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Metabolism Core

The Metabolism Core conducts specialized and non-invasive metabolic experiments to measure insulin sensitivity, glucose/lipid/protein metabolism, pancreatic β-cell function, body composition and energy balance. Most experiments are performed under physiological state and in conscious mice. The Core services include:

  • Hyperinsulinemic-euglycemic clamp to assess insulin sensitivity and glucose metabolism in awake mice (method)
  • Hyperglycemic clamp to assess insulin secretion and pancreatic beta cell function in awake mice (method)
  • Glucose tolerance test (GTT) and insulin tolerance test (ITT) (method)
  • Glucose, lipid and protein metabolism in individual organs in vivo using labeled metabolites in awake mice (method)
  • Non-invasive measurement of whole body and tissue composition of fat, lean and water mass
        using 1-MRS (method)
  • Non-invasive assessment of energy balance including food/water intake, energy expenditure, respiratory exchange ratio, and physical activity using metabolic cages with temperature and light control (method)
  • Exercise study using treadmill with acute, chronic endurance, and exhaustive exercise protocols and using in-house cage wheels
  • Drug trial studies (blinded) involving test compounds and metabolic experiments
  • Survival surgery of jugular vein cannulation for in vivo experiments (method)
  • Chronic and acute induction of obesity, insulin resistance and diabetes using high-fat diet, lipid infusion, streptozotocin injection and phloridzin treatment (method)
  • Osmotic pump implantation for chronic delivery of drugs and compounds (method)


Jason K. Kim, Ph.D. 
Professor of Molecular Medicine
Professor of Medicine, Division of Endocrinology, Metabolism & Diabetes
Albert Sherman Center, 9th Floor, Suite 1041
(508) 856-6807


jason Kim


Roger J. Davis, Ph.D.
H. Arthur Smith Chair and Professor of Molecular Medicine
HHMI Investigator
Biotech Two, Suite 309
(508) 856-6054


 Roger Davis


Lauren Tauer, M.S. 
Research Specialist
Albert Sherman Center, 9th Floor, Suite 1015
(774) 455-3786


University of Massachusetts Chan Medical School
368 Plantation Street
Albert Sherman Center, 9th Floor, Suite 1041
Worcester, MA 01605


Overview Mice2