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Publications
Total:
displaying 10 out of
100
results
Triggered Release of Ampicillin from Metallic Implant Coatings for Combating Periprosthetic Infections
Wednesday, May 01, 2024
Author(s):
Feiyang Chen,Jordan D Skelly,Shing-Yun Chang,Jie Song
Expanding the Potential of Neoantigen Vaccines: Harnessing Bacille Calmette-Guérin Cell-Wall-Based Nanoscale Adjuvants for Enhanced Cancer Immunotherapy
Monday, April 29, 2024
Author(s):
Kangkang Liu,Jing Peng,Yunfei Guo,Yiming Li,Xiang Qi,Dengyi Duan,Taipeng Li,Jianmin Li,Yuanjie Niu,Gang Han,Yang Zhao
Muscle-Specific Pyruvate Kinase Isoforms, Pkm1 and Pkm2, Regulate Mammalian SWI/SNF Proteins and Histone 3 Phosphorylation During Myoblast Differentiation
Monday, April 22, 2024
Author(s):
Monserrat Olea-Flores,Tapan Sharma,Odette Verdejo-Torres,Imaru DiBartolomeo,Paul R Thompson,Teresita Padilla-Benavides,Anthony N Imbalzano
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo
Saturday, April 13, 2024
Author(s):
Samantha L Sarli,Hassan H Fakih,Karen Kelly,Gitali Devi,Julia M Rembetsy-Brown,Holly R McEachern,Chantal M Ferguson,Dimas Echeverria,Jonathan Lee,Jacquelyn Sousa,Hanadi F Sleiman,Anastasia Khvorova,Jonathan K Watts
More than 185 CAG repeats: a point of no return in Huntington's disease biology
Monday, April 08, 2024
Author(s):
Jillian Belgrad,Anastasia Khvorova
Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
Thursday, April 04, 2024
Author(s):
Alok K Mishra,Tianyi Ye,Shahid Banday,Ritesh P Thakare,Chinh Tran-To Su,Ngoc N H Pham,Amjad Ali,Ankur Kulshreshtha,Shreya Roy Chowdhury,Tessa M Simone,Kai Hu,Lihua Julie Zhu,Birgit Eisenhaber,Sara K Deibler,Karl Simin,Paul R Thompson,Michelle A Kelliher,Frank Eisenhaber,Sunil K Malonia,Michael R Green
RNAi-based drug design: considerations and future directions
Wednesday, April 03, 2024
Author(s):
Qi Tang,Anastasia Khvorova
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Tuesday, April 02, 2024
Author(s):
Kyounghee Min,Batuhan Yenilmez,Mark Kelly,Dimas Echeverria,Michael Elleby,Lawrence M Lifshitz,Naideline Raymond,Emmanouela Tsagkaraki,Shauna M Harney,Chloe DiMarzio,Hui Wang,Nicholas McHugh,Brianna Bramato,Brett Morrison,Jeffery D Rothstein,Anastasia Khvorova,Michael P Czech
Calcineurin promotes adaptation to chronic stress through two distinct mechanisms
Tuesday, April 02, 2024
Author(s):
Mackenzie J Flynn,Nicholas W Harper,Rui Li,Lihua Julie Zhu,Michael J Lee,Jennifer A Benanti
Triplet-triplet annihilation photon upconversion-mediated photochemical reactions
Friday, March 22, 2024
Author(s):
Ling Huang,Gang Han
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
Thursday, March 21, 2024
Author(s):
Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J Keagle,Justin A McDonough,Sivakumar Boopathy,Miguel Sena-Esteves,Jeffrey A Nickerson,Cathleen Lutz,William C Skarnes,Elaine T Lim,Dorothy P Schafer,Francesca Massi,John E Landers,Daryl A Bosco
Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation
Wednesday, March 20, 2024
Author(s):
Jillian Belgrad,Hassan H Fakih,Anastasia Khvorova
Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon
Tuesday, March 19, 2024
Author(s):
David Teran,Ying Zhang,Andrei A Korostelev
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication
Friday, March 15, 2024
Author(s):
Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch
Functional genomic screens with death rate analyses reveal mechanisms of drug action
Thursday, March 14, 2024
Author(s):
