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Developing Breakthrough RNA Therapeutics

By interweaving nucleic acid scientists with clinicians dedicated to finding new cures, our goal is to create a new paradigm for organizing molecular research that enables the rapid application of new biological discoveries to solutions for unmet challenges in human health.


RTI Spotlight

Anastasia Khvorova, PhD, professor of RNA therapeutics, was elected to the National Academy of Inventors Fellows Class of 2022! The new class is comprised of 169 prolific academic innovators from over 110 research universities and research institutes worldwide. Read more.

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2023 RNA Therapeutics: From Concept to Clinic

Save the dates for June 21-23, 2023 for the 5th annual RNA Therapeutics Symposium. Inclusivity and family support awards are available!

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ScienceLIVE Educational Outreach Program

ScienceLIVE is an educational science outreach program for Worcester area middle schools. We provide opportunities for students to engage with our diverse postdoctoral and graduate student trainees through interactive, exciting virtual and hands-on STEM activities.


Support Our Next Breakthrough

For decades, scientists at UMass Chan have been pioneers in RNA biology and leading innovators in the development of information-based therapeutics: cutting-edge therapeutic tools that leverage our understanding of the human genome in ways that are revolutionizing how we treat disease. With your support, we are poised to unleash their power, and change the world for the better.
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Research Spotlight


Work from the Sontheimer and Xue labs showcase a compact base editor that enables efficient in vivo delivery using a single adeno-associated virus (AAV) vector. The innovation, once approved in clinical trials, could lower the doses of AAV vector needed to achieve therapeutic efficacy and bolster precision medicine approaches using somatic genome editing by making them faster and safer. See more at GEN Biotechnology on the​​ ​​Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector​.


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Journey of a Nobel Discovery

Presented by ICBA, BBC StoryWorks

Meet Craig Mello, part of the RTI at UMass Chan, who was awarded the 2006 Nobel Prize in Physiology or Medicine, with Andrew Z. Fire, for the discovery of RNA interference. The discovery of RNAi has given scientists unprecedented opportunities to develop new life-saving therapies and advance our basic understanding of biology. 

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