Horae Gene Therapy Center Faculty
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Terence Flotte, MD
Academic Role: Dean T.H. Chan School of Medicine, Provost and Executive Deputy Chancellor, Professor, Pediatrics
Focus: Recombinant adeno-associated virus (AAV) gene therapy vectors for, cystic fibrosis (CF), alpha-1-antitrypsin deficiency (AAT) and fatty oxidation disorders (FAO).
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Guangping Gao, PhD
Academic Role: Professor Department of Microbiology and Physiological Systems, Director Li Weibo Institute for Rare Diseases Research, Director Gene Therapy Center & Vector Core, Scientific Director UMMS-China Translational Research Initiatives
Focus: Adeno-associated virus vector mediated gene transfer for gene therapy & gene therapy of inherited neurodegenerative Canavan Disease.
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Heather Gray-Edwards, DVM, PhD
Academic Role: Assistant Professor, Department of Radiology
Focus: Development of MRI-based methods to examine disease progression of neurodegenerative disorders. Evaluating effectiveness of adeno-associated virus (AAV)-mediated gene therapy.
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Alisha Gruntman, DVM, PhD, DACVIM
Academic Role: Assistant Professor, Department of Pediatrics
Focus: Gene therapy and neuromodulation for respiratory insufficiency in genetic diseases. Respiratory physiology and neurophysiology core.
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Allison Keeler, PhD
Academic Role: Assistant Professor, Department of Pediatrics
Focus: Gene therapy and cell engineering for single gene disorders and novel immunotherapeutics
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Miguel Sena-Esteves, PhD
Academic Role: Associate Professor, Department of Neurology
Focus: Gene therapy approaches for the treatment of neurodegenerative lysosomal storage diseases such as GM1-gangliosidosis and GM2-gangliosidoses (Tay-Sachs and Sandhoff diseases).
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Phil Tai, PhD
Academic Role: Assistant Professor, Department of Microbiology and Physiological Systems
Focus: Development of next-gen sequencing methodologies to profile AAV vector genome quality, and discovery and characterization of natural AAV capsid isolates for vectorization and gene therapy.
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Dan Wang, PhD
Academic Role: Assistant Professor, RNA Therapeutics Institute
Focus: AAV-mediated RNA therapeutics and gene editing therapeutics; AAV biology; Gene therapy for rare diseases; Animal modeling.
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Jun Xie, PhD
Academic Role: Research Assistant Professor, Department of Microbiology and Physiological Systems
Focus: AAV vector technology and AAV-mediated miRNA therapeutics.
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Guocai Zhong, PhD
Academic Role: Assistant Professor, RNA Therapeutics Institute
Focus: RNA switch engineering and regulatable gene therapy development for fatal genetic disease, metabolic disorders, and infectious diseases.