Megan E Honeywell,Marie S Isidor,Nicholas W Harper,Rachel E Fontana,Gavin A Birdsall,Peter Cruz-Gordillo,Sydney A Porto,Madison Jerome,Cameron S Fraser,Kristopher A Sarosiek,David A Guertin,Jessica B Spinelli,Michael J Lee
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance
Tuesday, March 12, 2024
Author(s):
Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons
Thursday, March 07, 2024
Author(s):
Minggang Fang,Sara K Deibler,Pranathi Meda Krishnamurthy,Feng Wang,Paola Rodriguez,Shahid Banday,Ching-Man Virbasius,Miguel Sena-Esteves,Jonathan K Watts,Michael R Green
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope
Saturday, February 17, 2024
Author(s):
Nathan Bamidele,Han Zhang,Xiaolong Dong,Haoyang Cheng,Nicholas Gaston,Hailey Feinzig,Hanbing Cao,Karen Kelly,Jonathan K Watts,Jun Xie,Guangping Gao,Erik J Sontheimer
Harmonizing the Generation and Pre-publication Stewardship of FAIR Image data
Wednesday, February 14, 2024
Author(s):
Nikki Bialy,Frank Alber,Brenda Andrews,Michael Angelo,Brian Beliveau,Lacramioara Bintu,Alistair Boettiger,Ulrike Boehm,Claire M Brown,Mahmoud Bukar Maina,James J Chambers,Beth A Cimini,Kevin Eliceiri,Rachel Errington,Orestis Faklaris,Nathalie Gaudreault,Ronald N Germain,Wojtek Goscinski,David Grunwald,Michael Halter,Dorit Hanein,John W Hickey,Judith Lacoste,Alex Laude,Emma Lundberg,Jian Ma,Leonel Malacrida,Josh Moore,Glyn Nelson,Elizabeth Kathleen Neumann,Roland Nitschke,Shuichi Onami,Jaime A Pimentel,Anne L Plant,Andrea J Radtke,Bikash Sabata,Denis Schapiro,Johannes Schöneberg,Jeffrey M Spraggins,Damir Sudar,Wouter-Michiel Adrien Maria Vierdag,Niels Volkmann,Carolina Wählby,Siyuan Steven Wang,Ziv Yaniv,Caterina Strambio-De-Castillia
Multispecies-targeting siRNAs for the modulation of JAK1 in the skin
Friday, February 02, 2024
Author(s):
Qi Tang,Katherine Y Gross,Hassan H Fakih,Samuel O Jackson,Mohammad Zain U I Abideen,Kathryn R Monopoli,Carine Blanchard,Claire Bouix-Peter,Thibaud Portal,John E Harris,Anastasia Khvorova,Julia F Alterman
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors
Tuesday, January 09, 2024
Author(s):
Shun-Yun Cheng,Jillian Caiazzi,Annabelle Biscans,Julia F Alterman,Dimas Echeverria,Nicholas McHugh,Matthew Hassler,Samson Jolly,Delaney Giguere,Joris Cipi,Anastasia Khvorova,Claudio Punzo
A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system
Monday, January 08, 2024
Author(s):
Jillian Belgrad,Qi Tang,Sam Hildebrand,Ashley Summers,Ellen Sapp,Dimas Echeverria,Dan O'Reilly,Eric Luu,Brianna Bramato,Sarah Allen,David Cooper,Julia Alterman,Ken Yamada,Neil Aronin,Marian DiFiglia,Anastasia Khvorova
Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury
Thursday, December 21, 2023
Author(s):
Elif O Dogan,James Bouley,Jianjun Zhong,Ashley L Harkins,Allison M Keeler,Daryl A Bosco,Robert H Brown,Nils Henninger
Glucose stress causes mRNA retention in nuclear Nab2 condensates
Tuesday, December 19, 2023
Author(s):
Stephanie Heinrich,Maria Hondele,Désirée Marchand,Carina Patrizia Derrer,Mostafa Zedan,Alexandra Oswald,Liliana Malinovska,Federico Uliana,Sarah Khawaja,Roberta Mancini,David Grunwald,Karsten Weis
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors
Monday, December 18, 2023
Author(s):
Zexiang Chen,Suet-Yan Kwan,Aamir Mir,Max Hazeltine,Minwook Shin,Shun-Qing Liang,Io Long Chan,Karen Kelly,Krishna S Ghanta,Nicholas Gaston,Yueying Cao,Jun Xie,Guangping Gao,Wen Xue,Erik J Sontheimer,Jonathan K Watts
Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity
Wednesday, December 13, 2023
Author(s):
Hassan H Fakih,Qi Tang,Ashley Summers,Minwook Shin,Julianna E Buchwald,Rosemary Gagnon,Vignesh N Hariharan,Dimas Echeverria,David A Cooper,Jonathan K Watts,Anastasia Khvorova,Hanadi F Sleiman
