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Functional Hydrogels

1. ClickGels with precisely tuned degradation and viscoelasticity

Yu Tan and Jie Song. Independent and Synergistic Modulations of Viscoelasticity and Stiffness of Dynamically Crosslinked Cell-encapsulating ClickGels by Covalently Tethered Polymer Brushes. Biomacromolecules, 2021, 22(8), 3408-3415. View Publication
Yu Tan, Henry Huang, David C. Ayers and Jie Song. Modulating viscoelasticity, stiffness and degradation of synthetic cellular niches via stoichiometric tuning of covalent versus dynamic non-covalent crosslinking. ACS Central Science. 2018; 4:971-981.
Xu J, Feng E, Song J. Bioorthogonally cross-linked hydrogel network with precisely controlled disintegration time over a broad range. J Am Chem Soc. 2014 Mar 19; 136(11):4105-8. PMID: 24597638.
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Xu J, Filion TM, Prifti F, Song J. Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry. Chem Asian J. 2011 Oct 4; 6(10):2730-7. PMID: 21954076.
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2. Photogels for cell encapsulation, biomineralization and therapeutics deliveries

Henry Huang, Yu Tan, David C. Ayers and Jie Song. Anionic and zwitterionic residues modulate stiffness of photo-crosslinked hydrogels and cellular behavior of encapsulated chondrocytes. ACS Biomater Sci Eng. 2018; 4:1843-1851.
Liu P, Emmons E, Song J. A comparative study of zwitterionic ligands-mediated mineralization and the potential of mineralized zwitterionic matrices for bone tissue engineering. J Mater Chem B Mater Biol Med. 2014 Nov 21; 2(43):7524-7533. PMID: 25558374.
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Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin Orthop Relat Res. 2014 Dec; 472(12):4015-23. PMID: 25099263.
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Liu P, Skelly JD, Song J. Three-dimensionally presented anti-fouling zwitterionic motifs sequester and enable high-efficiency delivery of therapeutic proteins. Acta Biomater. 2014 Oct; 10(10):4296-303. PMID: 24956565.
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Li X, Xu J, Filion TM, Ayers DC, Song J. pHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute. Clin Orthop Relat Res. 2013 Aug; 471(8):2540-7. PMID: 23070662.
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Liu P, Song J. Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization. Biomaterials. 2013 Mar; 34(10):2442-54. PMID: 23332320.
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Tera M. Filion and Jie Song. Scalable functional bone substitutes: strategic integration of key structural elements of bone in synthetic biomaterials, Chapter 12. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 233-248.
Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11. PMID: 20818999.
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Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11. PMID: 19350632.
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Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107. PMID: 18546185.
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