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Lee Lab Publications

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        # Corresponding author(s)       * Co-first authors         (Lee Lab members in bold)    
27. Leylek O, Honeywell ME, Lee MJ#, Hemann MT#, Ozcan G#. (2024) Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy. Gastric Cancer Jul 20;
26. Flynn MJ, Harper NW, Li R, Zhu LJ, Lee MJ, Benanti JA#. (2024) Calcineurin promotes adaptation to chronic stress through two distinct mechanisms. bioRxiv [Pre-Print] Mar 19, 2024. Available from:
25. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ#. (2024) Functional genomic screens with death-rate analyses reveal mechanisms of drug action. Nature Chemical Biology Mar 13; 10.1038/s41589-024-01584-7.
            * see News and Views Article: The death gaze of MEDUSA
24. Dixon SJ# and Lee MJ#. (2023) Quick tips for interpreting cell death experiments. Nature Cell Biology Nov 20. 10.1038/s41556-023-01288-5
23. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Cruz-Gordillo P, Porto SA, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ#. (2023) p53 controls choice between apoptotic and non-apoptotic death following DNA damage. bioRxiv [Pre-Print] May 17, 2023. Available from: doi:
22. Leighow SM, Landry BD, Lee MJ, Peyton SR, Pritchard JR#. (2022) Agent-based models help interpret patterns of clinical drug resistance by contextualizing competition between distinct drug failure modes. Cellular and Molecular Engineering Nov 15; 10.1007/s12195-022-00748-6
21. Diot C, Garcia-Gonzalez AP, Vieira AF, Walker M, Honeywell ME, Doyle H, Ponomarova O, Rivera Y, Na H, Zhang H, Lee MJ, Olsen CP, Walhout AJM#. (2022) Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism. Nature Communications Sept 23; 13(1):5595
20. Pritchard J, Lee MJ, Peyton SR#. (2022) Materials-driven drug approaches to understand extrinsic resistance in cancer. Soft Matter Apr 13; DOI:10.1039./D2SM00071G
19. Jansen LE, Kim H, Hall CL, McCarthy TP, Lee MJ, Peyton SR#. (2022) A poly(ethylene glycol) three-dimensional bone marrow hydrogel. Biomaterials Jan 1; 280: 121270
18. Richards R#, Honeywell ME, Lee MJ#. (2021) FLICK: an optimized plate reader-based assay to infer cell death kinetics. STAR Protocols Mar 19; 2(1), 100327.
17. Cruz-Gordillo P*, Honeywell ME*, Harper NW, Leete T, Lee MJ#.(2020) ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells. Science Signaling Nov 17; 13(658), eabb9820.
16. Schwartz HR*, Richards R*, Fontana RE, Joyce AJ, Honeywell ME, Lee MJ#. (2020) Drug GRADE: an integrated analysis of population growth and cell death reveals drug-specific and cancer subtype-specific response profiles. Cell Reports Jun 23; 31(12): 107800
15. Richards R, Schwartz HR, Honeywell ME, Stewart MS, Cruz-Gordillo P, Joyce AJ, Landry BD, Lee MJ#.(2020) Drug Antagonism and Single Agent Dominance Result from Differences in Death Kinetics. Nature Chemical Biology DOI: 10.1038/s41589-020-0510-4                          
14. Matthew-Onabanjo AN, Janusis J, Mercado-Matos J, Carlisle AE, Kim D, Levine F, Cruz-Gordillo P, Richards R, Lee MJ, Shaw LM#. (2020) Beclin 1 promotes endosome recruitment of hepatocyte growth factor tyrosine kinase (HRS) to suppress tumor proliferation. Cancer Research Jan 15;80(2):249-262 PMCID: PMC6980665 
13. Heijink AM, Everts M, Honeywell ME, Richards R, Kok YP, de Vries EGE, Lee MJ#, van Vugt MATM# (2019) Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Cell Reports Aug 27;28(9):2345–5. 
12. Landry BD, Leete T, Richards RCruz-Gordillo P, Schwartz HR, Honeywell ME, Ren G, Schwartz AD, Peyton SR, Lee MJ# (2018) Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells. Molecular Systems Biology 14(8):e8322
11. Andrews BJ, Walhout AJ, Iyengar R, The Human Cells Project Working Group (2016) Quantitative Human Cell Encyclopedia. Science Signaling 9(443): mr1
10. Landry BD, Clarke DC, Lee MJ# (2015) Studying Cellular Signal Transduction with OMIC Technologies. Journal of Molecular Biology 427(21): 3416-3440
9. Lee MJ# (2015) Let a Hundred Flowers Bloom: The Role of Context Dependence in Creating Phenotypic Diversity Following Targeted Therapy. Molecular Cell 57: 763-764
8. Lee MJ and Yaffe MB#. (2014) Protein regulation in signal transduction. In: Cantley LC, Hunter T, Sever R, and Thorner J (eds), Signal Transduction: Principles, Pathways, and Processes 1st Ed. CSHL Press: 31-50
7. Morton SW*, Lee MJ*, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB#, & Hammond PT#. (2014) A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Science Signaling 7: ra44 
6. Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chenn CC, White FM, Bradner JE, Yaffe MB# (2013) The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 498: 246–250
5. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, Macbeath G, Yaffe MB# (2012) Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 149: 780–794
4. Tentner AR*, Lee MJ*, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB# (2012) Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Molecular Systems Biology 8: 568
3. Torres MP*, Lee MJ*, Ding F, Purbeck C, Kuhlman B, Dokholyan NV, Dohlman HG# (2009) G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase. Journal of Biological Chemistry 284: 8940–8950 
2. Lee MJ and Dohlman HG# (2008) Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Current Biology 18: 211–215
1. Wang Y, Marotti LA, Lee MJ, Dohlman HG# (2004) Differential regulation of G protein alpha subunit trafficking by mono- and poly-ubiquitination. Journal of Biological Chemistry 280: 284–291