Differences in clamp loader mechanism between bacteria and eukaryotes
Monday, December 11, 2023
Author(s):
Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch
Nano-optogenetic CAR-T Cell Immunotherapy
Saturday, December 09, 2023
Author(s):
Nhung Thi Nguyen,Siyao Liu,Gang Han,Yubin Zhou,Kai Huang
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo
Thursday, November 30, 2023
Author(s):
Han Zhang,Karen Kelly,Jonathan Lee,Dimas Echeverria,David Cooper,Rebecca Panwala,Nadia Amrani,Zexiang Chen,Nicholas Gaston,Atish Wagh,Gregory A Newby,Jun Xie,David R Liu,Guangping Gao,Scot A Wolfe,Anastasia Khvorova,Jonathan K Watts,Erik J Sontheimer
Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy
Monday, November 27, 2023
Author(s):
Sarah Engelbeen,Daniel O'Reilly,Davy Van De Vijver,Ingrid Verhaart,Maaike van Putten,Vignesh Hariharan,Matthew Hassler,Anastasia Khvorova,Masad J Damha,Annemieke Aartsma-Rus
Quick tips for interpreting cell death experiments
Tuesday, November 21, 2023
Author(s):
Scott J Dixon,Michael J Lee
A nematode model to evaluate microdeletion phenotype expression
Monday, November 13, 2023
Author(s):
Katianna R Antkowiak,Peren Coskun,Sharon T Noronha,Davide Tavella,Francesca Massi,Sean P Ryder
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Sunday, November 05, 2023
Author(s):
Qi Tang,Hassan H Fakih,Mohammad Zain Ui Abideen,Samuel R Hildebrand,Khashayar Afshari,Katherine Y Gross,Jacquelyn Sousa,Allison S Maebius,Christina Bartholdy,Pia Pernille Søgaard,Malene Jackerott,Vignesh Hariharan,Ashley Summers,Xueli Fan,Ken Okamura,Kathryn R Monopoli,David A Cooper,Dimas Echeverria,Brianna Bramato,Nicholas McHugh,Raymond C Furgal,Karen Dresser,Sarah J Winter,Annabelle Biscans,Jane Chuprin,Nazgol-Sadat Haddadi,Shany Sherman,Ümmügülsüm Yıldız-Altay,Mehdi Rashighi,Jillian M Richmond,Claire Bouix-Peter,Carine Blanchard,Adam Clauss,Julia F Alterman,Anastasia Khvorova,John E Harris
Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model
Friday, November 03, 2023
Author(s):
Hector Ribeiro Benatti,Rachel D Prestigiacomo,Toloo Taghian,Rachael Miller,Robert King,Matthew J Gounis,Ugur Celik,Stephanie Bertrand,Susan Tuominen,Lindsey Bierfeldt,Elizabeth Parsley,Jillian Gallagher,Erin F Hall,Abigail W McElroy,Miguel Sena-Esteves,Anastasia Khvorova,Neil Aronin,Heather L Gray-Edwards
Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy
Tuesday, October 24, 2023
Author(s):
Ozen Leylek,Megan E Honeywell,Michael J Lee,Michael T Hemann,Gulnihal Ozcan
Surface modification of neurovascular stents: from bench to patient
Wednesday, October 04, 2023
Author(s):
Christopher T Zoppo,J Mocco,Nathan W Manning,Alexei A Bogdanov,Matthew J Gounis
Protein citrullination: inhibition, identification and insertion
Sunday, October 01, 2023
Author(s):
Leonard Barasa,Paul R Thompson
A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels
Sunday, September 24, 2023
Author(s):
Janneke Doedée Icso,Paul Ryan Thompson
Community-developed checklists for publishing images and image analyses
Thursday, September 14, 2023
Author(s):
Christopher Schmied,Michael S Nelson,Sergiy Avilov,Gert-Jan Bakker,Cristina Bertocchi,Johanna Bischof,Ulrike Boehm,Jan Brocher,Mariana T Carvalho,Catalin Chiritescu,Jana Christopher,Beth A Cimini,Eduardo Conde-Sousa,Michael Ebner,Rupert Ecker,Kevin Eliceiri,Julia Fernandez-Rodriguez,Nathalie Gaudreault,Laurent Gelman,David Grunwald,Tingting Gu,Nadia Halidi,Mathias Hammer,Matthew Hartley,Marie Held,Florian Jug,Varun Kapoor,Ayse Aslihan Koksoy,Judith Lacoste,Sylvia Le Dévédec,Sylvie Le Guyader,Penghuan Liu,Gabriel G Martins,Aastha Mathur,Kota Miura,Paula Montero Llopis,Roland Nitschke,Alison North,Adam C Parslow,Alex Payne-Dwyer,Laure Plantard,Rizwan Ali,Britta Schroth-Diez,Lucas Schütz,Ryan T Scott,Arne Seitz,Olaf Selchow,Ved P Sharma,Martin Spitaler,Sathya Srinivasan,Caterina Strambio-De-Castillia,Douglas Taatjes,Christian Tischer,Helena Klara Jambor
