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mRNA Decapping and Decay

He, F., Celik, A., and Jacobson, A. General decapping activators target different subsets of inefficiently translated mRNAs. eLife 7: e34409, 2018.

He, F. and Jacobson, A. Control of mRNA decapping by positive and negative regulatory elements in the C-terminal domain of Dcp2. RNA 21: 1633-1647, 2015.

He, F., Li, C., Roy, B., and Jacobson, A. Yeast Edc3 targets RPS28B mRNA for decapping by binding to a 3’-UTR decay-inducing regulatory element. Mol. Cell. Biol. 34: 1438-1451, 2014.

Dong, S., Jacobson, A., and He, F. Degradation of YRA1 pre-mRNA in the cytoplasm requires translational repression, multiple intronic modular elements, Edc3p, and Mex67p. PLoS Biology 8: e1000360, 2010.

Dong, S., Li, C., Zenklusen, D., Singer, R.H., Jacobson, A., and He, F. YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA. Molec. Cell 25: 559-573, 2007.

He, F. and Jacobson, A. Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs Mol. Cell. Biol. 21: 1515-1530, 2001.

Zuk, D. and Jacobson, A. A single amino acid substitution in yeast eIF-5A results in mRNA stabilization. EMBO J. 17: 2914-2925, 1998.

Hennigan, A.N. and Jacobson, A. Functional mapping of the translation-dependent instability element of the yeast MATα1 mRNA. Mol. Cell. Biol. 16: 3833-3843, 1996.

Herrick, D. and Jacobson, A. A coding region segment is necessary but not sufficient for rapid decay of the HIS3 mRNA in yeast. Gene 114: 35-41, 1992. 

Parker, R. and Jacobson, A. Translation and a forty-two nucleotide segment within the coding region of the mRNA encoded by the MATα1 gene are involved in promoting rapid mRNA decay in yeast. Proc. Natl. Acad. Sci. USA 87: 2780-2784, 1990.

Herrick, D., Parker, R., and Jacobson, A. Identification and comparison of stable and unstable mRNAs in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 10: 2269-2284, 1990.