Focus: C.elegans behavioral genetics

Focus: Understanding the molecular mechanisms of frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and Alzheimer disease (AD).

Focus:  Assessing how vertebrate hosts and their immune system interact with intestinal nematodes, to control autoimmune diseases including MS; and the cognitive impact of parasitic nematodes.

Higgins Family Professor of Neuroscience
Focus: Neurodegenerative diseases, especially Parkinson's and Huntington's diseases.
Lab Web-page

Focus: Neuronal Cell Fate Specification.      

Focus: Cell death and autophagy.

SCOPE Imaging Core Director

Focus: Light microscopy and spatial 'omics

Focus: Developing gene therapies for untreatable genetic diseases affecting the CNS  

Focus: Clinical Neuropsychiatry and neuropsychiatry training

Focus: Macrophages and the enteric nervous system in intestinal health and disease

Paul J. DiMare Chair in Neurodegenerative Disease   
Focus: Pathogenic mechanisms underlying Amyotrophic Lateral Sclerosis; protein misfolding in ALS
Lab Webpage

Focus: Activity-dependent gene expression in the primate brain

Focus: Genetic modeling of disease

Donna M. and Robert J. Manning Chair in Neuroscience
Focus: Identification of gene defects in neuromuscular diseases; Amyotrophic Lateral Sclerosis

Focus: Mechanisms of axon regeneration and degeneration in the aging nervous system

Focus: Cellular and molecular mechanisms underlying motor learning

Focus: Using induced pluripotent stem cells from patient samples to model Herpes viral infection as a cause of Alzheimer’s disease and hearing loss due to Cisplatin treatment.
Lab WebPage

Focus: Epilepsy

Barrett Family Term Chair in Neurodevelopmental Disorders
Focus: Neurodevelopmental disorders

Endowed Chair in Diabetes
Focus: Adipose tissue biology and metabolic diseases.

The Isadore and Fannie Foxman Chair of Medical Research
Focus: Investigating cellular and molecular interations among metabolic tissues, macrophages, neuronal signals and the vasculature that define both normal and metabolic disease states.

Focus: Developing gene therapies for rare neurological and neuromuscular diseases.

Investigator, Howard Hughes Medical Institute

H. Arthur Smith Chair in Cancer Research
Focus: Mechanisms by which growth factors regulate cellular proliferation and signaling.

Director, Department of Animal Medicine

Focus: Investigate neuromuscular diseases with an emphasis on congenital and other muscular dystrophies; cell death mechanisms and inflammatory pathway regulation.

Associate Director NeuroNexus Institute

Focus: Sensory perception in people with or at risk for mood and anxiety disorders.

PI, Wellstone Muscular Dystrophy Program at UMass Chan Medical School

Focus: Muscular Dystrophies
Lab website

Focus: Circadian Rhythms and photoreception in Drosophila.

Focus: Schizophrenia

Focus: Identification of drug targets and small molecules to treat Fragile X Syndrome and Friedreich's Ataxia

Focus: Activity-dependent synaptic plasticity; Neuronal circuit development and function in C. elegans.
Lab Webpage

Director, Eunice Kennedy Shriver Center

Robert M. and Shirley S. Siff Chair in Autism
Focus: Autism, early onset schizophrenia and bipolar disorder, neuroimaging, psychopharmacology.
The Child and Adolescent NeuroDevelopment Initiative (CANDI)

Focus: The roles of Inhibitory neurons in neuropsychiatric diseases.

Focus: Undergraduate and graduate neuroanatomy education.

The Governor Paul Cellucci Chair in Neuroscience Research
Focus: Understanding Frontotemporal Dementia (FTD) and ALS.
Lab Webpage

Director, Horae Gene Therapy Center

Penelope Booth Rockwell Chair in Biomedical Research
Focus: Adeno-associated virus vectors for gene therapy of genetic diseases including Canavan Disease

Focus: Immune system dysfunction including multiple sclerosis, with an emphasis on B lymphocyte contribution to pathology and biomarkers of disease progression.

Focus: Gene Therapy and Neurometabolism for Rare Neurological Diseases.

Focus: Neurogenetics; lysosomal storage disorders.

Director, New England Center for Stroke Research

Focus: Minimally invasive neuroendovascular surgery

Focus: Adeno-Associated Virus (AAV) gene therapy in animal models of Sandhoff and Tay-Sachs diseases

Focus: Non-GPCR Chemosensors for Mammalian Olfaction

Focus: Gene therapy in large animal models

Focus: Epigenetic Regulation and Nuclear Structure

Focus: Motor neuron degeneration in amyotrophic lateral sclerosis.

Focus: Multiple Sclerosis, Neuroimaging, Psychoneuroimmunology

Focus: Stroke and brain injury.

Focus: Immunometabolism in neurodegeneration

Focus: Multiple sclerosis and other autoimmune neurological diseases; and neurological complications of HIV infections.

Marcellette G. Williams Scholar

Focus: Neural-immune communication; Comparative immunology.
Lab website

Gerald L. Haidak, MD, and Zelda S. Haidak Professorship in Cell Biology (est. 1999)
Focus: Post-transcriptional control of gene expression in model systems and genetic disorders

Senior Consulting Vice Provost for Mentorship, Leadership, and Transformation

Maroun Semaan Chair in Neurosurgery
Focus: Normal-pressure hydrocephalus; gliomas

Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research
Focus: Comparative genomics and evolutionary biology in humans and dogs.

Focus: Gene Therapy, T-REGS and immune response to AAVs

Focus: Neuro-imaging and Neuroinformatics; functional MRI, morphometric analysis.

Remondi Family Chair in Biomedical Research
Focus: Therapeutic gene silencing in vivo.

