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  • UMass Chan researchers earn PolyBio Foundation award for long COVID, neurodegenerative disease study

    UMass Chan researchers earn PolyBio Foundation award for long COVID, neurodegenerative disease study

    The scientists will use a human cerebral organoid platform to evaluate the role of COVID in neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and dementia 

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  • Prestigious Kirschstein Award helps fund MD/PhD student's ALS research

    Prestigious Kirschstein Award helps fund MD/PhD student's ALS research

    MD/PhD student Abigail Hiller has received an award from the National Institute of Neurological Disorders and Stroke to study the role genes linked to Alzheimers disease play in ALS.

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  • UMass Chan leads multisite VA study on prism adaptation therapy for spatial neglect following stroke

    UMass Chan leads multisite VA study on prism adaptation therapy for spatial neglect following stroke

    A multisite Veterans Affairs study led by A.M. Barrett, MD, and Kevin Houston, OD, aims to define and validate brain imaging biomarkers that predict response to prism adaptation therapy in patients with spatial neglect following right-brain stroke.

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  • Nils Henninger study explores link between traumatic brain injury and onset of ALS/FTD

    Nils Henninger study explores link between traumatic brain injury and onset of ALS/FTD

    New study led by Nils Henninger, MD, PhD'18, suggests interplay between genetic factors and traumatic brain injury in behavioral and neurological deficits related to ALS and FTD in mice.

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  • Science for Living: Neurology chair and VA neurology chief, A.M. Barrett, highlights veterans’ link to ALS

    Science for Living: Neurology chair and VA neurology chief, A.M. Barrett, highlights veterans’ link to ALS

    Military veterans face a higher risk of ALS than the civilian population, according to years of studies. UMass Chan researchers are pursuing therapies to address the biological basis for this fatal neurodegenerative disease and work with clinical partners to provide expert rehabilitation for veterans.

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  • Angel Fund for ALS Research donates $711,000 for ALS research at UMass Chan

    Angel Fund for ALS Research donates $711,000 for ALS research at UMass Chan

    The Angel Fund for ALS Research has announced a $711,000 donation to support the research of Robert H. Brown Jr., DPhil, MD, at UMass Chan Medical School.

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  • Boston Marathon fitting tribute for families touched by ALS

    Boston Marathon a fitting tribute for families touched by ALS

    Sisters Ashley Craig and Lacey Foley joined the UMass ALS Cellucci Fund Boston Marathon team in memory of their grandmother. Brothers Dean and Zack Kennedy, PhD’19, are running on the Jake Kennedy ALS Fund team, in honor of their father.

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  • How frontotemporal dementia changes the brain

    How frontotemporal dementia changes the brain

    In a piece written for The Conversation, Fen-Biao Gao, PhD, talks about how frontotemporal dementia changes the brain and the research that is untangling its genetic causes.

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  • Ana Rita Batista, PhD, (left) instructor in neurology, pictured with Miguel Sena-Esteves, PhD, associate professor of neurology and director of the Translational Institute for Molecular Therapeutics..

    UMass Chan researchers achieve gene therapy milestone for potential Cockayne syndrome treatment

    Researchers working with UMass Chan Medical School’s Translational Institute for Molecular Therapeutics announced progress in developing a vector to deliver gene replacement therapy in mice models with Cockayne syndrome, a rare and fatal neurodegenerative disease that largely affects children and young adults.

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  • Top story: Motor neuron toxin associated with ALS identified by UMass Chan investigators

    Top story: Motor neuron toxin associated with ALS identified by UMass Chan investigators

    Top story: An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with ALS and frontotemporal dementia contributes to the motor neuron death that is the signature of these diseases.

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  • Top story: UMass Chan launches Translational Institute for Molecular Therapeutics

    Top Story: UMass Chan launches Translational Institute for Molecular Therapeutics

    Top story: The Translational Institute for Molecular Therapeutics leverages UMass Chan Medical School’s extensive experience in researching and developing gene therapies for early-stage clinical trials. Miguel Sena-Esteves, PhD, is director of the new institute.

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  • Sen. Markey praises UMass Chan-VA Central Western Massachusetts Healthcare System partnership

    Sen. Markey praises UMass Chan-VA Central Western Massachusetts Healthcare System partnership

    U.S. Sen. Edward Markey toured the Veterans Affairs community-based outpatient clinic on the campus of UMass Chan Medical School in Worcester on Tuesday.

