Ongoing Grants:
The OAI Collaborative Osteoarthritis Research Enterprise (OAI CORE) Knowledgebase
Award Number: R24AR085006
Source of Support: NIH/NIAMS
Dates: 2025-2029
Objective: The goal of this project is to create a biomedical knowledgebase to extract, accumulate, organize, annotate, and link growing bodies of information related to the Osteoarthritis Initiative (OAI).
Environmental Factors Associated with the Development of Osteoarthritis
Award Number: R01AR08179
Source of Support: NIH/NIAMS
Dates: 2023-2027
Objective: To determine if a specific class of environmental pollutants increases the risk for hand osteoarthritis incidence and is related to greater changes in disease burden, articular cartilage, and bone.
Interpretation and Utility of Novel Composite Structural Endpoints of Cumulative Damage and Disease Activity in Knee Osteoarthritis
Award Number: R01AR076411
Source of Support: NIH/NIAMS
Dates: 2021-2030 (renewed)
Objective: Our long-term goal is to achieve FDA qualification of our MR-based composite metrics as biomarkers for use in KOA clinical trials. This renewal advances our goal by addressing FDA requests and expanding the context of use for our metrics to early KOA.
Prior Grants:
Radiofrequency Ablation for Chronic Knee Pain after Total Knee Arthroplasty (RACK TKA)
Source of Support: Rheumatology Research Foundation
Dates: 2022-2025
Objectives: The overall objective of this 6-month double-blinded, sham-controlled clinical trial is to assess the clinical usefulness of genicular nerve radiofrequency ablation for chronic pain after total knee arthroplasty performed for osteoarthritis.
Effects of Vitamin K on Lower-extremity Function in Adults with Osteoarthritis: a Randomized Controlled Pilot Trial
Award Number: (PI: Sarah Booth, Tufts University; Richard Loeser, UNC Chapel Hill)
Source of Support: NIH/NIAMS
Dates: 2022-2025
Objective: The overall goal of the project was to execute a randomized controlled pilot study in adults with mild to moderate knee OA and low baseline vitamin K status in order to address critical parameters required to design a larger clinical trial
DDT-BMQ-00086 End-Stage Knee Osteoarthritis as a Prognostic Biomarker for Knee Osteoarthritis Trials
Award Number: U01FD007471
Source of Support: US FDA
Dates: 2021-2023
Objective: The goal was to determine how a composite biomarker for end-stage knee osteoarthritis and its components relate to disease progression and predict a future knee replacement.
Longterm Effect Of Genicular Nerve Ablation on Knee Pain, Gait and Joint Structure
Award Number: R34 AR076625
Source of Support: NIH/NIAMS
Dates: 2020-2022
Objective: The goal of this R34 was to plan a rigorous clinical trial of RFA for knee OA pain utilizing contemporary, sophisticated, technologies to evaluate its short‐ and long‐term effects on pain, physical function, physical activity, gait, proprioception, joint loading, and knee structural health.
Cumulative Damage and Disease Activity Metrics as Prognostic Enrichment Imaging Biomarkers for Knee Osteoarthritis Trials
Award Number: U01FD007002
Source of Support: US FDA
Dates: 2020-2022
Objective: The goal of this project was to help enrich future clinical trials for knee osteoarthritis. We aimed to determine the best threshold for 2 novel measures of disease progression to optimize their ability to predict a future knee replacement.
Metabolites of Dietary Intake and Risk of Knee Osteoarthritis
Award Number: R01AR074447 (PI: Bing Lu, UConn Health)
Source of Support: NIH/NIAMS
Dates: 2019-2025
Objective: The overall objective was to assess whether individual diet-related metabolites and metabolomic profiles predict subsequent risk of knee OA, and examine how these metabolomic profiles influence imaging biomarkers of knee OA.
Biomarkers of Cartilage Turnover and Joint Metabolism Greater than One Year After Traumatic Knee Joint Injury and Signs of Early Post-Traumatic Osteoarthritis
Source of Support: Geneva Foundation (PI: Steve Svoboda, Keller Army Hospital)
Dates: 2016-2021
Objectives: The overall objective is to prospectively evaluate acute changes in biomarkers of cartilage turnover and joint metabolism following traumatic knee joint injury and surgical reconstruction in relation to imaging biomarkers at one and two years post injury, to better understand the impact of acute joint injury, as these may be important factors related to the initiation and progression of post-traumatic osteoarthritis.
Characterization of Rapidly Progressive Knee Osteoarthritis
Award Number: R01AR065977
Source of Support: NIH/NIAMS
Dates: 2015-2020
Objective: The goal of this project was to test whether accelerated knee osteoarthritis can be uniquely characterized by anatomical features, biochemical biomarkers, specific types of initiating pathology, and distinct pathological processes.
Constitutional and Metabolic Factors associated with the development of Hand OA
Award Number: R01AR066378
Source of Support: NIH/NIAMS
Dates: 2015-2020
Objective: The goal of this project was to evaluate and contrast the roles of structural and metabolic characteristics in the development of radiographic, symptomatic and erosive hand osteoarthritis.