Structural and Mechanistic Studies of Macromolecular Machines
We use a combination of biochemistry, biophysics and structural methods to elucidate how these vitally important protein complexes are integrated into cellular pathways.Meet the Lab
The Kelch lab is interested in determining how macromolecular machines work, with special emphasis on machines involved in DNA replication and repair. Understanding how these machines work will not only illuminate the underpinnings of these critically important cellular pathways, but can also lead to new targets for the development of novel cancer therapeutics and antibiotics.Read More
Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T.
Nucleic Acids Res. 2019 May 22. pii: gkz441. doi: 10.1093/nar/gkz441. [Epub ahead of print]