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates
Thursday, September 14, 2023
Author(s):
Bin Liu,Xiaolong Dong,Chunwei Zheng,David Keener,Zexiang Chen,Haoyang Cheng,Jonathan K Watts,Wen Xue,Erik J Sontheimer
Development of LB244, an Irreversible STING Antagonist
Monday, September 11, 2023
Author(s):
Leonard Barasa,Sauradip Chaudhuri,Jeffrey Y Zhou,Zhaozhao Jiang,Shruti Choudhary,Robert Madison Green,Elenore Wiggin,Michael Cameron,Fiachra Humphries,Katherine A Fitzgerald,Paul R Thompson
Targeting STING oligomerization with small-molecule inhibitors
Monday, August 07, 2023
Author(s):
Fiachra Humphries,Liraz Shmuel-Galia,Zhaozhao Jiang,Jeffrey Y Zhou,Leonard Barasa,Santanu Mondal,Ruth Wilson,Nadia Sultana,Scott A Shaffer,Sze-Ling Ng,G Scott Pesiridis,Paul R Thompson,Katherine A Fitzgerald
Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice
Tuesday, August 01, 2023
Author(s):
Aydan Kahriman,James Bouley,Idil Tuncali,Elif O Dogan,Mariana Pereira,Thuyvan Luu,Daryl A Bosco,Samer Jaber,Owen M Peters,Robert H Brown,Nils Henninger
Modulating On-Demand Release of Vancomycin from Implant Coatings via Chemical Modification of a Micrococcal Nuclease-Sensitive Oligonucleotide Linker
Monday, July 31, 2023
Author(s):
Jordan D Skelly,Feiyang Chen,Shing-Yun Chang,Rewati R Ujjwal,Ananta Ghimire,David C Ayers,Jie Song
Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice
Tuesday, July 18, 2023
Author(s):
Batuhan Yenilmez,Shauna Harney,Chloe DiMarzio,Mark Kelly,Kyounghee Min,Dimas Echeverria,Brianna M Bramato,Samuel O Jackson,Keith Reddig,Jason K Kim,Anastasia Khvorova,Michael P Czech
Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy
Monday, July 17, 2023
Author(s):
Kathryn R Monopoli,Dmitry Korkin,Anastasia Khvorova
FruitFire: a luciferase based on a fruit fly metabolic enzyme
Monday, July 10, 2023
Author(s):
Spencer T Adams,Jacqueto Zephyr,Markus F Bohn,Celia A Schiffer,Stephen C Miller
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
Monday, July 03, 2023
Author(s):
Vignesh Narayan Hariharan,Jillian Caiazzi,Rachael Miller,Chantal Ferguson,Ellen Sapp,Hassan Fakih,Qi Tang,Nozomi Yamada,Raymond Furgal,Joseph Paquette,Brianna Bramato,Nicholas McHugh,Ashley Summers,Clemens Lochmann,Bruno Godinho,Samuel Hildebrand,Dimas Echeverria,Matthew Hassler,Julia Alterman,Marian DiFiglia,Neil Aronin,Anastasia Khvorova,Ken Yamada
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease
Friday, June 30, 2023
Author(s):
Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP
Monday, June 26, 2023
Author(s):
Sneha Shah,Kevin J Sharp,Sithara Raju Ponny,Jonathan Lee,Jonathan K Watts,Elizabeth Berry-Kravis,Joel D Richter
Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases
Tuesday, June 20, 2023
Author(s):
Innus Mohammad,Kate L Liebmann,Stephen C Miller
SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism
Monday, June 12, 2023
Author(s):
Janneke D Icso,Leonard Barasa,Paul R Thompson
siRNAs-A New Class of Medicines
Monday, June 12, 2023
Author(s):
Anastasia Khvorova
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
Friday, June 09, 2023
Author(s):
