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Haynes Lab Publications

Pires J, Haynes CM (2018). Mitochondrial biogenesis: MitoCPR resuscitates import-defective mitochondria. Current Biology. Jun 4;28(11): 669-671. 

Kumar A, Katz LS, Schulz AM, Kim M, Honig LB, Li L, Davenport B, Homann D, Garcia-Ocana A, Herman MA, Haynes CM, Chipuk JE, Scott (2018) Activation of Nrf2 is required for Normal and ChREBPa-augmented glucose-stimulated b cell proliferation. Diabetes. In press

Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M (2018) Multiple molecular mechanisms rescue mtDNA disease in C. elegans. Cell Reports. Mar 20;22(12):3115-3125

Melber A, Haynes CM (2018) UPRmt regulation and output: a stress response mediated mitochondrial-nuclear communication. Cell Research. Mar;28(3):281-295. 

Shpilka T, Haynes CM. (2018) The mitochondrial UPR: Mechanism, physiologic functions and implications in aging. Nature Reviews Molecular Cell Biology. Feb 19(2):109-120. 

Lamech L, Haynes CM. (2017) Mitochondrial sterol oxidation marks the spot. Molecular Cell. Nov 16;68(4):641-642. 

Lamech L, Haynes CM. (2017) Vms1 relieves a mitochondrial import chokehold. Developmental Cell. Nov 6;43(3):259-260.

 Deng P, Haynes CM. (2017) Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR. Seminars in Cancer Biology. In press.

 Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. (2017) Mitochondrial stress restores the heat shock response and prevents proteostasis collapse during aging. Cell Reports. Nov 7;21:1481-1494.

 Qureshi MA, Haynes CM, Pellegrino MW. (2017) The mitochondrial unfolded protein response: signaling from the powerhouse. Journal of Biological Chemistry. Aug 18;292(33):13500-13506.

 Fiorese CJ, Haynes CM. (2017) Integrating the UPRmt into the mitochondrial maintenance network. Crit Rev Biochem Mol Biol. June:52(3): 304-313.

 Deng P, Haynes CM. (2016) The mitokine quest(ion). Cell Research. Dec:26(12): 1265-1266.

 Fiorese CJ*, Schulz AM*, Lin YF, Rosin N, Pellegrino MW, Haynes CM. (2016) The transcription factor ATF5 mediates a mammalian mitochondrial UPR. Current Biology. Aug 8:26(15): 2037-43.

Lin YF, Schulz AM, Pellegrino MW, Lu Y, Shaham S, Haynes CM. (2016) Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Nature. May 2:533(7603): 416-419.

Lin YF, Haynes CM. (2016) Metabolism and the UPRmt. Molecular Cell. Mar 3:61(5): 677-682.

Reddy KC, Dunbar TL, Nargund AN, Haynes CM, Troemel ER. (2016) The C. elegans CCAAT-enhancer binding protein gamma is required for surveillance immunity. Cell Reports. Feb 23:14(7): 1581-1589.

Haynes CM. (2015) Surviving import failure. Nature. Aug 27:524(7566): 419-420.

Lamech, LT, Haynes CM. (2015) The unpredictability of prolonged activation of stress response pathways. Journal of Cell Biology. June 22:209(6): 781-87.

Schulz AM, Haynes CM. (2015) UPRmt-mediated cytoprotection and organismal aging. BBA-Bioenergetics. April 7. pii: S0005-2728(15)00058-4. doi: 10.1016/j.bbabio.2015.03.008.

Nargund AN, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM. (2015) Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPRmt. Molecular Cell. April 2;58(1):123-33.

Pellegrino MW, Haynes CM. (2015) Mitophagy and the UPRmt in neurodegeneration and bacterial infection. BMC Biology. April 3;13(1): 22. doi: 10.1186/s12915-015-0129-1.

Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D. (2015) A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoetic stem cell aging. Science. March 20;347(6228): 1374-1377.

Pellegrino MW, Nargund AN, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM. (2014) Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. Dec 18;516(7531): 414-417.

Haynes CM, Fiorese CJ, Lin YF.(2013) Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded protein response and beyond. Trends in Cell Biology. July;23(7): 311-318.

Nargund AN*, Pellegrino MW*, Fiorese CJ, Baker BM, Haynes CM. (2012) Mitochondrial import of ATFS-1 regulates mitochondrial UPR activation. Science. Aug 3;337(6094): 587-90.

Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS. (2013) Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel. Biochim Biophys Acta. May;1827(5): 598-611.

Baker BM, Nargund AN, Sun T, Haynes CM. (2012) Protective coupling of mitochondrial function and protein synthesis via the eIF2a kinase GCN-2. PLoS Genetics. Jun;8(6): e1002760.

Pellegrino MW, Nargund AN, Haynes CM. (2013) Signaling the mitochondrial unfolded protein response. Biochim Biophys Acta-Mol Cell Res. Feb;1833(2); 410-16.

Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M. (2011) Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nature Cell Biology Oct 16;13(11): 1335-43.

Baker BM, Haynes CM. (2011) Mitochondrial Protein Quality Control: Biogenesis and Old Age. Trends in Biochemical Sciences. May; 36(5): 254-61.

Haynes CM*, Ron D. (2010) The mitochondrial UPR: protecting organelle protein homeostasis. The Journal of Cell Science. Nov 15;123: 3849-55. *corresponding author

Haynes CM*, Yang Y, Blais S, Neubert TA, Ron D*. (2010) The matrix peptide exporter HAF‑1 signals a mitochondrial UPR by activating the bZip transcription factor ZC376.7 in C. elegans. Molecular Cell. Feb 26;37(4): 529-40. *corresponding author

Wiseman RL, Haynes CM, Ron D. (2010) Snapshot: The unfolded protein response. Cell. Feb 19;140(4): 590.

Wiseman RL, Zhang Y, Lee, KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. (2010) Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. Apr 23;38(2): 291-304.

Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu C, Roguev A, Krogan NJ, Neubert TA, Ron D. (2009) Thioredoxin-related protein is an arsenite-regulated thiol reductase of the proteasome 19S particle. Journal of Biological Chemistry. May 29;284(22): 15233-45.

Yun C, Stanhill A, Yang Y, Haynes CM, Xu CF, Neubert TA, Mor A, Philips MR, Ron D. (2008) Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proc Natl Acad Sci USA. May 13;105(19): 7094-9.

Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D. (2007) ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Developmental Cell. Oct;13(1): 1-14.

Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong XP, Ron D. (2006). An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Molecular Cell. Sept 15;23(6): 875-885.

Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D. (2006) Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics. Sept;174(1): 229-239.

Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, Lindquist S. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson’s models. Science. July;313(5785): 324-328.

Haynes CM, Titus EA, Cooper AA. (2004) Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Molecular Cell. Sept 10;15(5): 767-76.

Haynes CM, Caldwell S, Cooper AA. (2002) An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. Journal of Cell Biology. July 8;158(1): 91-101.