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Publications

  1. Jordan D. Skelly, Feiyang Chen, Shing-Yun Chang, Rewati R. Ujjwal, Ananta Ghimire, David C. Ayers and Jie Song. Tuning On-demand Releases of Vancomycin Covalently Tethered to Implant Coatings through the Chemical Modification of a Micrococcal-Nuclease-Sensitive Oligonucleotide Linker. ACS Appl Mater Interfaces 2023, 10.1021/acsami.3c05881. View Publication
  2. Xiaowen Xu, Jordan Skelly and Jie Song. Chemically crosslinked amphiphilic degradable shape memory polymer nanocomposites with readily tuned physical, mechanical, and biological properties. ACS Appl Mater Interfaces 2023, 15(2), 2693-2704. View Publication
  3. Chloe Herczeg and Jie Song. Sterilization of Polymeric Implants: Challenges and Opportunities. ACS Appl Bio Mater 2022, doi 10.1021/acsabm.2c00793. View Publication
  4. Xiaowen Xu and Jie Song. “Bone Grafting in the Regenerative Reconstruction of Critical-Size Long Bone Segmental Defects” in Bone Tissue Engineering: Bench to Bedside Using 3D Printing, Fernando P.S. Guastaldi and Bhushan Mahadik Ed., Springer Nature Switzerland, ISBN 978-3-030-92013-5, ISBN 978-3-030-92014-2 (eBook), 2022, pp 165-192, doi 10.1007/978-3-030-92014-2_8. View Publication
  5. Yu Tan and Jie Song. Independent and Synergistic Modulations of Viscoelasticity and Stiffness of Dynamically Crosslinked Cell-encapsulating ClickGels by Covalently Tethered Polymer Brushes. Biomacromolecules, 2021, 22(8), 3408-3415. View Publication
  6. Xiaowen Xu#, Jing Zhang#, Tera Filion, Ali Akalin and Jie Song (#equal contribution). Modulating mechanical and shape-memory properties while mitigating degradation-induced inflammation of polylactides by pendant aspirin incorporation. ACS Appl Mater Interfaces. 2021, 13(19), 22271-22281. View Publication
  7. Ananta Ghimire and Jie Song. Anti-periprosthetic infection strategies: from implant surface topographical engineering to smart drug-releasing coatings. ACS Appl Mater Interfaces. 2021 13(18):20921–20937. View Publication
  8. Xiaowen Xu and Jie Song. Segmental long bone regeneration guided by degradable synthetic polymeric scaffolds. Biomaterials Translational. 2020, 1(1), 33-45. View Publication
  9. Ben Zhang, Jordan D. Skelly, Benjamin Braun, David C. Ayers and Jie Song. Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing Staphylococcus aureus periprosthetic infections ACS Appl Bio Mater 2020, 3(9), 5896-5904. View Publication
  10. Ananta Ghimire, Jordan D. Skelly and Jie Song. Micrococcal-nuclease-triggered on-demand release of vancomycin from Intramedullary implant coating eradicates Staphylococcus aureus infection in mouse femoral canals. ACS Central Science 2019, Dec 10; 5(12):1929–1936. View Publication
  11. Ben Zhang, Jordan D. Skelly, Jacob Maalouf, David C. Ayers and Jie Song. Multi-functional scaffolds for facile implantation, spontaneous fixation and accelerated long bone regeneration in rodents. Science Translational Medicine. 2019; 11(502):eaau7411.
    View Publication
  12. Zhang B, Braun B, Skelly J, Ayers D, Song J. Significant Suppression of S. aureus Colonization on Intramedullary Ti6Al4V Implants Surface-grafted with Vancomycin-bearing Polymer Brushes. ACS Appl Mater Interfaces. 2019 Jul 17; 11(32):28641-28647.
    View in: PubMed
  13. Yu Tan, Henry Huang, David C. Ayers and Jie Song. Modulating viscoelasticity, stiffness and degradation of synthetic cellular niches via stoichiometric tuning of covalent versus dynamic non-covalent crosslinking. ACS Central Science. 2018; 4:971-981.
