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Katherine Fitzgerald, PhD
Division Chief

Research Focus: Understanding molecular mechanisms controlling inflammatory response

  • Sensing and signaling in innate immunity (TLRs, Inflammasomes, cGAS/STING)
  • Autoinflammatory diseases (e.g., SAVI - STING associated Vasculopathy with onset in Infancy)
  • Therapeutic targeting of Inflammasomes and cGAS/STING Signaling

Lisa Cavacini, PhD

Research Focus: Immunoregulation of infectious disease, cancer and autoimmune disease

  • Oral prophylaxis to prevent and treat enteric infections and gastrointestinal disorders
  • B cell regulation in autoimmunity and infectious disease
  • Epitope discovery to diagnose, prevent or treat infectious disease and cancer
 Kathleen Engelman

Kathleen Engelman, PhD

Research Focus: 

  • Antibody engineering and therapeutic protein design
  • Drug delivery across the blood-brain barrier for treatment of Alzheimer’s Disease
  • Antibody-drug conjugates as potential anti-viral agents
 Stefania Gallucci, MD

Stefania Gallucci, MD

Research Focus: Innate immunity responses in host defense and autoimmunity

  • Biology of dendritic cell activation and regulation through the immunometabolism
  • Dendritic cell recognition of DAMPs and PAMPs
  • Role of innate immunity in the pathogenesis of autoimmunity
  • Innate immune responses to bacterial infections and biofilms
  • Novel therapeutic targets in lupus autoimmunity

Fiachra Humphries, PhD

Research Focus: How immunometabolism regulates infectious disease and inflammation

  • Regulation of cell death by oncometabolites
  • Macrophage receptor biology in tumorigenesis and metastasis
  • Mitochondrial reprogramming in "inflamm-aging"
  • Metabolic control of viral infections
  • Therapeutic targeting of innate immune signaling pathways

Diogo Magnani, PhD

Research Focus: Developing translatable immunologic therapeutic agents

  • Translation of human biologics in animal models (e.g., the study of species-specific biology of Immunoglobulins, Fc Receptors, etc.)
  • Development of species-tailored immunomodulatory reagents
  • Genetic delivery of immunobiological therapies