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Developing Breakthrough RNA Therapeutics

By interweaving nucleic acid scientists with clinicians dedicated to finding new cures, our goal is to create a new paradigm for organizing molecular research that enables the rapid application of new biological discoveries to solutions for unmet challenges in human health.

RTI Spotlight

Andrei Korostelev, PhD, professor of RNA therapeutics, studies how bacteria can develop resistance to antibiotics, which has become a problem in treating infection. “Antibiotic resistance may cause the next global health crisis,” Dr. Korostelev said. Learn more about his work.

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2022 RNA Therapeutics: From Concept to Clinic

Save the dates for June 22-24, 2022 for the 4th annual RNA Therapeutics Symposium. Inclusivity and family support awards are available!

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ScienceLIVE Educational Outreach Program

ScienceLIVE is an educational science outreach program for Worcester area middle schools. We provide opportunities for students to engage with our diverse postdoctoral and graduate student trainees through interactive, exciting virtual and hands-on STEM activities.


Support Our Next Breakthrough

For decades, scientists at UMass Chan have been pioneers in RNA biology and leading innovators in the development of information-based therapeutics: cutting-edge therapeutic tools that leverage our understanding of the human genome in ways that are revolutionizing how we treat disease. With your support, we are poised to unleash their power, and change the world for the better.
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Research Spotlight


Preeclampsia (PE) affects up to 10% of human pregnancies worldwide and is a leading cause of maternal and fetal mortality and morbidity. Building off of the work of Melissa Moore's group, the Khvorova lab developed a framework for the chemical optimization of siRNAs for preeclampsia as well as other targets and clinical indications. This allows for more efficient placental delivery, silencing, as well as safety of sFLT1-targeting siRNAs. See more at Molecular Therapy Nucleic Acids on the Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.  


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Journey of a Nobel Discovery

Presented by ICBA, BBC StoryWorks

Meet Craig Mello, part of the RTI at UMass Chan, who was awarded the 2006 Nobel Prize in Physiology or Medicine, with Andrew Z. Fire, for the discovery of RNA interference. The discovery of RNAi has given scientists unprecedented opportunities to develop new life-saving therapies and advance our basic understanding of biology. 

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