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“To know where cancer is going you have to understand where it has been”

Our laboratory is studying how tumors, and in particular prostate and pancreatic cancers, escape immune surveillance during disease progression, and trying to restore tumor suppressive pathways lost early during tumor inception for cancer immunotherapy. We use innovative mouse modeling approaches, combined with genome editing, screening, and sequencing modalities, to dissect and manipulate tumor suppressor pathways, to elucidate tumor-immune interactions, and to evaluate new drug combinations for treating aggressive solid tumors. We are particularly interested in studying a tumor suppressive pathway called cellular senescence, a physiological stress-response program leading to proliferative arrest and secretion of pleiotropic factors that modulate immune responses.

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