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Zoonomia

Friday, April 28, 2023
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By:  Haley R Barlow, PhD

Check out this Twitter/X thread highlighting work published by the members of the Zoonomia consortium, including our own Dr. Zhiping Weng.

a tweet that reads: Check out the work of what literally seems like HUNDREDS of scientists in this special issue of @sciencemagazine using the genome sequencing of over 200 mammals (#zoonomia) to uncover secrets of evolution and more! and a picture of the cover of science depicting 5 different animals1/10 Researchers developed a new tool called TACIT that can be used to identify genetic enhancers associated with the #evolution of any convergently evolved phenotype (!!!)2/10 Researchers compared the genomes of 240 mammals to that of humans to ID regions that are important in #disease. Looking at evolutionary constraint, they ID’d 3.3% of the human genome for future study.3/10 Heist! Researchers ID’d parts of the human genome that evolved quickly and used information about the 3D organization of DNA to discover “enhancer hijacking” as a driver of rapid #human evolution4/10 The team developed a new tool called TOGA (Tool to infer Orthologs from Genome Alignments) that is the largest comparative genome resource in existence!!!5/10 We previously featured this as a #preprint alert! Check it out here: "Evolutionary constraint & innovation across 100s of placental mammals"6/10 Researchers found that most human-specific deletions might affect brain function. Which genes might make human brains different from other brains? Check it out!7/10 Remember the famous dog sled dog, Balto? These researchers sure do! They analyzed his genome compared to modern #dog and #wolf genomes to find out what made Balto so special. Check it out here!8/10 The team lays out a timeline for placental mammal evolution and expansion right after the Cretaceous-Paleogene boundary (~66 million years ago) AKA the extinction of non-avian #dinosaurs9/10 The team uses the power of #computerscience and data from the #zoonomia consortium to make new discoveries about how gene expression is regulated in the human genome10/10 the historical size of a species population is correlated with #extinction risk (smaller population=higher risk of extinction) via the accumulation of deleterious genomic content

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