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Metallic Implant Surface Modifications

Strategies to reduce periprosthetic infections and enhance implant osteointegration

Read our publications:

Jordan D. Skelly, Feiyang Chen, Shing-Yun Chang, Rewati R. Ujjwal, Ananta Ghimire, David C. Ayers and Jie Song. Tuning On-demand Releases of Vancomycin Covalently Tethered to Implant Coatings through the Chemical Modification of a Micrococcal-Nuclease-Sensitive Oligonucleotide Linker. ACS Appl Mater Interfaces 2023, 10.1021/acsami.3c05881. View Publication

Ananta Ghimire and Jie Song. Anti-periprosthetic infection strategies: from implant surface topographical engineering to smart drug-releasing coatings. ACS Appl Mater Interfaces. 2021, 13(18):20921–20937. View Publication.

Ben Zhang, Jordan D. Skelly, Benjamin Braun, David C. Ayers and Jie Song. Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing Staphylococcus aureus periprosthetic infections ACS Appl Bio Mater 2020, 3(9), 5896-5904. View Publication

Ananta Ghimire, Jordan D. Skelly and Jie Song. Micrococcal-nuclease-triggered on-demand release of vancomycin from Intramedullary implant coating eradicates Staphylococcus aureus infection in mouse femoral canals. ACS Central Science 2019, Dec 10; 5(12): 1929–1936. View Publication

Zhang B, Braun B, Skelly J, Ayers D, Song J. Significant Suppression of S. aureus Colonization on Intramedullary Ti6Al4V Implants Surface-grafted with Vancomycin-bearing Polymer Brushes. ACS Appl Mater Interfaces. 2019 Jul 17; 11(32):28641-28647. PMID: 31313901. View in: PubMed
Liu P, Song J. Well-controlled ATRP of 2-(2-(2-Azidoethyoxy)ethoxy)ethyl Methacrylate for High-density Click Functionalization of Polymers and Metallic Substrates. J Polym Sci A Polym Chem. 2016 May 01; 54(9):1268-1277. PMID: 27616816. View in: PubMed
Liu P, Domingue E, Ayers DC, Song J. Modification of Ti6Al4V substrates with well-defined zwitterionic polysulfobetaine brushes for improved surface mineralization. ACS Appl Mater Interfaces. 2014 May 28; 6(10):7141-52. PMID: 24828749. View in: PubMed
Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95. PMID: 21651998. View in: PubMed