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  • Susanne Muehlschlegel leads study on first-of-its-kind neuro ICU decision aids

    Susanne Muehlschlegel leads study on first-of-its-kind neuro ICU decision aids

    A pilot clinical trial led by UMass Chan Medical School and Yale School of Medicine may have unlocked an important tool for families to review all treatment options for patients in the neuroscience intensive care unit incapable of making their own decisions.

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  • Chancellor Collins: Momentum high at UMass Chan after year of milestone accomplishments

    Chancellor Collins: Momentum high at UMass Chan after year of milestone accomplishments

    In his annual Convocation address to the UMass Chan Medical School community on Thursday, Sept. 16, Chancellor Michael F. Collins expressed optimism for the Medical School’s ambitious future and touted the enormous momentum moving the school forward.

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  • Morningside Graduate School of Biomedical Sciences recognizes 41 new PhD candidates

    Morningside Graduate School of Biomedical Sciences recognizes 41 new PhD candidates

    The Morningside Graduate School of Biomedical Sciences honored the new doctoral candidates during its annual Qualifying Exam Recognition Ceremony on Wednesday, Sept. 14, at which Dean Mary Ellen Lane encouraged the honorees to continue “growing, learning and stretching out of your comfort zone.”

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  • Four seed grants will be supported by the Dan and Diane Riccio Fund for Neuroscience in 2022

    Four seed grants will be supported by the Dan and Diane Riccio Fund for Neuroscience in 2022

    The 2022 Dan and Diane Riccio Fund for Neuroscience seed grants will support four teams of researchers collaborating on multidisciplinary projects.

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  • A.M. Barrett named chair of Department of Neurology at UMass Chan

    Anna A.M. Barrett named chair of Department of Neurology at UMass Chan

    Physician-scientist A.M. Barrett, MD, is joining UMass Chan Medical School as chair and professor of neurology. Additionally, Dr. Barrett has been named chief of the Neurology Service at the VA Central Western Massachusetts Healthcare System.

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  • Inaugural Donna M. and Robert J. Manning Chairs celebrated at special investiture ceremony

    Inaugural Donna M. and Robert J. Manning Chairs celebrated at special investiture ceremony

    UMass Chan Medical School celebrated in a special investiture ceremony on June 22 the $5 million gift of UMass Lowell alumni Donna and Robert Manning, which established Donna M. and Robert J. Manning Chairs in neurosciences, orthopedics, obstetrics and gynecology, nursing, and biomedical sciences.

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  • Eric Baehrecke, Jeanne Lawrence and Alan Mullen appointed to endowed chairs

    Eric Baehrecke, Jeanne Lawrence and Alan Mullen appointed to endowed chairs

    Chancellor Michael F. Collins announced that the University’s Board of Trustees has approved the appointment of three of faculty members to endowed chairs. They join more than 60 named chairs at UMass Chan.

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  • Donna and Robert Manning donate $5 million to UMass Chan to establish endowed chairs

    Donna and Robert Manning donate $5 million to UMass Chan to establish endowed chairs

    Five new endowed chairs have been established at UMass Chan Medical School, thanks to the generosity of Donna and Robert Manning, proud alumni and preeminent pillars of the University of Massachusetts.

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  • Boston Marathon runners raise thousands for UMass Chan ALS research

    Boston Marathon runners raise thousands for UMass Chan ALS research

    ALS research at UMass Chan Medical School is the big beneficiary as select Boston Marathon runners raise tens of thousands of dollars each year. This year, five competitors in the April 18 event are running as part of the UMass Chan ALS Cellucci Fund Boston Marathon team and two sons of the late Jake Kennedy will run in support of the Jake Kennedy ALS Fund.

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  • Muscle stem cell technology developed at UMass Chan prelude to new muscular dystrophy therapeutics

    Muscle stem cell technology developed at UMass Chan prelude to new muscular dystrophy therapeutics

    Charles P Emerson Jr., PhD, and colleagues at UMass Chan Medical School have developed a technology to isolate human skeletal muscle stem cells, or progenitor cells, from induced pluripotent stem cells.

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  • Motor neuron toxin associated with ALS identified by UMass Chan investigators

    Motor neuron toxin associated with ALS identified by UMass Chan investigators

    An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with ALS and frontotemporal dementia contributes to the motor neuron death that is the signature of these diseases.

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  • Ananya Kumar of Hopkinton wins Central Massachusetts Brain Bee

    Ananya Kumar of Hopkinton wins Central Massachusetts Brain Bee

    Hosted by the Departments of Neurobiology and Psychiatry and the NeuroNexus Institute at UMass Chan Medical School on Saturday, Feb. 5, the annual Brain Bee competition was created to encourage high school students to learn more about the neurosciences.

