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Structural and Mechanistic Studies of Macromolecular Machines

The Lab


Uncovering the Principles of Molecular Machinery at the Atomic Level

We take multi-disciplinary approaches to elucidate how vitally important protein machines are integrated into cellular pathways. We value diversity in science, both in terms of scientific approaches and the scientists who perform the studies. 

Meet the Lab

Research Focus


Structure and Mechanism of Large Macromolecular Complexes

The Kelch lab is interested in determining how macromolecular machines work, with special emphasis on machines involved in virus assembly and in DNA replication & repair.  Understanding how these machines work will not only illuminate the underpinnings of these critically important cellular pathways, but can also lead to new targets for the development of novel cancer therapeutics, antivirals and antibiotics.

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Contact Us

Lazare Research Building 923
Campus Map (pdf)

508-856-8322 (office)
508-856-6868 (Lab)


Mailing Address:
UMass Chan Medical School
Attn: Dr. Brian Kelch/BMB Department
364 Plantation St LRB923
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

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Undergraduates interested in pursuing a PhD at UMass Chan Medical School should apply directly to the Morningside Graduate School of Biomedical Sciences Program.