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Metabolic Network (MetNET)

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What is Metabolism?

Metabolism refers to the various intracellular biochemical processes that produce or break down cellular building blocks, generate energy, and maintain reduction-oxidation balance. MetNet researchers are interested in identifying bioactive metabolites, the enzymes and transporters that produce them, and the signaling mechanisms that govern metabolic pathways. Using a variety of model organisms MetNet scientists are exploring metabolism in normal cellular and tissue-specific functions and in the pathogenesis of many human diseases and host-pathogen interactions.

Metabolic regulation is the orchestrated manner in which diet, activity, and genetics converge to control organism growth, nutrient balance, and disease susceptibility. MetNet researchers are exploring how adipose tissue, liver, skeletal muscle, pancreas, brain, and the immune system communicate to control metabolic homeostasis.  Of particular interest to the MetNet is how an imbalance or disruption of metabolism can result in obesity, diabetes, cardiovascular disease, infection and cancer.

Our goals are:

  1. To provide a conduit for interaction, open discussion and sharing of expertise in the various facets of metabolism and metabolic regulation.
  2. To foster collaborative projects in both basic and translational research.
  3. To develop a pipeline for accelerated translation of UMass research to therapeutics by partnering with Pfizer for our monthly seminar series
  4. To provide a resource for students and post-docs interested in academic or industry careers in metabolism research