    View Publication
  14. Henry Huang, Yu Tan, David C. Ayers and Jie Song. Anionic and zwitterionic residues modulate stiffness of photo-crosslinked hydrogels and cellular behavior of encapsulated chondrocytes. ACS Biomater Sci Eng. 2018; 4:1843-1851.
    View Publication
  15. Ben Zhang and Jie Song. 3D Printed Biomaterials for Guided Tissue Regeneration. Small Methods. 2018; DOI: 10.1002/smtd.201700306.
    View Publication
  16. Filion TM, Skelly JD, Huang H, Greiner DL, Ayers DC, Song J. Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue. Stem Cell Res Ther. 2017 Mar 11; 8(1):65. PMID: 28283030.
    View in: PubMed 
  17. Huang H, Skelly JD, Ayers DC, Song J. Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus. Sci Rep. 2017 Feb 09; 7:42294. PMID: 28181577.
    View in: PubMed
  18. Zhang B, DeBartolo JE, Song J. Shape Recovery with Concomitant Mechanical Strengthening of Amphiphilic Shape Memory Polymers in Warm Water. ACS Appl Mater Interfaces. 2017 Feb 08; 9(5):4450-4456. PMID: 28125208.
    View in: PubMed
  19. Ben Zhang, Tera M. Filion, Artem B. Kutikov and Jie Song. Facile Stem Cell Delivery to Bone Grafts Enabled by Smart Shape Recovery and Stiffening of Degradable Synthetic Periosteal Membranes. Adv. Funct. Mater. 2017; 1604784.
    View Publication
  20. Huang H, Veien ES, Zhang H, Ayers DC, Song J. Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes. PLoS One. 2016; 11(1):e0148088. PMID: 26815610.
    View in: PubMed
  21. Liu P, Song J. Well-controlled ATRP of 2-(2-(2-Azidoethyoxy)ethoxy)ethyl Methacrylate for High-density Click Functionalization of Polymers and Metallic Substrates. J Polym Sci A Polym Chem. 2016 May 01; 54(9):1268-1277. PMID: 27616816.
    View in: PubMed
  22. Youssefian S, Liu P, Askarinejad S, Shalchy F, Song J, Rahbar N. Experimental and numerical measurements of adhesion energies between PHEMA and PGLYMA with hydroxyapatite crystal. Bioinspir Biomim. 2015 Aug; 10(4):046011. PMID: 26179911.
    View in: PubMed 
  23. Kutikov AB, Song J. Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications. ACS Biomater Sci Eng. 2015 Jul 13; 1(7):463-480. PMID: 27175443.
    View in: PubMed 
  24. Jianwen Xu and Jie Song. Shape Memory Polymers for Biomedical Applications (A volume in Woodhead Publishing Series in Biomaterials), L’Hocine Yahia Ed. Chapter 10: Polylactic acid (PLA)-based shape-memory materials for biomedical applications. 2015. View Publication.
  25. Kutikov AB, Skelly JD, Ayers DC, Song J. Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds. ACS Appl Mater Interfaces. 2015 Mar 4; 7(8):4890-901. PMID: 25695310.
    View in: PubMed 
  26. Liu P, Emmons E, Song J. A comparative study of zwitterionic ligands-mediated mineralization and the potential of mineralized zwitterionic matrices for bone tissue engineering. J Mater Chem B Mater Biol Med. 2014 Nov 21; 2(43):7524-7533. PMID: 25558374.
    View in: PubMed
  27. Kutikov AB, Reyer KA, Song J. Shape Memory Performance of Thermoplastic Amphiphilic Triblock Copolymer poly(D,L-lactic acid-co-ethylene glycol-co-D,L-lactic acid) (PELA)/Hydroxyapatite Composites. Macromol Chem Phys. 2014 Dec; 215(24):2482-2490. PMID: 26457046.
    View in: PubMed 
  28. Kutikov AB, Gurijala A, Song J. Rapid prototyping amphiphilic polymer/hydroxyapatite composite scaffolds with hydration-induced self-fixation behavior. Tissue Eng Part C Methods. 2015 Mar; 21(3):229-41. PMID: 25025950.
    View in: PubMed 
  29. Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin Orthop Relat Res. 2014 Dec; 472(12):4015-23. PMID: 25099263.
