Welcome to the Silverman Lab
Our group is focused on illuminating the regulation of the innate immune and inflammatory responses in both insects and mammals. We are interested in how microbes are recognized by germline-encoded receptors and the molecular mechanisms involved in subsequent signal transduction pathways. In addition, we also examine how various environmental cues modulate innate immune responses. We rely heavily on the classic genetic model system of Drosophila melanogaster, the fruit fly, but also translate discoveries made in this model to more medically relevant systems, including vector mosquitoes and mammals. Long-term, we aim to understand the molecular mechanisms that underly the innate immune response in the context of both health and pathophysiology.
The Silverman lab is part of the Division of Infectious Diseases and Immunology and is also a member of the Program In Innate Immunity (PII), an interdisciplinary and interdepartmental group of investigators who are focused on discovering the underlying mechanisms that drive immune defenses and inflammation, in both health and disease.