Ken Yamada,Vignesh Narayan Hariharan,Jillian Caiazzi,Rachael Miller,Chantal Furguson,Ellen Sapp,Hassan Fakih,Qi Tan,Nozomi Yamada,Raymond C Furgal,Joseph Paquette,Brianna Bramato,Nicholas McHugh,Ashley Summers,Clemens Lochmann,Bruno M D C Godinho,Samuel Hildebrand,Dimas Echeverria,Matthew R Hassler,Julia F Alterman,Marian DiFiglia,Neil Aronin,Anastasia Khvorova
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues
Saturday, May 27, 2023
Author(s):
Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Friday, May 19, 2023
Author(s):
Kyounghee Min,Batuhan Yenilmez,Mark Kelly,Dimas Echeverria,Michael Elleby,Lawrence M Lifshitz,Naideline Raymond,Emmanouela Tsagkaraki,Shauna M Harney,Chloe DiMarzio,Hui Wang,Nicholas McHugh,Brianna Bramato,Brett Morrision,Jeffery D Rothstein,Anastasia Khvorova,Michael P Czech
Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease
Saturday, May 13, 2023
Author(s):
Daniel O'Reilly,Jillian Belgrad,Chantal Ferguson,Ashley Summers,Ellen Sapp,Cassandra McHugh,Ella Mathews,Adel Boudi,Julianna Buchwald,Socheata Ly,Dimas Moreno,Raymond Furgal,Eric Luu,Zachary Kennedy,Vignesh Hariharan,Kathryn Monopoli,X William Yang,Jeffery Carroll,Marian DiFiglia,Neil Aronin,Anastasia Khvorova
Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
Monday, May 08, 2023
Author(s):
Jianjun Zhong,Georgia Gunner,Nils Henninger,Dorothy P Schafer,Daryl A Bosco
Current insights into the role of citrullination in thrombosis
Saturday, May 06, 2023
Author(s):
R Madison Green,Paul R Thompson
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope
Wednesday, May 03, 2023
Author(s):
Nathan Bamidele,Han Zhang,Xiaolong Dong,Nicholas Gaston,Haoyang Cheng,Karen Kelly,Jonathan K Watts,Jun Xie,Guangping Gao,Erik J Sontheimer
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors
Friday, April 14, 2023
Author(s):
Samuel R Hildebrand,Adam K Hedger,Ken Yamada,Jonathan K Watts,Anastasia Khvorova
Double Click: Unexpected 1:2 Stoichiometry in a Norbornene-Tetrazine Reaction
Friday, April 14, 2023
Author(s):
Gitali Devi,Adam K Hedger,Richard J Whitby,Jonathan K Watts
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo
Thursday, March 30, 2023
Author(s):
Han Zhang,Karen Kelly,Jonathan Lee,Dimas Echeverria,David Cooper,Rebecca Panwala,Zexiang Chen,Nicholas Gaston,Gregory A Newby,Jun Xie,David R Liu,Guangping Gao,Scot A Wolfe,Anastasia Khvorova,Jonathan K Watts,Erik J Sontheimer
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses
Thursday, March 30, 2023
Author(s):
Sarah N Zvornicanin,Ala M Shaqra,Qiuyu J Huang,Elizabeth Ornelas,Mallika Moghe,Mark Knapp,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Nese Kurt Yilmaz
A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder
Wednesday, March 29, 2023
Author(s):
Joseph Magrino,Veridiana Munford,Davi Jardim Martins,Thais K Homma,Brendan Page,Christl Gaubitz,Bruna L Freire,Antonio M Lerario,Juliana Brandstetter Vilar,Antonio Amorin,Emília K E Leão,Fernando Kok,Carlos Fm Menck,Alexander Al Jorge,Brian A Kelch
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
Thursday, March 09, 2023
Author(s):
Vignesh N Hariharan,Minwook Shin,Ching-Wen Chang,Daniel O'Reilly,Annabelle Biscans,Ken Yamada,Zhiru Guo,Mohan Somasundaran,Qi Tang,Kathryn Monopoli,Pranathi Meda Krishnamurthy,Gitali Devi,Nicholas McHugh,David A Cooper,Dimas Echeverria,John Cruz,Io Long Chan,Ping Liu,Sun-Young Lim,Jill McConnell,Satya Prakash Singh,Samuel Hildebrand,Jacquelyn Sousa,Sarah M Davis,Zachary Kennedy,Chantal Ferguson,Bruno M D C Godinho,Yann Thillier,Jillian Caiazzi,Socheata Ly,Manish Muhuri,Karen Kelly,Fiachra Humphries,Alyssa Cousineau,Krishna Mohan Parsi,Qi Li,Yang Wang,René Maehr,Guangping Gao,Dmitry Korkin,William M McDougall,Robert W Finberg,Katherine A Fitzgerald,Jennifer P Wang,Jonathan K Watts,Anastasia Khvorova
