Structural and Mechanistic Studies of Macromolecular Machines

Research Focus

Kelch Lab

Structure and Mechanism of Large Macromolecular Complexes

The Kelch lab is interested in determining how macromolecular machines work, with special emphasis on machines involved in DNA replication and repair.  Understanding how these machines work will not only illuminate the underpinnings of these critically important cellular pathways, but can also lead to new targets for the development of novel cancer therapeutics and antibiotics.

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The Lab

Kelch LabUncovering the Principles of Molecular Machinery at the Atomic Level

We use a combination of biochemistry, biophysics and structural methods to elucidate how these vitally important protein complexes are integrated into cellular pathways.

Meet the Lab

 

 

Publications

Kobertz Publications

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.

 

Author(s): Hilbert BJ, Hayes JA, Stone NP, Xu RG, Kelch BA 

 

All Publications

 

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Contact Us

Office:
Lazare Research Building 923
Campus Map (pdf)

Phone:
508-856-8322 (office)
508-856-6868 (Lab)

Email:
Brian.Kelch@umassmed.edu

Mailing Address:
University of Massachusetts Medical School
Attn: Dr. Brian Kelch/BMP department
364 Plantation St LRB923
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

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Undergraduates interested in pursuing a PhD at UMass Medical School should apply directly to the Graduate School of Biomedical Sciences Program.