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David Ayers Research Page

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Research Interests


Radiostereometric (RSA) Imaging of Hip Prostheses and Spine Fusion

  • Detection of early migration of the femoral component, wear of the liner, and cup/component loosening
  • 3-dimensional analysis of rotation and translation

rsa 1 rsa2




Total Knee Replacement (TKR) (David Ayers, Patricia Franklin)

  • Variation in post-op patient-reported function
  • Role of emotional health on physical function
  • Prediction models for level of function to guide patient decisions for surgery
  • Understand the role of activity and exercise in TKR functional outcomes


BS in Chemistry, Tufts University 1978

University of Rochester, School of Medicine and Dentistry, MD 1982

University of Rochester, Strong Memorial Hospital, Orthopedic Surgery Residency 1987

Recent Publications














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Pingsheng Liu, Jonathan Smits, David C. Ayers and Jie Song. Surface mineralization of Ti6Al4V with calcium apatites for the retention and localized delivery of rhBMP-2. Acta Biomaterialia 2011 2011, 7, 3488-3495.

Tera M. Filion, Xinning Li, April Mason-Savas, Jaclynn M. Kreider, Steven A. Goldstein, David C. Ayers and Jie Song. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng. Part A 2011, 17 (3-4), 503-511.

Franklin PD, Karbassi JA, Li W, Yang W, Ayers DC. Reduction in narcotic use after primary Total Knee Replacement associated with pain relief and satisfaction. J Arthroplasty. 2010 ; 25(6): 12-16. PMID: 20580191.

St.PierreC, Chan M, Iwakura Y, Ayers DC, Kurt-Jones EA. Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles. J Orthop Res. 2010 Jan; 28(11): 1418-24. PMID: 20872576.

Jie Song, Jianwen Xu, Tera Filion, Eduardo Saiz, Antoni P. Tomsia, Jane B. Lian, Gary S. Stein, David C. Ayers, and Carolyn R. Bertozzi. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications J. Biomed. Mater. Res. 2009, 89A (4)

Franklin PD, Li W, Ayers DC. The Chitranjan Ranawat Award: functional outcome after total knee replacement varies with patient attributes. Clin Orthop Relat Res, 2008 Nov;466(11):2597-604
Jager M, Urselmann F, White F, Zanger K, Li X, Ayers DC, Krauspe R. Osteoblast differentiation onto different biomaterials with an endoprosthetic surface topography in vitro. J. Biomed. material res. Part A. July 2008, 86A(1): 61-75

Jäger M, Fischer J, Dohrn W, Li X, Ayers DC, Czibere A, Prall WC, Lensing-Höhn S, Krauspe R. Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J. Orthop Res. 2008 Apr 10.

Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high mineral content hydrogel- hysroxyapatite composites for orthopedic applications. J. Biomed. Res. Mater. Res. 2008.






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"Define implant-related efficiencies and develop software to estimate hospital benefits and costs for the Zimmer Patient Specific Instruments (PSI)
Sponsor: Zimmer, Inc.
David Ayers, Principal Investigator; Patricia Franklin, CO-Investigator

"Patient Outcomes Registry for Clinical and Translational Research"  
Sponsor: UMMHC  
David Ayers, CO-Principal Investigator; Patricia Franklin, CO-Principal Investigator

"Opportunities and Challenges for Total Knee & Hip Replacement Surgery - A Collaborative Research of University of Massachusetts at Amherst and Worcester (Ayers/Crosby)"
Sponsor: UMass President's Science & Technology Award 
David Ayers, Principal Investigator; Jie Song, CO-Investigator

D Ayers

David Ayers, MD

Arthur M. Pappas, Chair, Orthopedics and Physical Rehabilitation, UMMHC
Professor of Orthopedics & Physical Rehabilitation, UMass Chan

Faculty Appointment in:
  • Orthopedics and Physical Rehabilitation (Medicine)
  • Family and Community Medicine (Medicine)
  • Morningside Graduate School of Biomedical Sciences
  • Clinical and Population Health Research (CPHR)

    Phone: 508 334 9750