Red light-driven electron sacrificial agents-free photoreduction of inert aryl halides via triplet-triplet annihilation
Monday, February 27, 2023
Author(s):
Le Zeng,Ling Huang,Wenhai Lin,Lin-Han Jiang,Gang Han
Community-developed checklists for publishing images and image analyses
Friday, February 24, 2023
Author(s):
Christopher Schmied,Michael S Nelson,Sergiy Avilov,Gert-Jan Bakker,Cristina Bertocchi,Johanna Bischof,Ulrike Boehm,Jan Brocher,Mariana Carvalho,Catalin Chiritescu,Jana Christopher,Beth A Cimini,Eduardo Conde-Sousa,Michael Ebner,Rupert Ecker,Kevin Eliceiri,Julia Fernandez-Rodriguez,Nathalie Gaudreault,Laurent Gelman,David Grunwald,Tingting Gu,Nadia Halidi,Mathias Hammer,Matthew Hartley,Marie Held,Florian Jug,Varun Kapoor,Ayse Aslihan Koksoy,Judith Lacoste,Sylvia Le Dévédec,Sylvie Le Guyader,Penghuan Liu,Gabriel G Martins,Aastha Mathur,Kota Miura,Paula Montero Llopis,Roland Nitschke,Alison North,Adam C Parslow,Alex Payne-Dwyer,Laure Plantard,Rizwan Ali,Britta Schroth-Diez,Lucas Schütz,Ryan T Scott,Arne Seitz,Olaf Selchow,Ved P Sharma,Martin Spitaler,Sathya Srinivasan,Caterina Strambio-De-Castillia,Douglas Taatjes,Christian Tischer,Helena Klara Jambor
Molecular Magnetic Resonance Imaging of Aneurysmal Inflammation Using a Redox Active Iron Complex
Thursday, February 23, 2023
Author(s):
Robert M King,Matthew J Gounis,Eric J Schmidt,Anita Leporati,Eric M Gale,Alexei A Bogdanov
Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans
Wednesday, February 22, 2023
Author(s):
Nicholas D Peterson,Samantha Y Tse,Qiuyu Judy Huang,Khursheed A Wani,Celia A Schiffer,Read Pukkila-Worley
Conformational dynamics control assembly of an extremely long bacteriophage tail tube
Wednesday, February 15, 2023
Author(s):
Emily Agnello,Joshua Pajak,Xingchen Liu,Brian A Kelch
Tet-Regulated Expression and Optical Clearing for In Vivo Visualization of Genetically Encoded Chimeric dCas9/Fluorescent Protein Probes
Saturday, February 11, 2023
Author(s):
Liliya Maloshenok,Gerel Abushinova,Natalia Kazachkina,Alexei Bogdanov,Victoria Zherdeva
p53 controls choice between apoptotic and non-apoptotic death following DNA damage
Monday, January 30, 2023
Author(s):
Megan E Honeywell,Marie S Isidor,Nicholas W Harper,Rachel E Fontana,Peter Cruz-Gordillo,Sydney A Porto,Cameron S Fraser,Kristopher A Sarosiek,David A Guertin,Jessica B Spinelli,Michael J Lee
Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies
Monday, January 23, 2023
Author(s):
Meenakshi Sundaram Kumar,Karly M Stallworth,Anastasia C Murthy,Su Min Lim,Nan Li,Aastha Jain,James B Munro,Nicolas L Fawzi,Clotilde Lagier-Tourenne,Daryl A Bosco
Metal-Free Far-Red Light-Driven Photolysis via Triplet Fusion to Enhance Checkpoint Blockade Immunotherapy
Thursday, January 12, 2023
Author(s):
Le Zeng,Lin-Han Jiang,Jia-Yao Li,Ling Huang,Yongzhi Chen,Nuo Yu,Lei Wang,Kai Huang,Jing Peng,Gang Han
Chemically Crosslinked Amphiphilic Degradable Shape Memory Polymer Nanocomposites with Readily Tuned Physical, Mechanical, and Biological Properties
Friday, January 06, 2023
Author(s):
Xiaowen Xu,Jordan D Skelly,Jie Song
Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons
Friday, December 23, 2022
Author(s):
Meenakshi Sundaram Kumar,Megan E Fowler-Magaw,Daniel Kulick,Sivakumar Boopathy,Del Hayden Gadd,Melissa Rotunno,Catherine Douthwright,Diane Golebiowski,Issa Yusuf,Zuoshang Xu,Robert H Brown,Miguel Sena-Esteves,Alison L O'Neil,Daryl A Bosco
