Victor Ambros has won the 2024 Nobel Prize in Physiology or Medicine!

Search Close Search
Search Close Search
Page Menu

Drug Development

Luban, J., Sattler, R., Mühlberger, E., Graci, J.D., Cao, L., Weetall, M., Trotta, C., Colacino,J.M., Bavari, S., Strambio-De-Castillia, C., Suder, E.L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N.A., Pykett, M., Welch, E.M., O’Keefe, K., Kong, R., Goodwin, E., Jacobson, A., Paessler, S., and Peltz, S. The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines. Virus Research 292:198246, 2021.

Cao, L., Weetall, M., Trotta, C., Cintron, K., Ma, M., Kim, M.-J., Furia, B., Romfo, C.,  Graci, J.D., Li, W., Du, J., Sheedy, J., Hedrick, J., Risher, N., Yeh, S., Qi, H., Arasu, T., Hwang, S., Lennox, W., Ingolia, N.T., Kong, R., Petruska, J., Moon, Y.-C., Babiak, J.,  Almstead, N.G., Davis, T.W., Jacobson, A., Branstrom, A., Colacino, J.M., and Peltz, S.W. Targeting of hematologic malignancies with PTC299, a novel potent inhibitor of dihydroorotate dehydrogenase with favorable pharmaceutical properties. Molec. Cancer Therap. 18: 3-16, 2019.

Welch, E.M., Barton, E.R., Zhuo, J., Tomizawa, Y, Friesen, W.J., Trifillis, P., Paushkin, S.,  Patel, M., Trotta, C.R., Hwang, S., Wilde, R.G., Karp, G., Takasugi, J., Chen, G., Jones, S., Ren, H., Moon, Y.-C., Corson, D., Turpoff, A.A., Campbell, J.A., Conn, M.M., Khan, A.,  Almstead, N.G., Hedrick, J., Molin, A., Risher, N., Weetall, M., Yeh, S., Branstrom, A.A.,  Colacino, J.M., Babiak, J., Ju, W.D., Hirawat, S., Northcutt, V.J., Miller, L.L., Spatrick, P., He, F., Kawana, M., Feng, H., Jacobson, A., Peltz, S.W., & Sweeney, H.L. PTC124 targets genetic disorders caused by nonsense mutations. Nature 447: 87-91, 2007.