Focus: Identifying alterations in metabolic pathways supporting cancer cells (gliomas) and exploiting these alterations for therapeutic purposes.
Lab website

Focus: Human brain development and maternal-infant bonding

Focus: Bioinformatic approaches in neurological diseases

Focus: Structure, Function and Modulation of Ion Channels.
Lab Webpage

Focus: Genetics of Familial and Sporadic ALS.

Leo P. and Thomas M. LaChance Chair in Medical Research
Focus: Chromosome silencing, Down Syndrome, and Alzheimer's Disease
Lab Web-page

Focus: Autoimmune Uveitis

Focus: To understand the genetic mechanisms of complex neurological diseases (ASD and Alzheimer’s) through computational and statistical methods and experimental technology.
Lab website

Focus: Developing translational gene therapy for mitochondrial disease with neurological manifestations, such as Leigh syndrome.

Focus: Addiction, neuropsychiatric diseases and circadian rhythms  
Lab Website: https://wickedneuro.com/

Focus: Translational regulation in models of Fragile X Syndrome.

Focus: The role of mitochondria and the endoplasmic reticulum in neurodegeneration and aging.
Lab website

Focus: Drugs of abuse and memory; electrophysiology.

Worcester Foundation for Biomedical Research Chair II
Focus: Mucosal inflammation, host:pathogen interactions, and cancer biology.

Focus: Cocaine and antidepressant-sensitive monoamine transporters.

Focus: Illuminating biological processes with chemistry.

Focus: Adult brain tumors, stereotactic radiosurgery, translational research.

Assistant Vice Provost for Health Equity

Focus: Regulation of vesicle targeting and fusion.

Focus: Primary cilia, hedgehog and Wnt signaling and extracellular matrix metalloproteinases

Director, Epilepsy Service

Focus: Epilepsy

Focus: Using small to macromolecular drug delivery to phagocytes to modulate inflammation and pathologies associated with infectious, autoimmune and neurodegenerative diseases.

Vitold Arnett Professorship in Cell Biology
Focus: RNA traffic in eukaryotic cells, RNA processing, RNA-protein interactions, microRNAs.

Focus: Chronic opioid use for the treatment of pain and prevention of side-effects and opioid addiction

Focus: Neurodegeneration in the retina; retinitis pigmentosa.
Lab Web-page

Director for Clinical Research, NeuroNexus Institute
Director, Division of Neurointerventional Surgery
Director, Neurointerventional Fellowship Program

Focus: Stroke treatment using mechanical thrombectomy, an endovascular procedure that is performed in neurointerventional radiology.

Focus: Scavenger receptors in inflammation and autoimmunology

Focus: Immunophenotype in Multiple Sclerosis, Neuropsychiatric Lupus and other conditions, neuroimmune interactions in the skin

Arthur F. Koskinas Chair in Neuroscience
Focus: Translational control in meiosis, mitosis, and neuronal synaptic plasticity, Fragile X syndrome.

Focus: Calcium Channels and Neuronal Plasticity.

Focus: Molecular genetic mechanisms of neuropsychiatric diseases and dementia.

UMass Memorial Chair in Radiology
Focus: Radiology

Irving S. and Betty Brudnick Chair in Psychiatry
Focus: Clinical Research in Affective Disorders and Sexual Dysfunction; Psychopharmacology.

Focus: Uncovering aberrant protein interactions in neurodegenerative diseases for biomarkers and therapeutic development.

Focus: Post-transcriptional regulation of maternal mRNA in development.
Lab Webpage

Focus: Structural and Functional Neuroimaging, Image Processing

UMass Chan Medical School Chair in Biomedical Research
Focus: Neuron-glia interactions regulating synaptic circuit development and plasticity.

Focus: Neuro-Immune Interactions; Neuropathogenesis of viral infection

Focus: Preclinical gene therapy of neurological diseases and brain cancer.

Focus: Parkinson’s disease, Movement disorders, biomarker development

Focus: Forensic neuropathology and CNS neoplasia.

Director, Brudnick Neuropsychiatric Research Institute
Focus: Neuronal nicotinic acetylcholine receptors in addiction and neurological disease.

Director, Small Molecule Screening Facility

Focus: Transposon regulation of neuromuscular junction plasticity

Focus: Uncovering mechanisms of neurodevelopmental disorders using zebrafish

Focus: Molecular and cellular functions of the OXR family of oxidation resistance genes in order to determine how they protect cells from oxidative stress induced DNA damage and cell death.

UMass Memorial Kaur Chair in Anesthesia and Perioperative Medicine  
Focus: Anesthesiology

Focus: AAV Gene Therapy for Genetic Diseases

Focus: Therapeutic gene silencing with chemically modified antisense oligonucleotides.

Executive Director, NeuroNexus Institute
Director, Graduate Program in Neuroscience

Focus: Molecular regulation and physiological impact of circadian rhythms.

Focus: Skin barrier immunity; Hidradenitis Suppurativa

Worcester Foundation for Biomedical Research Chair
Focus: Neural mechanisms of stress and addiction

Focus: Molecular and neural circuit mechanisms underlying behavior; light-evoked escape behavior.

Focus: Mechanism and therapy of neurodegenerative diseases including FTD and ALS.

Focus: Glioblastoma; Normal Pressure Hydrocephalus

Focus: Neural activity and behavioral changes during development
Lab website

Katz Family Chair in Psychiatry
Focus: Mood disorders and substance use disorders in perinatal populations

Focus: Cancer; Chromosomal silencing and Trisomy 21

Focus: Interplay of sensory systems and internal state; taste
Lab website

Focus: Smooth muscle in health and disease.

Focus: Pediatric Neurology; Autism

Focus: Protein Misfolding and Disease.