Page Menu

Structural and Mechanistic Studies of Macromolecular Machines

The Lab


Uncovering the Principles of Molecular Machinery at the Atomic Level

We use a combination of biochemistry, biophysics and structural methods to elucidate how these vitally important protein complexes are integrated into cellular pathways.

Meet the Lab

Research Focus


Structure and Mechanism of Large Macromolecular Complexes

The Kelch lab is interested in determining how macromolecular machines work, with special emphasis on machines involved in DNA replication and repair.  Understanding how these machines work will not only illuminate the underpinnings of these critically important cellular pathways, but can also lead to new targets for the development of novel cancer therapeutics and antibiotics.

Read More



Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T.
Nucleic Acids Res. 2019 May 22. pii: gkz441. doi: 10.1093/nar/gkz441. [Epub ahead of print]

All Publications


Follow our research, stay in touch – join the lab! 

Contact Us

Lazare Research Building 923
Campus Map (pdf)

508-856-8322 (office)
508-856-6868 (Lab)


Mailing Address:
University of Massachusetts Medical School
Attn: Dr. Brian Kelch/BMP department
364 Plantation St LRB923
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

Read more here

Undergraduates interested in pursuing a PhD at UMass Medical School should apply directly to the Graduate School of Biomedical Sciences Program.

Additional Resources
click to open search panel