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Research Interests


Synthetic tissue grafts and smart implants guiding the repair and regeneration of musculoskeletal tissues

With an aging population, the demand for synthetic tissue scaffolds assisting the repair and reconstruction of musculoskeletal tissue defects resulting from trauma, aging, cancer and metabolic diseases is \rising. Our lab is interested in 1) developing new biomaterial- and stem cell-based approaches towards bone and cartilage tissue regeneration, particularly dealing with hard-to-heal tissue defects resulting from aging, diabetes, and traumatic injuries; 2) identifying novel factors regulating stem cell renewal and skeletal tissue regeneration; 3) identifying new targets for the development of disease modifying drugs of osteoarthritis; and 4) improving the osteointegration of and reducing periprosthetic infections associated with existing orthopedic metallic implants. Many of the synthetic scaffolds we designed are programmed with unique physical properties to facilitate facile surgical delivery (injectable formulations; minimally invasive in vivo deployment), tunable & predictive in vivo degradation profiles, and spatially controlled presentation and temporally controlled release of bioactive factors for regulating stem/progenitor cell fate within the tissue niche environment.

jie research


B.S. 1995, Fudan University, P.R. China
Ph.D. 1999, Michigan State University
Postdoctoral Fellow 1999-2002, University of California Berkeley & Lawrence Berkeley National Laboratory
Staff Scientist 2002-2006, Lawrence Berkeley National Laboratory

Recent Publications

For a list of Dr Song publications, follow this link: 


Potential Rotation Projects

1. Design and evaluation of smart synthetic bone / cartilage tissue grafts

2. Metallic implant surface modifications for reducing periprosthetic infections

3. New therapeutic targets for the development of disease modifying drugs of osteoarthritis














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2017  ALSF Innovation Grant award, Alex's Lemonade Stand Foundation

2017  Bassick Family Foundation Award, Worcester Foundation/Hudson Hoagland Society

2015  J.R. Neff Award , Musculoskeletal Transplant Foundation

2014  Mel and Sandy Cutler Award, Worcester Foundation/Hudson Hoagland Society

2013  Dean’s Award for Research Mentoring and Commitment to Student Professional Advancement, GSBS/UMMS

2008  Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) Award, National Institutes of Health

2008  Career Enhancement Award, American Society for Bone and Mineral Research

2007  Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research

Other sponsors:

Musculoskeletal Transplant Foundation
American Society for Bone and Mineral Research
Massachusetts Technology Transfer Center
Worcester Foundation for Biomedical Research
President’s Office, University of Massachusetts
CVIP, University of Massachusetts
Clinical and Translational Science Pilot Project Program, UMMS
Life Science Moment Fund, UMMS

Lab Members



Song Lab members

Jie Song2

Jie Song, PhD


Faculty Appointment in:
  • Orthopedics and Physical Rehabilitation (Medicine)

Other Affiliations:

  • Interdisciplinary Graduate Program
  • Chemical Biology
  • MD/PhD Program

    Phone: 508 334 7168