Our Research Focus: Innate immune recognition and signal transduction in flies and mammals

• How bacteria, viruses and parasites are recognized by innate immune receptors
• Molecular and biochemical mechanisms used by both the host and microbe to respond to infection
• The role of peptidoglycan sensing in inflammatory responses and diseases

Latest News from our Lab

Representative Publications

• Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 Aug 16;40(7):111225.
  
  
• Okuda K, Silva Costa Franco M, Yasunaga A, Gazzinelli R, Rabinovitch M, Cherry S, Silverman N. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. iScience, Volume 25, Issue 9,
  2022,104909. 

• ​Paik D, Monahan A, Caffrey DR, Elling R, Goldman WE, Silverman N. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. J Immunol. 2017 Jul 1;199(1):263-270.
  
  

More Publications

Join our Lab

We are currently recruiting for a post-doctoral position in our lab. Please contact Dr. Silverman directly if you are interested.