For the latest COVID-19 campus news and resources, visit

Search Close Search
Search Close Search
Page Menu

Poly(A), PABP, and the Closed-loop Model

Mangkalaphiban, K., He, F., Ganesan, R., Wu, C., Baker, R., and Jacobson, A. Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. PLoS Genetics 17: e1009538, 2021.

Mangkalaphiban, K., He, F., Ganesan, R., Wu, C., Baker, R., and Jacobson, A. Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. bioRxiv 2020.12.15.422930; doi:

Wu, C., Roy, B., He, F., Yan, K., Jacobson, A. Poly(A)-binding protein regulates the efficiency of translation termination. Cell Reports 33: 108399, 2020.

Amrani, N., Ghosh, S., Mangus, D.A., and Jacobson, A. Translation factors promote formation of two states of the closed loop mRNP. Nature 453: 1276-1280, 2008.

Mangus, D.A., Smith, M., McSweeney, J.M., and Jacobson, A. Identification of factors regulating poly(A) tail synthesis and maturation. Mol. Cell. Biol. 24: 4196-4206, 2004. 

Mangus, D.A., Evans, M.C., Agrin, N.S., Smith, M., Gongidi, P., and Jacobson, A. Positive and negative regulation of poly(A) nuclease. Mol. Cell. Biol. 24: 5521-5533, 2004.

Duvel, K., Valerius, O., Mangus, D.A., Jacobson, A., and Braus, G.H. Replacement of the yeast TRP4 3' untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail. RNA 8: 336-344, 2002.

Knight, J.E., Narus, E.N., Martin, S.L., Jacobson, A., Barnes, B.M., and Boyer, B.B. mRNA stability and translational inhibition in hibernating arctic ground squirrels (Spermophilus parryii). Mol. Cell. Biol. 20: 6374-6379, 2000.

Mangus, D.A., Amrani, N., and Jacobson, A. Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation. Mol. Cell. Biol. 18: 7383-7396, 1998.

Munroe, D. and Jacobson, A. mRNA poly(A) tail: a 3' enhancer of translational initiation. Mol. Cell. Biol. 10: 3441-3455, 1990.

Shapiro, R.A., Herrick, D., Manrow, R., Blinder, D., and Jacobson, A.  Determinants of mRNA stability in Dictyostelium discoideum amoebae:  differences in poly(A) tail length, ribosome loading, and mRNA size cannot account for the heterogeneity of mRNA decay rates. Mol. Cell. Biol. 8: 1957-1969, 1988.

Manrow, R.E. and Jacobson, A.  Increased rates of decay and reduced levels of accumulation of the major poly(A)-associated proteins of Dictyostelium during heat-shock and development.  Proc. Natl. Acad. Sci. USA 84: 1858-1862, 1987.

Palatnik, C.M., Wilkins, C. and Jacobson, A.  Translational control during early Dictyostelium development:  possible involvement of poly(A) sequences.  Cell 36: 1017-1025, 1984.

Jacobson, A. and Favreau, M.  Possible Involvement of Poly(A) in Protein Synthesis. Nucleic Acids Res. 11: 6353-6368, 1983.

Palatnik, C.M., A.K. Capone, R.V. Storti and A. Jacobson.  Messenger RNA stability in Dictyostelium discoideum:  Does poly (A) have a regulatory role?  J. Mol. Biol. 141: 99-118, 1980.

Palatnik, C.M., R.V. Storti and A. Jacobson.  Fractionation and functional analysis of newly synthesized and decaying messenger RNAs from vegetative cells of Dictyostelium discoideumJ. Mol. Biol. 128: 371-397, 1979.

Firtel, R., A. Jacobson, and H.F. Lodish.  Isolation and hybridization of messenger RNA from the cellular slime mold, Dictyostelium discoideumNature 239: 225-228, 1972.