Consensus Guidelines for the Design and In Vitro Preclinical Efficacy Testing N-of-1 Exon Skipping Antisense Oligonucleotides
Wednesday, December 14, 2022
Author(s):
Annemieke Aartsma-Rus,Alejandro Garanto,Willeke van Roon-Mom,Erin M McConnell,Victoria Suslovitch,Winston X Yan,Jonathan K Watts,Timothy W Yu
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects
Tuesday, December 13, 2022
Author(s):
Feng Wang,Ezequiel Calvo-Roitberg,Julia M Rembetsy-Brown,Minggang Fang,Jacquelyn Sousa,Zachary J Kartje,Pranathi Meda Krishnamurthy,Jonathan Lee,Michael R Green,Athma A Pai,Jonathan K Watts
A reference human induced pluripotent stem cell line for large-scale collaborative studies
Friday, December 02, 2022
Author(s):
Caroline B Pantazis,Andrian Yang,Erika Lara,Justin A McDonough,Cornelis Blauwendraat,Lirong Peng,Hideyuki Oguro,Jitendra Kanaujiya,Jizhong Zou,David Sebesta,Gretchen Pratt,Erin Cross,Jeffrey Blockwick,Philip Buxton,Lauren Kinner-Bibeau,Constance Medura,Christopher Tompkins,Stephen Hughes,Marianita Santiana,Faraz Faghri,Mike A Nalls,Daniel Vitale,Shannon Ballard,Yue A Qi,Daniel M Ramos,Kailyn M Anderson,Julia Stadler,Priyanka Narayan,Jason Papademetriou,Luke Reilly,Matthew P Nelson,Sanya Aggarwal,Leah U Rosen,Peter Kirwan,Venkat Pisupati,Steven L Coon,Sonja W Scholz,Theresa Priebe,Miriam Öttl,Jian Dong,Marieke Meijer,Lara J M Janssen,Vanessa S Lourenco,Rik van der Kant,Dennis Crusius,Dominik Paquet,Ana-Caroline Raulin,Guojun Bu,Aaron Held,Brian J Wainger,Rebecca M C Gabriele,Jackie M Casey,Selina Wray,Dad Abu-Bonsrah,Clare L Parish,Melinda S Beccari,Don W Cleveland,Emmy Li,Indigo V L Rose,Martin Kampmann,Carles Calatayud Aristoy,Patrik Verstreken,Laurin Heinrich,Max Y Chen,Birgitt Schüle,Dan Dou,Erika L F Holzbaur,Maria Clara Zanellati,Richa Basundra,Mohanish Deshmukh,Sarah Cohen,Richa Khanna,Malavika Raman,Zachary S Nevin,Madeline Matia,Jonas Van Lent,Vincent Timmerman,Bruce R Conklin,Katherine Johnson Chase,Ke Zhang,Salome Funes,Daryl A Bosco,Lena Erlebach,Marc Welzer,Deborah Kronenberg-Versteeg,Guochang Lyu,Ernest Arenas,Elena Coccia,Lily Sarrafha,Tim Ahfeldt,John C Marioni,William C Skarnes,Mark R Cookson,Michael E Ward,Florian T Merkle
Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains
Friday, December 02, 2022
Author(s):
Socheata Ly,Marie-Cécile Didiot,Chantal M Ferguson,Andrew H Coles,Rachael Miller,Kathryn Chase,Dimas Echeverria,Feng Wang,Ghazaleh Sadri-Vakili,Neil Aronin,Anastasia Khvorova
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease
Tuesday, November 29, 2022
Author(s):
Jacqueto Zephyr,Desaboini Nageswara Rao,Colby Johnson,Ala M Shaqra,Ellen A Nalivaika,Aria Jordan,Nese Kurt Yilmaz,Akbar Ali,Celia A Schiffer
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state
Saturday, November 19, 2022
Author(s):
Atanu Maiti,Adam K Hedger,Wazo Myint,Vanivilasini Balachandran,Jonathan K Watts,Celia A Schiffer,Hiroshi Matsuo
Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2
Thursday, November 10, 2022
Author(s):
Santanu Mondal,Yongzhi Chen,Gordon J Lockbaum,Sudeshna Sen,Sauradip Chaudhuri,Archie C Reyes,Jeong Min Lee,Arshia N Kaur,Nadia Sultana,Michael D Cameron,Scott A Shaffer,Celia A Schiffer,Katherine A Fitzgerald,Paul R Thompson
Harnessing nucleic acid technologies for human health on earth and in space
Sunday, November 06, 2022
Author(s):
Samantha L Sarli,Jonathan K Watts
Sterilization of Polymeric Implants: Challenges and Opportunities
Tuesday, November 01, 2022
Author(s):
Chloe K Herczeg,Jie Song