    View in: PubMed 
  30. Liu P, Skelly JD, Song J. Three-dimensionally presented anti-fouling zwitterionic motifs sequester and enable high-efficiency delivery of therapeutic proteins. Acta Biomater. 2014 Oct; 10(10):4296-303. PMID: 24956565.
    View in: PubMed 
  31. Liu P, Domingue E, Ayers DC, Song J. Modification of Ti6Al4V substrates with well-defined zwitterionic polysulfobetaine brushes for improved surface mineralization. ACS Appl Mater Interfaces. 2014 May 28; 6(10):7141-52. PMID: 24828749.
    View in: PubMed
  32. Zhang J, Song J. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. Acta Biomater. 2014 Jul; 10(7):3079-90. PMID: 24631657.
    View in: PubMed
  33. Xu J, Feng E, Song J. Renaissance of Aliphatic Polycarbonates: New Techniques and Biomedical Applications. J Appl Polym Sci. 2014 Mar 5; 131(5). PMID: 24994939.
    View in: PubMed 
  34. Xu J, Feng E, Song J. Bioorthogonally cross-linked hydrogel network with precisely controlled disintegration time over a broad range. J Am Chem Soc. 2014 Mar 19; 136(11):4105-8. PMID: 24597638.
    View in: PubMed 
  35. Filion TM, Song J. A sulfated nanofibrous mesh supporting the osteogenic differentiation of periosteum-derived cells. J Biomater Tissue Eng. 2013 Aug 1; 3(4):486-493. PMID: 25309819.
    View in: PubMed
  36. Li X, Xu J, Filion TM, Ayers DC, Song J. pHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute. Clin Orthop Relat Res. 2013 Aug; 471(8):2540-7. PMID: 23070662.
    View in: PubMed 
  37. Kutikov AB, Song J. An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells. Acta Biomater. 2013 Sep; 9(9):8354-64. PMID: 23791675.
    View in: PubMed 
  38. Zhao L, Kutikov A, Shen J, Duan C, Song J, Han G. Stem cell labeling using polyethylenimine conjugated (a-NaYbF4:Tm3+)/CaF2 upconversion nanoparticles. Theranostics. 2013; 3(4):249-57. PMID: 23606911.
    View in: PubMed
  39. Liu P, Song J. Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization. Biomaterials. 2013 Mar; 34(10):2442-54. PMID: 23332320.
    View in: PubMed 
  40. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano. 2012 Sep 25; 6(9):8280-7. PMID: 22928629.
    View in: PubMed 
  41. Jianwen Xu and Jie Song. Engineering Polylactic Acid with Thermal-responsive Shape Memory Effect for Medical Applications, Chapter 11. Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed.Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed. 2012.
  42. Xu J, Filion TM, Prifti F, Song J. Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry. Chem Asian J. 2011 Oct 4; 6(10):2730-7. PMID: 21954076. View in: PubMed
  43. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95. PMID: 21651998. View in: PubMed
  44. Xu J, Prifti F, Song J. A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates). Macromolecules. 2011 Apr 26; 44(8):2660-2667. PMID: 21686053. View in: PubMed 
  45. Filion TM, Kutikov A, Song J. Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds. Bioorg Med Chem Lett. 2011 Sep 1; 21(17):5067-70. PMID: 21536439. View in: PubMed 
  46. Chung WJ, Kwon KY, Song J, Lee SW. Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals. Langmuir. 2011 Jun 21; 27(12):7620-8. PMID: 21291244. View in: PubMed
  47. Jianwen Xu and Jie Song. Thermal responsive shape memory polymers for biomedical applications, Chapter 6. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 125-142. View Publication
  48. Tera M. Filion and Jie Song. Scalable functional bone substitutes: strategic integration of key structural elements of bone in synthetic biomaterials, Chapter 12. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 233-248. View Publication
  49. Filion TM, Xu J, Prasad ML, Song J. In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites. Biomaterials. 2011 Feb; 32(4):985-91. PMID: 21040968. View in: PubMed
  50. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11. PMID: 20818999. View in: PubMed 
  51. Xu J, Song J. High performance shape memory polymer networks based on rigid nanoparticle cores. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7652-7. PMID: 20375285. View in: PubMed 
  52. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11. PMID: 19350632. View in: PubMed 
  53. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107. PMID: 18546185. View in: PubMed 
  54. Su J, Iomdina E, Tarutta E, Ward B, Song J, Wildsoet CF. Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera. Exp Eye Res. 2009 Mar; 88(3):445-57. PMID: 19109950. View in: PubMed
  55. Song J. A chemical and engineering approach towards "smart" synthetic bone grafts. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):325. PMID: 18094494. View in: PubMed
  56. Kaufman JD, Song J, Klapperich CM. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res A. 2007 Jun 1; 81(3):611-23. PMID: 17187400. View in: PubMed 
  57. Song J, Malathong V, Bertozzi CR. Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone. J Am Chem Soc. 2005 Mar 16; 127(10):3366-72. PMID: 15755154. View in: PubMed 
  58. Jie Song and Carolyn R. Bertozzi. Functional polymers for bone tissue engineering applications. Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, H. S. Nalwa Ed. 2005; 2:371-392.
