Publications - 2014 to 2005

2014

Heyer EE, Ozadam H, Ricci EP, Cenik C and Moore MJ. (2014) An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments. Nucleic Acids Research, December, doi: 10.1093/nar/gku1235.

Carpenter S, Ricci EP, Mercier BC, Moore MJ and Fitzgerald KA. (2014) Post-transcriptional regulation of gene expression in innate immunity. Nature Reviews Immunology, June.

Yang C, Wang H, Qiao T, Yang B, Aliaga L, Qiu L, Tan W, Salameh J, McKenna-Yasek DM, Smith T, Peng L, Moore MJ, Brown Jr. RH, Cai H and Xu Z. (2014) Partial loss of RDP-43 function causes phenotypes of amyotrophic lateral sclerosis. PNAS, March 25.

Chen W and Moore MJ. (2014) The spliceosome: disorder and dynamics defined. Curr Opin Structure Biology. February 11.

Chen W, Shulha HP, Ashar-Patel A, Yan J, Green KM, Query CC, Rhind N, Weng Z and Moore MJ*. (2014) Endogenous U2-U5-U6 snRNA complexes in S. pombe are intron lariat spliceosomes. RNA, Epub Jan 17.

Ricci EP, Kucukural A, Cenik C, Mercier BC, Singh G, Heyer EE, Ashar-Patel A, Peng L and Moore MJ*. (2014) Staufen1 senses overall transcript secondary structure to regulate translation. NSMB, January.

2013

Moore Simas TA, Crawford SL, Bathgate S, Yan J, Robidoux L, Moore MJ and Maynard SE. (2013) Angiogenic biomarkers for prediction of early preeclampsia onset in high-risk women. J Matern Fetal Neonatal Med, October 29.

Shcherbakova I, Gelles J*, Hoskins AA, Friedman L, Serebrov V and Moore MJ*. (2013) Alternative Spliceosome Assembly Pathways Revealed by Single Molecule Fluorescence Microscopy.  Cell Reports, October 17.

Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miler BL, Farese RV Jr, Moore MJ, Shaw CE, Gao FB. (2013). Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One, October 15.

Singh GS, Ricci EP and Moore MJ. (2013) RIPiT-Seq: A high-throughput approach for footprinting RNA:protein complexes. Methods, October 2.

Kucukural A, Ozadam H, Singh G, Moore MJ and Cenik C. (2013) ASPeak: an abundance sensitive peak detection algorithm for RIP-Seq.  Bioinformatics, August.

Carpenter S, Atianand M, Aiello D, Ricci E, Gandhi P, Hall L, Byron M, Monks B, Henry-Bezy M, O'Neill LAJ, Lawrence JB, Moore MJ, Caffrey DR and Fitzgerald KA. (2013) A long noncoding RNA induced by TLRs mediates both activation and repression of immune response genes. Science, August 16.

Li XZ, Roy CK, Moore MJ and Zamore PD. (2013) Defining piRNA primary transcripts. Cell Cycle, June 1.

Jokhi V, Ashley J, Nummari J, Noma A, Ito N, Wakabayashi-Ito N, Moore MJ and Budnik V. (2013). Torsin mediates primary envelopment of large ribonuclear granules at the nuclear envelope.  Cell Reports,April 10.

Maynard SE, Crawford SL, Bathgate S, Yan J, Robidoux L, Moore MJ and Moore TA. (2013) Gestational angiogenic biomarker patterns in high risk preeclampsia groups. AJOG, March 18.

Crawford D, Hoskins AA, Freidman LJ, Gelles J* and Moore MJ*. (2013) Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site.  PNAS USA, April.

Li XZ, Roy CK, Bolcun-Filas E, Xu J, Han B, Moore MJ, Weng Z, Schimenti JC, Zamore PD. (2013) An Ancient Transcription Factor Initiates the Burst of piRNA Production During Meiosis in the Mouse Testis.  Mol Cell, 50; 67-81, April 11.

2012

Bicknell A, Cenik C, and Moore MJ. (2012) Introns in UTRs: Why we should stop ignoring them. BioEssays, 34(12); 1025-34.

Singh GS, Kucukural A, Cenik C, Leszyk JD, Shaffer SA, Weng Z and Moore MJ. (2012) The Cellular EJC Interactome Reveals Higher Order mRNP Structure and an EJC-SR Protein Nexus. Cell, 151(4); 750-764.

Aronin N and Moore MJ. (2012) Hunting Down Huntingtin. NEJM, 367(18); 1753-1754; November.

Wu C, Fallini C, Ticozzi N, Keagle P, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron D, Gonzalez-Perez P, Fox A, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu Z, van den Berg LH, Glass JD, Drory VE, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ, Silani V, Brown RH and Landers JE. (2012) Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature, 48, 499-503, 23 August.

Speese S, Ashley J, Jokhi V, Nunnari J, Barria R, Ataman B, Koon A, Chang Y-T, Li Qian, Moore MJ* and Budnik V* (2012) Nuclear envelope budding enables ribonucleoprotein particle export during synaptic Wnt signaling.  Cell, 149, 832-846, May 11.

