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Developing Breakthrough RNA Therapeutics

By interweaving nucleic acid scientists with clinicians dedicated to finding new cures, our goal is to create a new paradigm for organizing molecular research that enables the rapid application of new biological discoveries to solutions for unmet challenges in human health.

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RTI Spotlight

Carolyn Kraus, a PhD candidate in the Morningside Graduate School of Biomedical Sciences Interdisciplinary Graduate Program, has received a Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study how CRISPR/Cas9 tools can be used to develop a therapeutic for Duchenne muscular dystrophy. Read more»


2024 RNA Therapeutics: From Concept to Clinic

Save the dates for our 6th annual RNA Therapeutics Symposium, June 26-28, 2024!

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ScienceLIVE Educational Outreach Program

ScienceLIVE is an educational science outreach program for Worcester area middle schools. We provide opportunities for students to engage with our diverse postdoctoral and graduate student trainees through interactive, exciting virtual and hands-on STEM activities.


Support Our Next Breakthrough

For decades, scientists at UMass Chan have been pioneers in RNA biology and leading innovators in the development of information-based therapeutics: cutting-edge therapeutic tools that leverage our understanding of the human genome in ways that are revolutionizing how we treat disease. With your support, we are poised to unleash their power, and change the world for the better.
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Research Spotlight


Dr. Wen Xue at the RNA Therapeutics Institute at University of Massachusetts Chan Medical School and Dr. Daniel Anderson at MIT have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA (mRNA) encoding useful proteins. mRNA holds great potential as a therapeutic for treating a variety of diseases caused by faulty genes. One obstacle to its deployment thus far has been difficulty in delivering it to the right part of the body, without off-target effects. Read more about Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing at Nature Biotechnology.

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Journey of a Nobel Discovery

Presented by ICBA, BBC StoryWorks

Meet Craig Mello, part of the RTI at UMass Chan, who was awarded the 2006 Nobel Prize in Physiology or Medicine, with Andrew Z. Fire, for the discovery of RNA interference. The discovery of RNAi has given scientists unprecedented opportunities to develop new life-saving therapies and advance our basic understanding of biology. 

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