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Publications

Published work covers a broad range of topics from COVID-19 to Elder Microbiome, Bacterial Infections, and Gut-Brain Axis

Recent Publications

COVID-19

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long-COVID. https://insight.jci.org/articles/view/152346

Clinical Studies to Assess the Natural History and Impact of Gut Microbiome Modulation in Non-Hospitalized Patients with Mild to Moderate COVID-19 a Randomized, Open-Label, Prospective Study with a Parallel Group Study Evaluating the Physiologic Effects of KB109 on Gut Microbiota Structure and Function: A Structured Summary of a Study Protocol for a randomized controlled study. https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05157-0

Vaccine Effectiveness Among Healthcare Personnel Study Team. Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel - 33 U.S. Sites, January-March 2021. https://pubmed.ncbi.nlm.nih.gov/34014909/

Symptoms of anxiety, burnout, and PTSD and the mitigation effect of serologic testing in emergency department personnel during the COVID-19 pandemic. https://pubmed.ncbi.nlm.nih.gov/33846014/

Diagnosed and Undiagnosed COVID-19 in US Emergency Department Health Care Personnel: A Cross-sectional Analysis. https://pubmed.ncbi.nlm.nih.gov/33771413/  

Vaccination rates and acceptance of SARS-CoV-2 vaccination among U.S. emergency department health care personnel. https://pubmed.ncbi.nlm.nih.gov/33608937/

Elder Microbiome

The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and is Influenced by Medication Exposures, Age, Environment, and Frailty. https://pubmed.ncbi.nlm.nih.gov/34125200/

Aging, Frailty, and the Microbiome: How Dysbiosis Influences Human Aging and Disease. https://pubmed.ncbi.nlm.nih.gov/33307030/

High-dimensional causal mediation analysis with a large number of mediators clumping at zero to assess the contribution of the microbiome to the risk of bacterial pathogen colonization in older adults. https://www.eurekaselect.com/node/176746/article/high-dimensional-causal-mediation-analysis-with-a-large-number-of-mediators-clumping-at-zero-to-assess-the-contribution-of-the-microbiome-to-the-risk-of-bacterial-pathogen-colonization-in-older-adults

The nursing home elder microbiome stability and associations with age, frailty, nutrition, and physical location.  https://pubmed.ncbi.nlm.nih.gov/29134939/

The Urinary Microbiome of Older Adults Residing in a Nursing Home Varies with Duration of Residence and Shows Increases in Potential Pathogens. https://pubmed.ncbi.nlm.nih.gov/34791238/

Pathogens/Infections

The High Prevalence of Clostridioides difficile among Nursing Home Elders Associates with a Dysbiotic Microbiome. Gut Microbes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007149/

Reduction of inappropriate antibiotic use and improved outcomes by implementation of an algorithm based clinical guideline for non-purulent skin and soft tissue infections. https://doi.org/10.1016/j.annemergmed.2019.12.012

Proton pump inhibitors and 180-day mortality in the elderly after Clostridium difficile treatment. https://pubmed.ncbi.nlm.nih.gov/31210787/

Deviating from IDSA treatment guidelines for non-purulent skin infections increases the risk of treatment failure in emergency department patients. https://pubmed.ncbi.nlm.nih.gov/30516120/

Macrolide resistance in cases of community-acquired bacterial pneumonia in the emergency department. https://pubmed.ncbi.nlm.nih.gov/29789175/

Medication exposure and the risk of recurrent Clostridium difficile Infection in community-dwelling older people and nursing home residents. https://pubmed.ncbi.nlm.nih.gov/29120481/

Elderly patients are at increased risk for treatment failure in outpatient management of purulent skin infections. Am https://pubmed.ncbi.nlm.nih.gov/27836315/

Antibiotic-associated diarrhoea in emergency department observation unit patients. https://pubmed.ncbi.nlm.nih.gov/27324463/

Treatment of bacterial skin infections in ED observation units: factors influencing prescribing practice. https://pubmed.ncbi.nlm.nih.gov/26381681/

