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Lab Members

Michael LeeMichael J. Lee, PhD

Associate Professor and Vice Chair, Department of Systems Biology

Office: AS5.1047
Phone: 774-455-3870

Bio: Mike is a native of Seattle and a proud UW Husky alum. He obtained his PhD in Pharmacology from UNC at Chapel Hill in 2008 working with Henrik Dohlman, and completed a postdoctoral fellowship at MIT, working with Michael Yaffe. Mike joined the faculty at UMass Chan in late 2013. He enjoys playing basketball, drinking great bourbon, and is an avid (but mediocre) skier. 

Scientific Interests: breast cancer therapy; combinatorial drug responses; signaling network dynamics; non-canonical cell death; the DNA Damage Response.

Associate Professor - Department of Systems Biology (link)
Associate Professor - Program in Molecular Medicine (link)
Affiliated Faculty - Department of Molecular, Cell and Cancer Biology (link)

Member - Center for Cancer Systems Biology (CCSB) at the Dana-Farber Cancer Institute
For more information about CCSB see: (

  • Gavin Birdsall

    Gavin Birdsall

    Graduate Student (GSBS, Bioinformatics Program)

    Gavin is from Southbury, CT. He attended the University of Connecticut, where he graduated with a degree in Physiology and Neurobiology, with a minor in Math. Prior to graduate school, he worked in the LoTurco Lab, where he studied tumor heterogeneity in a mouse model of supratentorial ependymoma, a rare glial tumor. He joined the lab in 2022 and is using functional genomic strategies to understand different ways in which dysregulated gene expression causes cell death. When he’s not in the lab, Gavin might be found gaming, playing the guitar or piano, tending to his many plants, or woodworking. In fact, he made most of his furniture himself!

  • Nick Harper

    Nick Harper

    Graduate Student (GSBS, IGP, NRSA/NCI F31 Fellow)

    Nick grew up in Wellesley, MA. He graduated from University of Vermont, where he studied Mathematics. After graduating, he worked in Kornelia Polyak’s lab at the Dana Farber Cancer Institute, where he gained valuable experience as a bioinformatician studying breast cancer. Nick joined the Lee Lab in 2020 and is exploring an unexpected mechanism of lethality for a common class of anti-cancer drugs. In his spare time, Nick enjoys mountain biking, skiing, and hiking with his dog Birdie.

  • Megan Honeywell

    Megan Honeywell, PhD

    Postdoctoral Fellow

    Megan is from Dunstable, MA, by way of Lubbock, TX. She studied Biochemistry at UNH, then following graduation worked for a year at Affinivax, helping to develop a vaccine for bacterial nosocomial infections. Her research interests are in the area of cancer biology and cancer therapy. Until December 2023, Megan was a graduate student in our lab, and during that time she developed MEDUSA, a new method for identifying death-regulatory genes in chemo-genetic profiling experiments. She is staying on for a few months as a postdoc - partially because no one can bear to see her leave - but also to create a generalized extension of MEDUSA. Megan is an artist at heart, and outside of the lab she might be found painting, sculpting, or finding other ways to explore her artistic side.

  • Sydney Porto

    Sydney Porto

    Undergraduate Intern (Goldwater Scholar)

    Sydney is from Bedford, NH. She is currently a senior at Harvey Mudd College, where she is a joint Chemistry and Biology major. She joined our lab in the summer of 2022, originally through our Summer Undergraduate Research Program, and now as an undergraduate intern. Her long-term goal is to pursue an MD/PhD. In the lab, her research interests are in understanding mechanisms of lethality following application of growth factor targeted therapies. Outside of the lab, she might be found hiking or trail running (especially with her dog!) and has been learning how to crochet.