Hoskins AA and Moore MJ. (2012) The Spliceosome: A Flexible, Reversible Macromolecular Machine. Trends in Biochemical Sciences, Vol. 37, No. 5, May.

2011

Morello LG, Coltri PP, Quaresma AJC, Simabuco FM, Silva TCL, Singh G, Nickerson JA, Oliveira CC, Moore MJ and Zanchin NIT. (2011) The Human Nucleolar Protein FTSJ3 Associates with NIP7 and Functions in Pre-rRNA Processing. PLoS ONE, 2011 Dec 16; 6(12); e29174.

Hoskins AA, Gelles J, Moore MJ. (2011) New insights into the spliceosome by single molecule fluorescence microscopy. Curr Opin Chem Biol. Nov 4.

Cenik C, Chua HN, Zhang H, Tarnawsky S, Akef A, Derti A, Tasan, Moore MJ, Palazzo AF and Roth FP. (2011) Genome Analysis Reveals Interplay between 5’UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes. PLoS Genetics, 2011 Apr;7(4):e1001366.

Hoskins AA, Freidman LJ, Gallagher SS, Crawford DJ, Anderson EG, Wombacher R, Ramirez N, Cornish VW, Gelles J, and Moore MJ. (2011) Ordered and Dynamic Assembly of Single Spliceosomes. Science, 331: 1289-1295.

2010

Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz, J, Peng J, Moore MJ, and Yu G. (2010) Identification of neuronal RNA targets of TDP-43-containing Ribonucleoprotein complexes. J Biol Chem, 286:1204-15. Epub 2010 Nov 4.

Moore MJ and Flotte TR. (2010) Autoimmunity in a Genetic Disease – A Cautionary Tale. NEJM, 363; 15.

Lemmens R, Moore MJ, Al-Chalabi A, Brown RH Jr, Robberecht W (2010) RNA metabolism and the pathogenesis of motor neuron diseases. Trends Neuroscience, May.

2009

Albert B, McPherson P, O’Brien K, Czaicki N, DeStefino V, Osman S, Li M, Day B, Grabowski P, Moore MJ, Vogt A and Koide K (2009). Meayamycin Inhibits pre-mRNA Splicing and Exhibits Picomolar Activity Against Multidrug Resistant Cells. Molecular Cancer Therapeutics8(8): 2308-2318, August.

Cole SE, LaRiviere FJ, Merrikh C and Moore MJ (2009). A Convergence of rRNA and mRNA Quality Control Pathways Revealed by Mechanistic Analysis of Nonfunctional rRNA Decay. Molecular Cell 34: 440-450, May 29.

Moore MJ and Proudfoot NJ. (2009). Pre-mRNA Processing Reaches Back to Transcription and Ahead to Translation. Cell 136: 688-700, February 20.

2008

Bramham CR, Worley PF, Moore MJ and Guzowski JF. (2008) The Immediate Early Gene Arc/Arg3/1: Regulation, Mechanisms, and Function. The Journal of Neuroscience 28(46): 11760-11767, November 12.

Rozovsky N, Butterworth AC and Moore MJ. (2008) Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. RNA 14: 2136-2148.

O’Brien K, Matlin AJ, Lowell AM, and Moore MJ (2008). The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing. J Biol Chem Vol. 283(48), No. 58, 33147-33154, November 28.

Crawford DJ, Hoskins AA, Friedman LJ, Gelles J and Moore MJ. (2008) Visualizing the splicing of single pre-mRNA molecules in whole cell extract. RNA 14: 170-179.

2007

Giorgi C, Yeo GW, Stone ME, Katz DB, Berge C, Turrigiano G and Moore MJ. (2007) The EJC Factor elF4All Modulates Synaptic Strength and Neuronal Protein Expression. Cell 130: 179-191, July 13.

Matlin AJ and Moore MJ. (2007) Spliceosome Assembly and Composition. In Alternative Splicing in the Postgenomic Era (Blencowe BJ and Graveley B, Eds.) Landes Bioscience and Springer Science+Business Media, Chapter 2, pp. 14-35.

Giorgi C and Moore MJ. (2007) The nuclear nurture and cytoplasmic nature of localized mRNPs. Seminars in Cell & Developmental Biology 18: 186-193.

2006

LaRiviere FJ, Cole SE, Ferullo DJ and Moore MJ. (2006) A Late-Acting Quality Control Process for Mature Eukaryotic rRNAs. Molecular Cell 24: 619-626, November 17.

Stroupe ME, Tange TØ, Thomas D, Moore MJ and Grigorieff N. (2006) The three dimensional architecture of the EJC core. Journal of Molecular Biology 360: 743-749.

Shibuya T, Tange TØ, Stroupe ME and Moore MJ. (2006) Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. RNA 12: 360-374.

2005

Tange TØ, Shibuya T, Jurica MS and Moore MJ. (2005) Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA 11:1869-1883.

Moore, MJ. (2005) From birth to death:  The complex lives of eukaryotic mRNAs. Science 309:1514-8151.

Schroder PA and Moore MJ. (2005) Association of ribosomal proteins with nascent transcripts in S. cerevisiae. RNA 11: 1521-1529.