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UMMS Deep Sequencing Core Labs logo

The Deep Sequencing Core Facility offers high-throughput sequencing and library-building services for the UMass campuses and outside customers. The facility operates several types of Illumina next-gen sequencers, and is closely integrated with the PacBio Core Enterprise and the Molecular Biology Core Labs. See the Services page for detailed run options.

**If you have added a spike-in control to your sequencing library, please be sure to specify that information on the ticket. Controls for normalization such as "Active Motif" or other antibody spike-ins that are not removed often have poor base-balance/repetitive motifs, and can badly overseed on a flowcell.**

**Tickets and forms for sample submission can be found here.**

Pricing, Support, and Other Details
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For a sequencing pricing list, details on specific services, scheduling, or a quote for services, please email us here. Information about grant support letters can be found here.

Join Email List
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To be added to our email list for news and service updates, please contact us here.

Other Useful Information
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Drop-off locations:
Samples can be left in the labeled fridges at these locations
for 11:00 AM pickup each business day:
Biotech2 outside Suite 207
LRB 6th floor mailroom
ASC8-2058 mailroom
We are also available by appointment if you need to visit with us.
Our shipping address for off-campus customers is
Rose-Gordon Bldg. Rm. 141, 222 Maple Ave, Shrewsbury, MA, 01545.

Helpful Links:

For Illumina Library Building Notes, click here.

Puzzled about Multiplexing and Barcoding? Click here.

There is an updated list of oligo sequences for Illumina library construction. If you are a UMass investigator and wish to obtain a copy, please send an email to and request "the latest Illumina adapter sequences list".

For a letter of support for your grant, click here.

A list of frequently asked questions and answers is here.

The "How Long is THE QUEUE?" FAQ is located here.

We are updating our resources section. If you have a protocol or publication that you found useful, please share. If you have a request for something you think would be beneficial, please email us at

Pricing and Payment Policy
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Please email to get a quote for your desired services.

Processing and analyzing a sample requires time and reagents. Payment for these services is the responsibility of the user submitting the sample and should be rendered in a timely fashion. In the event of a reagent or equipment failure, the samples will be rerun at the next possible opportunity at no additional charge.

Clients withdrawing samples prior to the analysis run will be charged a fee to recover QC assay costs. For the return of archived post-analysis samples, clients will be charged a delivery fee per sample.

Inclement Weather Policy
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In case of extreme and/or inconvenient weather, the machines will still be running but we may not be here for sample login or pickup. Please email us to arrange drop-off if the weather is questionable. The DSCL, MBCL, & PBCE are closed when UMassMed is on "inclement weather alert“.

UMMS PacBio Core logo linking to website

UMMS Molecular Biology Core Labs logo linking to website