The nuclear bodies conference: Hubs of genomic activity, June 24-28, Western Shore, Nova Scotia, Canada
Wednesday, October 26, 2022
Author(s):
Paul D Kaufman,Sui Huang,Thoru Pederson
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models
Monday, October 03, 2022
Author(s):
Faith Conroy,Rachael Miller,Julia F Alterman,Matthew R Hassler,Dimas Echeverria,Bruno M D C Godinho,Emily G Knox,Ellen Sapp,Jaquelyn Sousa,Ken Yamada,Farah Mahmood,Adel Boudi,Kimberly Kegel-Gleason,Marian DiFiglia,Neil Aronin,Anastasia Khvorova,Edith L Pfister
Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB
Saturday, October 01, 2022
Author(s):
Karina Jouravleva,Dmitrij Golovenko,Gabriel Demo,Robert C Dutcher,Traci M Tanaka Hall,Phillip D Zamore,Andrei A Korostelev
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants
Thursday, September 29, 2022
Author(s):
Qi Li,Fiachra Humphries,Roxie C Girardin,Aaron Wallace,Monir Ejemel,Alla Amcheslavsky,Conor T McMahon,Zachary A Schiller,Zepei Ma,John Cruz,Alan P Dupuis,Anne F Payne,Arooma Maryam,Nese Kurt Yilmaz,Kathleen A McDonough,Brian G Pierce,Celia A Schiffer,Andrew C Kruse,Mark S Klempner,Lisa A Cavacini,Katherine A Fitzgerald,Yang Wang
Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism
Friday, September 23, 2022
Author(s):
Cédric Diot,Aurian P García-González,Andre F Vieira,Melissa Walker,Megan Honeywell,Hailey Doyle,Olga Ponomarova,Yomari Rivera,Huimin Na,Hefei Zhang,Michael Lee,Carissa P Olsen,Albertha J M Walhout
Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage
Sunday, September 18, 2022
Author(s):
Huilin Li,Mike O'Donnell,Brian Kelch
Nano-optogenetic immunotherapy
Wednesday, September 14, 2022
Author(s):
Kai Huang,Xiaoxuan Liu,Gang Han,Yubin Zhou
Characterization of optical clearing mechanisms in muscle during treatment with glycerol and gadobutrol solutions
Wednesday, September 14, 2022
Author(s):
Hugo F Silva,Inês S Martins,Alexei A Bogdanov,Valery V Tuchin,Luís M Oliveira
Enhancing Triplet-Triplet Annihilation Upconversion: From Molecular Design to Present Applications
Thursday, September 08, 2022
Author(s):
Le Zeng,Ling Huang,Jinfeng Han,Gang Han
Human Microglia-like Cells: Differentiation from Induced Pluripotent Stem Cells and In Vitro Live-cell Phagocytosis Assay using Human Synaptosomes
Monday, September 05, 2022
Author(s):
Salome Funes,Daryl A Bosco
Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts
Wednesday, August 03, 2022
Author(s):
Minwook Shin,Io Long Chan,Yuming Cao,Alisha M Gruntman,Jonathan Lee,Jacquelyn Sousa,Tomás C Rodríguez,Dimas Echeverria,Gitali Devi,Alexandre J Debacker,Michael P Moazami,Pranathi Meda Krishnamurthy,Julia M Rembetsy-Brown,Karen Kelly,Onur Yukselen,Elisa Donnard,Teagan J Parsons,Anastasia Khvorova,Erik J Sontheimer,René Maehr,Manuel Garber,Jonathan K Watts
Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo
Tuesday, August 02, 2022
Author(s):
Annabelle Biscans,Socheata Ly,Nicholas McHugh,David A Cooper,Anastasia Khvorova
CaMKII binds both substrates and activators at the active site
Wednesday, July 13, 2022
Author(s):
Can Özden,Roman Sloutsky,Tomohiro Mitsugi,Nicholas Santos,Emily Agnello,Christl Gaubitz,Joshua Foster,Emily Lapinskas,Edward A Esposito,Takeo Saneyoshi,Brian A Kelch,Scott C Garman,Yasunori Hayashi,Margaret M Stratton
Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector
Monday, July 11, 2022
Author(s):
Han Zhang,Nathan Bamidele,Pengpeng Liu,Ogooluwa Ojelabi,Xin D Gao,Tomás Rodriguez,Haoyang Cheng,Karen Kelly,Jonathan K Watts,Jun Xie,Guangping Gao,Scot A Wolfe,Wen Xue,Erik J Sontheimer
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