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Reviews and Commentaries

Goodwin, E., Jacobson, A., Weetall, M., Graci, J.D., Welch, E.M., O’Keefe, K., and Peltz, S.W. Dual mechanism of action of PTC299 and other DHODH inhibitors in suppressing SARS-CoV-2 replication and cellular cytokine storms. J. Cytokine Biol. 6: 10037, 2021.

Celik, A., He, F., and Jacobson, A. NMD monitors translational fidelity 24/7. Current Genet. 63: 1007-1010, 2017.

Jacobson, A. Methods to our madness. RNA 21: 529-530, 2015. 

Celik, A., Kervestin, S., and Jacobson, A. NMD: at the crossroads between translation termination and ribosome recycling. Biochimie 114: 2-9, 2015

He, F. and Jacobson, A. Nonsense-mediated mRNA decay: degradation of defective transcripts is only part of the story. Ann. Rev. Genetics 49: 339-366, 2015.

Roy, B. and Jacobson, A. The intimate relationships of mRNA decay and translation. Trends Genet. 29: 691-699, 2013

Peltz, S.W., Welch, E. M., Morsy, M., and Jacobson, A. Ataluren as an agent for therapeutic nonsense suppression. Ann. Rev. Med. 64: 407-425, 2013.

Kervestin, S. and Jacobson, A. NMD: a multifaceted response to premature translational termination. Nature Rev. Mol. Cell Biol. 13: 700-712, 2012.

Peltz, S.W., Welch, E.M., Trotta, C.R., Davis, T., and Jacobson, A. Targeting post-transcriptional control for drug discovery. RNA Biol. 6: 329-334, 2009.

Jacobson, A. and Izaurralde, E. Nonsense-mediated mRNA decay: from yeast to metazoans. In: Translational Control in Biology and Medicine (Eds.: Sonenberg, N., Mathews, M., and Hershey, J.), Cold Spring Harbor Laboratory Press, NY, pp. 655-687, 2007. 

Amrani, N., Sachs, M.S., and Jacobson, A. Early nonsense: mRNA decay solves a translational problem. Nature Rev. Mol. Cell Biol. 7: 415-425, 2006.

Amrani, N. and Jacobson, A. All termination events are not equal: premature termination in yeast is aberrant and triggers NMD. In: Nonsense-mediated mRNA decay (Editor: L.E. Maquat), Landes Bioscience, Texas, pp. 15-25, 2006.

He, F. and Jacobson, A. Endogenous substrates of the yeast NMD pathway. In: Nonsense-mediated mRNA decay (Editor: L.E. Maquat), Landes Bioscience, Texas, pp. 27-41, 2006.

Amrani, N., Dong, S., He, F., Ganesan, R., Ghosh, S., Kervestin, S., Li, C., Mangus, D.A., Spatrick, P., and Jacobson, A. Aberrant termination triggers nonsense-mediated mRNA decay. Biochem. Soc. Transact. 34: 39-42, 2006.

Mangus, D.A., Evans, M.C., and Jacobson, A. Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. Genome Biol. 4: 223.1-223.14, 2003.

Jacobson, A. and Peltz, S.W. Destabilization of nonsense-containing transcripts in Saccharomyces cerevisiae. In: Translational Control, Second Edition (Eds: N. Sonenberg, J.W.B. Hershey and M.B. Mathews), Cold Spring Harbor Laboratory Press, N.Y., pp. 827-847, 2000.

Hennigan, A.N. and Jacobson, A. A genetic approach to mapping coding region determinants of mRNA instability in yeast. In: mRNA Formation and Function (Ed.: Joel D. Richter), Academic Press, San Diego, pp. 149-161, 1997.

Jacobson, A. Poly(A) metabolism and translation: the closed loop model. In: Translational Control (Eds: J.W.B. Hershey, M.B. Mathews, and N. Sonenberg), Cold Spring Harbor Laboratory Press, N.Y. pp. 451-480, 1996.

Jacobson, A. and Peltz, S.W. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Ann. Rev. Biochem. 65: 693-740, 1996. 

Peltz, S.W., He, F., Welch, E., and Jacobson, A. Nonsense-mediated mRNA decay in yeast. Prog. Nucleic Acid Res. Mol. Biol. 47: 271-298, 1994.

Peltz, S.W. and Jacobson, A. mRNA turnover in Saccharomyces cerevisiae. In: Control of mRNA Stability (Eds: J. Belasco & G. Brawerman), Academic Press, pp. 291-328, 1993. 

Peltz, S.W., Trotta, C., Feng, H., Brown, A., Donahue, J., Welch, E., and Jacobson, A. Identification of the cis-acting sequences and trans-acting factors involved in nonsense-mediated mRNA decay. In: Protein Synthesis and Targeting in Yeast (Eds: A. Brown, M. Tuite, and J. McCarthy), Springer-Verlag, pp. 1-10, 1993.

Munroe, D. and Jacobson, A. Poly(A) is a 3' enhancer of translational initiation. In Structure, Function, and Evolution of Ribosomes (Ed. W. Hill), ASM Press, pp. 299-305, 1990. 

Munroe, D. and Jacobson, A. Tales of poly(A)-a review. Gene 91: 151-158, 1990.

Munroe, D. and Jacobson, A.  Involvement of 3'-poly(A) tracts in protein synthesis: a role in mRNP assembly. In Molecular Biology of RNA (Ed. T.R. Cech), Alan R. Liss, Inc., pp. 257-269, 1989. 

Steel, L.F. and Jacobson, A. Post-transcriptional regulation of ribosomal protein gene expression during development in Dictyostelium discoideum. Devel. Genetics 9: 421-434, 1988. 

Manrow, R.E., Shapiro, R.A., Herrick, D., Steel, L.F., Blinder, D., and Jacobson, A. Regulation of mRNA stability and the poly(A) problem in Dictyostelium discoideum. Devel. Genetics 9: 403-419, 1988. 

Jacobson, A. and H.F. Lodish.  Genetic control of development of the cellular slime mold, Dictyostelium discoideum, Ann. Rev. Genetics 9: 145-185, 1975. 

Lodish, H.F., A. Jacobson, R.A. Firtel, T. Alton and J. Tuchman.  Synthesis of messenger RNA and chromosome structure of the cellular slime mold.  Proc. Natl. Acad. Sci. U.S. 71: 5103-5108, 1974.

Firtel, R.A., A. Jacobson, J. Tuchman and H.F. Lodish.  Gene activity during development of the cellular slime mold, Dictyostelium discoideumGenetics 78: 355-372, 1974.

Lodish, H.F., R.A. Firtel and A. Jacobson.  Transcription and structure of the genome of the cellular slime mold, Dictyostelium discoideumCold Spring Harbor Symp. Quant. Biol. 38: 899-914, 1973.

Lodish, H.F. and A. Jacobson.  Translational control of protein synthesis in eukaryotic cells: Is there tissue or species specificity of the translational apparatus?  Develop. Biol. 27: 283-285, 1972.