Our lab is focused on understanding the molecular mechanisms controlling the inflammatory response. We are interested in determining how the immune system discriminates between pathogens, resident microflora and host molecules to both protect the host from infection and avoid damaging inflammatory diseases. We employ multifaceted approaches including immunology, biochemistry, molecular biology and genetics to understand these mechanisms. Our long-term goals are to understand how dysregulation of innate immunity underlies the pathogenesis of infectious, inflammatory and autoimmune disease in humans.
The Fitzgerald lab is part of the Program In Innate Immunity (PII) an interdisciplinary and interdepartmental group of investigators, who are focused on discovering the underlying mechanisms that drive immune defenses and inflammation, in both health and disease.