  59. Antoni P. Tomsia, Eduardo Saiz, Jie Song and Carolyn Bertozzi. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005; 7(11):999-1004. View Publication
  60. Jie Song and , Carolyn R. Bertozzi. Functional Hydrogel-Biomineral Composites Inspired by Natural Bone, Chapter 7. Polymer Biocatalysis and Biomaterials. 2005; 900:96-106. View Publication
  61. Song J, Cisar JS, Bertozzi CR. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J Am Chem Soc. 2004 Jul 14; 126(27):8459-65. PMID: 15238003. View in: PubMed 
  62. Cheng Q, Zhu S, Song J, Zhang N. Functional lipid microstructures immobilized on a gold electrode for voltammetric biosensing of cholera toxin. Analyst. 2004 Apr; 129(4):309-14. PMID: 15042161. View in: PubMed
  63. Jie Song, Raymond C. Stevens and Quan Cheng. Functional Amphiphilic and Bolaamphiphilic Poly(diacetylene) Assemblies with Controlled Optical and Morphological Properties, Chapter 7. Chromogenic Phenomena in Polymers. 2004; 888:96-109. View Publication
  64. Jie Song, Julia Chen, Catherine M. Klapperich, Vincent Eng and Carolyn R. Bertozzi. Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands. J. Mater. Chem. 2004; 14:2643-2648. View Publication
  65. Song J, Saiz E, Bertozzi CR. A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc. 2003 Feb 5; 125(5):1236-43. PMID: 12553825. View in: PubMed 
  66. Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. Preparation of pHEMA-CP composites with high interfacial adhesion via template-driven mineralization. J. Eur. Ceram. Soc. 2003; 23(15):2905-2919. View Publication
  67. Jie Song, Quan Cheng and Raymond C. Stevens. Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping. Chem. Phys. Lipids. 2002; 114:203-214. View Publication
  68. Jie Song, Quan Cheng, Shimin Zhu and Raymond C. Stevens. “Smart” Materials for Biosensing Devices: Cell-Mimicking Supramolecular Assemblies and Colorimetric Detection of Pathogenic Agents. Biomedical Microdevices. 2002; 4(3):213-221. View Publication
  69. Song J, Cheng Q, Kopta S, Stevens RC. Modulating artificial membrane morphology: pH-induced chromatic transition and nanostructural transformation of a bolaamphiphilic conjugated polymer from blue helical ribbons to red nanofibers. J Am Chem Soc. 2001 Apr 11; 123(14):3205-13. PMID: 11457054. View in: PubMed
  70. Jie Song and Rawle I. Hollingsworth. Homochiral 4-Hydroxy-5-hexenoic Acids and Their Derivatives and Homologues from Carbohydrates. Tetrahedron: Asymmetry. 2001; 12:387-391. View Publication
  71. Jie Song and Rawle I. Hollingsworth. Synthesis, Conformational Analysis and Phase Characterization of a Versatile Self-assembling Monoglucosyl Diacylglycerol Analog. J. Am. Chem. Soc. 1999; 121:1851-1861. View Publication