, including anemia associated with cancer. Anemia increases mortality and predicts poor outcome in cancer, COVID and other illnesses.

Our work identifies novel regulators of erythropoiesis, suggesting new ways of treating anemia.

Recent Publications

EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Hidalgo et al., Nature Communications 2021 https://doi.org/10.1038/s41467-021-27562-4

Population Snapshots Predict Early Hematopoietic and Erythroid Hierarchies. Tusi et al., Nature 2018; http://rdcu.be/HxCF

Global Increase in Replication Fork Speed During a p57KIP2-Regulated Erythroid Cell Fate Switch. Hwang et al., Science Advances  2017