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  • UMass Chan ALS paper selected for STAT Madness

    UMass Chan ALS paper selected for STAT Madness

    Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues showed the ability to suppress mutant forms of the ALS gene known as C9ORF72 in a single-patient pilot study. The paper reporting the results is part of the 2022 STAT News STAT Madness competition.

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  • First gene therapy for Tay-Sachs disease successfully given to two children

    First gene therapy for Tay-Sachs disease successfully given to two children

    In a piece written for The Conversation, Miguel Sena-Esteves, PhD, talks about research leading to the first ever gene therapy for Tay-Sachs disease and the launch of the Translational Institute for Molecular Therapeutics at UMass Chan.

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  • Raiden Science Foundation makes gift to UMass Chan for UBA5 gene therapy research

    Raiden Science Foundation makes gift to UMass Chan for UBA5 gene therapy research

    An Oregon couple whose baby was diagnosed with an ultra-rare genetic disorder has launched a foundation to raise money to accelerate development of therapies for the condition and recently signed a gift agreement with UMass Chan Medical School to jump start the research.

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  • UMass Chan launches Translational Institute for Molecular Therapeutics

    UMass Chan launches Translational Institute for Molecular Therapeutics

    The Translational Institute for Molecular Therapeutics leverages UMass Chan Medical School’s extensive experience in researching and developing gene therapies for early-stage clinical trials. Miguel Sena-Esteves, PhD, is director of the new institute.

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  • UMass Chan clinical trial shows antisense oligonucleotide safely suppresses mutant ALS gene in pilot human study

    UMass Chan clinical trial shows antisense oligonucleotide safely suppresses mutant ALS gene in pilot human study

    Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene in a single-patient pilot study.

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  • Sio Gene Therapies reports positive interim data for gene therapy trial

    Sio Gene Therapies reports positive interim data for gene therapy trial

    Sio Gene Therapies, a clinical-stage company focused on developing gene therapies for neurodegenerative diseases, presented positive interim data from its Phase I/II study of AXO-AAV-GM1, an adeno-associated viral vector-based gene therapy candidate for GM1 gangliosidosis that was licensed from UMass Chan.

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  • Riaan Research Initiative funds Cockayne syndrome gene replacement therapy research at UMass Chan Medical School

    Riaan Research Initiative funds Cockayne syndrome gene replacement therapy research at UMass Chan Medical School

    Riaan Research Initiative, a non-profit organization, and UMass Chan Medical School are entering into an agreement to fund, research and develop a gene replacement therapy to combat Cockayne syndrome, a fatal autosomal recessive disorder.

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  • Two new studies from Daryl Bosco lab shed new light on ALS mechanisms

    Two new studies from Daryl Bosco lab shed new light on ALS mechanisms

    Two studies from the lab of Daryl Bosco, PhD, offer new insights into the biochemical and molecular mechanisms that cause amyotrophic lateral sclerosis.

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  • UMass ALS Cellucci Fund Boston Marathon team targets $50K goal for 10th anniversary

    UMass ALS Cellucci Fund Boston Marathon team targets $50K goal for 10th anniversary

    Five runners are participating in the 125th running of the Boston Marathon on Oct. 11 to raise money for UMass Medical School’s ALS Cellucci Fund.

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  • Four interdisciplinary collaborations share mission to demystify devastating brain disorders

    Four interdisciplinary collaborations share mission to demystify devastating brain disorders

    The Dan and Diane Riccio Fund for Neuroscience has awarded four teams of UMass Medical School researchers $50,000 seed grants for interdisciplinary collaborations leading to innovative discoveries that deepen understanding of normal brain function and what goes awry in neurological diseases.

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  • BRIDGE grants support research into rare Sialidosis disease and patch to prevent pressure ulcers

    BRIDGE grants support research into rare Sialidosis disease and patch to prevent pressure ulcers

    Heather Gray-Edwards, PhD, DVM; Miguel Sena-Esteves, PhD; and Raymond Dunn, MD, are the recipients of the Office of Business Development & Innovation 2021 BRIDGE Fund grants.

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  • USA Today reports on first baby in gene therapy clinical trial for Sandhoff, Tay-Sachs diseases

    USA Today reports on first baby in gene therapy clinical trial for Sandhoff, Tay-Sachs diseases

    Thomas Feldborg and Daria Rokina, of Denmark, chose to enroll their baby daughter, Alissa, in an investigational gene therapy for the treatment of GM2 gangliosidosis, which causes Tay-Sachs and Sandhoff diseases, to “let hope conquer the fears,” according to a report in USA Today chronicling their journey.