Factors Influencing the Development of Antibiotic Associated Diarrhea in ED Patients Discharged Home: Risk of Administering Intravenous Antibiotics. https://pubmed.ncbi.nlm.nih.gov/25149599/

Gut-Brain Axis

Alzheimer’s disease microbiome is associated with dysregulation of the anti-inflammatory P-glycoprotein pathway. https://pubmed.ncbi.nlm.nih.gov/31064831/

Gut Microbiota Regulate Alzheimer’s Disease Pathologies and Cognitive Disorders via PUFA-Associated Neuroinflammation. https://pubmed.ncbi.nlm.nih.gov/35017199/

In the News

Recent Non-Peer Reviewed Work and News Articles Below

Jim Fessenden. UMMS helps gather data leading to eased CDC guidelines for fully vaccinated individuals. UMassMed News. https://www.umassmed.edu/news/news-archives/2021/05/umms-helps-gather-data-leading-to-eased-cdc-guidelines-for-fully-vaccinated-individuals/. May 26, 2021

Jim Fessenden. Beth McCormick, John Haran work with Kaleido Biosciences to explore link between microbiome and COVID-19. UMassMed News. https://www.umassmed.edu/news/news-archives/2020/05/beth-mccormick-john-haran-work-with-kaleido-biosciences-to-explore-link-between-microbiome-and-covid-19/?fbclid=IwAR0VH7sI2VYVLYzjY-fTZ31YvfI_2iiwQFwWnmXjC-WtzAAPt1z-pOKtuMo. May 15, 2020

Michael Bonner, Mass Medical School will enroll 260 Worcester-area seniors in Alzheimer’s study to help researchers understand how diet may help combat the disease. Mass Live. https://www.masslive.com/worcester/2020/09/umass-medical-school-will-enroll-260-worcester-area-seniors-in-alzheimers-study-to-help-researchers-understand-how-diet-may-help-combat-the-disease.html. Sept. 29, 2020

Lisa M. Larson. John Haran works to understand how microbiome impacts development of Alzheimer’s disease. UMassMed News. https://www.umassmed.edu/news/news-archives/2019/11/john-haran-works-to-understand-how-microbiome-impacts-development-of-alzheimers-disease/. Nov. 6, 2019

Haran JP, Zheng Y, Knobil K, Palma NA, Lawrence JF, Wingertzahn MA. Targeting the Microbiome With KB109 in Outpatients with Mild to Moderate COVID-19 Reduced Medically Attended Acute Care Visits and Improved Symptom Duration in Patients With Comorbidities. medRxiv 2021.03.26.21254422; doi: https://doi.org/10.1101/2021.03.26.21254422

Sandra Gray. John Haran focusing on microbiome to understand C. difficile in nursing homes. UMassMed News. https://www.umassmed.edu/news/news-archives/2018/09/john-haran-focusing-on-microbiome-to-understand-c.-difficile-in-nursing-homes/. Sept. 7, 2018

Rachel Lutz. Surprising Added Risk for Clostridium difficile in Elderly Patients. MD Magazine. December 14, 2017

Angus Chen. C. Diff Infections are Falling, Thanks to Better Cleaning and Fewer Antibiotics. Shots, Heath News from NPR (National Public Radio). June 29, 2017

Genna Rollins. Fast-tracking Definitive Diagnosis of Influenza-like Illness in the Emergency Department; C-reactive Protein Shown to be Sensitive, Specific Marker for Bacterial Infection. Clinical Laboratory Strategies. Feb 14, 2013

Keng Sheng Chew, What’s new in Emergencies Trauma and Shock? C-reactive protein as a potential clinical biomarker for influenza infection: More questions than answers. Journal of Emergencies, Trauma, and Shock. April-June; 5(2): 115-17 (2012)

Daily Breaking News, WCCATV 194. https://www.wccatv.com/video/daily-breaking/dailybreaking-130. January 7, 2021

Emily Riemer, Researchers study link between gut health, Alzheimer's. WCVB Channel 5. https://www.wcvb.com/article/researchers-study-link-between-gut-health-alzheimer-s/34305626. October 7, 2020.