Metabolism Core
The Metabolism Core conducts specialized and non-invasive metabolic experiments to measure insulin sensitivity, glucose/lipid/protein metabolism, pancreatic β-cell function, body composition and energy balance. Most experiments are performed under physiological state and in conscious mice. The Core services include:
- Hyperinsulinemic-euglycemic clamp to assess insulin sensitivity and glucose metabolism in awake mice (method)
- Hyperglycemic clamp to assess insulin secretion and pancreatic beta cell function in awake mice (method)
- Glucose tolerance test (GTT) and insulin tolerance test (ITT) (method)
- Glucose, lipid and protein metabolism in individual organs in vivo using labeled metabolites in awake mice (method)
- Non-invasive measurement of whole body and tissue composition of fat, lean and water mass
using 1-MRS (method) - Non-invasive assessment of energy balance including food/water intake, energy expenditure, respiratory exchange ratio, and physical activity using metabolic cages with temperature and light control (method)
- Exercise study using treadmill with acute, chronic endurance, and exhaustive exercise protocols and using in-house cage wheels
- Drug trial studies (blinded) involving test compounds and metabolic experiments
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Survival surgery of jugular vein cannulation for in vivo experiments (method)
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Chronic and acute induction of obesity, insulin resistance and diabetes using high-fat diet, lipid infusion, streptozotocin injection and phloridzin treatment (method)
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Osmotic pump implantation for chronic delivery of drugs and compounds (method)
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Director
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Co-Director Roger J. Davis, Ph.D.
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Co-Director |
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Address: University of Massachusetts Chan Medical School |