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  • FDA clears investigational new drug application for ALS gene therapy candidate

    FDA clears investigational new drug application for ALS gene therapy candidate

    Apic Bio, a gene therapy company developing treatment options for patients with rare genetic diseases and co-founded by UMass Medical School’s Robert H. Brown Jr., DPhil, MD, announced that the FDA has cleared its investigational new drug application for APB-102, a gene therapy candidate designed to treat a common cause of familial amyotrophic lateral sclerosis.

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  • High school senior Neil Kale wins 15th annual Central Massachusetts Brain Bee

    High school senior Neil Kale wins 15th annual Central Massachusetts Brain Bee

    The annual event, designed to stimulate high school students’ interest in neuroscience, was hosted by the Departments of Psychiatry and Neurology and the NeuroNexus Institute at UMass Medical School via Zoom on Saturday, March 20.

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  • Registration open for Brain Bee competition for local high school students

    Registration open for Brain Bee competition for local high school students

    The 15th annual Brain Bee competition for Massachusetts high school students will be hosted by the Departments of Psychiatry and Neurology and the NeuroNexus Institute at UMass Medical School via Zoom.

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  • Innovative neurosurgical technique used in Tay-Sachs gene therapy clinical trial

    Innovative neurosurgical technique used in Tay-Sachs gene therapy clinical trial

    Oguz Cataltepe, MD, describes the innovative neurosurgical procedure used to treat patients in the new clinical trial for a gene therapy targeting infantile Tay-Sachs and Sandhoff diseases.

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  • First patient dosed in clinical trial of gene therapy for Tay-Sachs and Sandhoff diseases

    First patient dosed in clinical trial of gene therapy for Tay-Sachs and Sandhoff diseases

    Sio Gene Therapies announced that the first patient with infantile Tay-Sachs disease has been dosed in a Phase I/II trial evaluating AXO-AAV-GM2, an investigational gene therapy for the treatment of GM2 gangliosidosis, which causes Tay-Sachs and Sandhoff diseases. Miguel Sena-Esteves, PhD, is a principal scientist of the research program at UMMS.

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  • FDA clears IND application for Tay-Sachs gene therapy

    FDA clears IND application for Tay-Sachs gene therapy

    Axovant Gene Therapies, a clinical-stage company developing innovative gene therapies based on UMass Medical School research discoveries, has announced that the FDA has lifted its clinical hold and cleared Axovant’s Investigational New Drug application to initiate a registrational study of gene therapy to treat patients with Tay-Sachs disease and Sandhoff disease.

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  • UMass Medical School community mourns loss of Jake Kennedy

    UMass Medical School community mourns loss of Jake Kennedy

    On behalf of the UMass Medical School community, we extend our sincere condolences to Jake Kennedy’s family and to all who knew and loved him. Jake Kennedy died Tuesday, Oct. 13, at age 65, in his Salem, N.H., home of amyotrophic lateral sclerosis.

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  • UMass ALS Cellucci team ready to run virtual Boston Marathon

    UMass ALS Cellucci team ready to run virtual Boston Marathon

    Jonathan Smith, of Worcester; Alyssa Smith, of Woodstock, Vt.; and Jennifer Bolanos, of Wilmington, are running the virtual Boston Marathon to support the UMass ALS Cellucci Fund.

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  • Silencing of an ALS gene safely delivered to patients in UMass Medical School study

    Silencing of an ALS gene safely delivered to patients in UMass Medical School study

    UMass Medical School and Massachusetts General Hospital are the first to safely treat two research participants with a synthetic microRNA, delivered into the spinal fluid, designed to silence a human disease-causing gene. Details of the treatment appear in the New England Journal of Medicine.

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  • UMass Chan student and SACNAS leader inspiring young women to find a passion for science

    UMMS student and SACNAS leader inspiring young women to find a passion for science

    Salome Funes, PhD candidate in the Graduate School of Biomedical Sciences, and the Society for the Advancement of Chicanos and Native Americans in Science are reaching out to organizations like Girls Inc. to teach young women about careers in science.

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  • LISTEN: Exploring new research into Parkinson’s disease

    LISTEN: Exploring new research into Parkinson’s disease

    In a new Voices of UMassMed podcast, Kara Smith, MD, talks about early warning signs of Parkinson’s disease and new developments in research.

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  • Angel Fund contributes $1 million for ALS research at UMass Medical School

    Angel Fund contributes $1 million for ALS research at UMass Medical School

    The Angel Fund for ALS Research donated $1 million last year to support the research of Robert H. Brown Jr., DPhil, MD. The sole mission of the nonprofit organization is to find a treatment and cure for ALS.

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