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Data Collection

  • Cryo-EM imaging at low-dose condition and liquid nitrogen temperature
  • High image quality, high throughput
  • Automated cryo-ET data collection
  • Automated single particle data collection
  • Options for staff assist operation and remote control

Sample Preparation

  • Prepare cryo-EM grids

Cryo Grid Screening

  • Screen cryo grid conditions on auto-loader scope
  • Screening will provide low mag atlas, medium mag montages for a few good meshes, and a few images from good ice areas

Nano-particle Morphology Studies

·        Full morphology analysis for samples such as Lipid-based Nano-Particles (LNP) and AAV like particles.

·        Three different magnifications, ~50+ images in total.

·        Option for statistics analysis for size distribution and particle shapes.

Image Processing

  • Preliminary data processing for aligning movie frames in fly during data collection
  • 3D reconstruction for tomography data
  • 3D reconstruction of single particle data

Structure Determination

·        We now have bandwidth to take full projects. You send sample, we provide final structure.


  • Basic theory of electron microscopy
  • Hands-on training of basic TEM operation using existing EM Core Facility
  • Advanced training on TEM operation using SerialEM
  • Hands-on training for operating Titan Krios and Talos-Arctica
  • Negative stain sample preparation
  • Cryo-EM sample preparation

For information on Training, please see Core Director.