Research RSS

CONCLUSIONS: CV successfully extracted objective motion metrics that differentiated POCUS skill levels between novices and experts and captured skill development over time. This approach offers a scalable, unobtrusive method for objective POCUS assessment, while supporting competency-based medical education frameworks.

CONCLUSIONS: In an analysis of the NSQIP database, 68% of cases resulted in TO. Several factors were associated with failure to achieve TO. Further investigations are needed to test if modifying variables like preoperative weight can lead to improved outcomes.

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CONCLUSION: Retrograde branches for bridging well selected renovisceral arteries and other aortic side branches were related to high technical success and good patency during midterm follow up.

BACKGROUND: Effective working relationships between drug courts and community providers are critical to improving access to medications for opioid use disorder (MOUD), but collaboration is often inadequate. We adapted and piloted a package of implementation strategies (Clinical Organizations and Legal Agency Alliance Building; COLAAB) designed to enhance collaboration between recovery courts and M...

The cohesin complex extrudes chromatin loops, stopping at sites bound by CCCTC-binding factor (CTCF) and organizing chromosomes into topologically associated domains, yet biological implications of this process remain obscure. We show that cohesin controls the in vivo differentiation and function of murine antigen-presenting dendritic cells (DCs), particularly antigen cross-presentation and interl...

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The protective correlates of Mycobacterium tuberculosis (Mtb) infection-elicited host immune responses are incompletely understood. Here, we report pro-pathogenic crosstalk involving Ly6G^(+) granulocytes (Ly6G^(+)Gra), IL-17, and COX2. We show that in the lungs of Mtb-infected wild-type mice, either BCG-vaccinated or not, most intracellular bacilli are Ly6G^(+)Gra-resident 4 weeks post-infection ...

The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucleosomes. Nucleosome remodeling complexes hydrolyze ATP to translocate DNA and thereby mobilize histone proteins. While nucleosome remodeling complexes have been extensively studied for their roles in ...

CONCLUSIONS: Among CLS-involved homeless veterans with COD, suicidality was associated with elevated criminogenic risk and greater psychiatric burden, particularly PTSD. These findings underscore the need for integrated interventions that address both criminogenic and behavioral health factors to support recovery, reduce suicide risk and mental health symptoms, and mitigate CLS recidivism.

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CONCLUSIONS: This population-based study provides evidence that multiply marginalized birthing individuals experience compounded health disparities that persist even after adjusting for sociodemographic and clinical factors. Efforts are needed to ensure that individuals with multiple marginalized identities, have access to comprehensive, accessible, disability-competent, and culturally sensitive m...

Adeno-associated virus (AAV) capsids that can confer efficient and safe gene therapy of the retina remain unmet needs. In this study, we isolated a library of natural capsids from human tissues and identified two variants that conferred strong transduction of retinal tissues following intravitreal injections of mice and non-human primates. Interestingly, the defining amino acids among the two vari...

CONCLUSIONS: Elevated DASA scores at ED triage are associated with increased use of behavioral interventions in pediatric patients, representing the first aggression prediction tool with demonstrated value in both adult and pediatric populations. Future research should examine whether proactive, DASA-guided interventions can reduce aggression risk.

The COVID-19 pandemic accelerated the development of monoclonal antibodies (mAb) targeting SARS-CoV-2, with IgG1-based mAbs dominating the therapeutic landscape. However, IgA-the predominant immunoglobulin at mucosal surfaces-represents a promising alternative for respiratory infections due to its natural role in immune exclusion and pathogen neutralization. Here, we engineered IgA-Fc fusion prote...

CONCLUSIONS: Definitive ED revision amputation was associated with a high rate of failure, need for revision surgery, and loss to follow up. Injuries with complex wound coverage or bony fixation may be better suited to OR management. Some patients may ultimately be appropriate for management without revision amputation and may be overtreated with this procedure in the ED.

Schools are pivotal in promoting physical activity (PA) among children through supportive environments and targeted programming. Despite this, in 2024, only 39% of Canadian children met PA guidelines, with inequity linked to socioeconomic status. This study describes the availability of PA activities and facilities in Quebec primary schools according to school deprivation levels and the extent to ...

Oligonucleotide therapeutics are a new class of drugs that enable robust and sustained modulation of gene expression. However, achieving efficient delivery of small interfering RNAs (siRNAs) to tumors is a challenge for therapy. Here, we demonstrate that fully chemically modified siRNAs conjugated with an albumin-binding dendrimer are efficiently delivered to both neoplastic and stromal/immune cel...

CONCLUSION: Popliteal cysts may represent a primary presenting symptom of PJI, especially when the causative organism is of low virulence, such as M. luteus.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and a major cause of end-stage renal disease. The disorder is primarily caused by pathogenic variants in PKD1 or PKD2, which encode the ciliary proteins polycystin-1 and polycystin-2. Loss of polycystin function disrupts calcium and cAMP signaling within the primary cilium, altering epithelial prolife...

Immunoisolation devices containing therapeutic protein-secreting cells offer potential for long-term therapy without immune suppression. However, scar tissue formation driven by the foreign body response (FBR) hinders nutritional exchange and ultimately leads to graft failure. We previously showed that inhibiting the colony-stimulating factor-1 receptor (CSF1R) pathway in monocytes and macrophages...

CONCLUSIONS: Our findings suggest sedation and analgesia practices with NMBA use in adult ICUs are generally guideline-concordant but require corroboration using more precise, quantitative medication data. Practice variation between hospitals is potentially concerning and warrants further investigation targeting adequacy of sedation and analgesia during NMBA use and assessing the clinical impact o...

Due to the damage happening in the nervous system, neuropathic pain occurs and it affects the quality of life of the patient to a great extent. Therefore, some clinical evaluations are required to assess the diagnostic outcomes precisely. A lot of information about the activities of the brain is provided by Electroencephalography (EEG) signals and neuropathic pain can be assessed and classified wi...

CONCLUSIONS: Greater SDoH difficulties and lower self-efficacy were associated with greater inability to practice COVID-19 personal protective behaviors. Interventions to meet SDoH-related challenges and increase self-efficacy could help encourage practice of personal protective behaviors and economically reduce disease burden during health crises.

Background: MYC dysregulation is frequent in ocular adnexal sebaceous carcinoma (SebCA), an aggressive malignancy without precision therapy. Fatty acid synthase (FASN) expression and lipid metabolism are commonly perturbed in high-MYC-expressing tumors; however, the role of MYC and FASN in the coregulation of lipid biosynthesis and tumorigenesis in SebCA is unknown. Methods: The aim of this study ...

Background/Objectives: Speech and motor control share overlapping neural mechanisms, yet their quantitative relationships in Parkinson's disease (PD) remain underexplored. This study investigated bidirectional associations between acoustic voice features and objective motor metrics to better understand how vocal and motor systems relate in PD. Methods: Cross-sectional baseline data from participan...

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