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Selected Recent Publications of Michael A. Brehm, PhD

A complete list of published work can be found in My Bibliography

NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity

Aryee KE, Shultz LD, Burzenski LM, Greiner DL, Brehm MA.  J Leukoc Biol. 2023 May 2;113(5):418-433. doi: 10.1093/jleuko/qiac020. PubMed PMID: 36801998

Humanized Mouse Models for Immuno-oncology Research

Chuprin J, Buettner H, Seedhom MO, Greiner DL, Keck JG, Ishikawa F, Shultz LD, Brehm MA.  Nat Rev Clin Oncol. 2023 Mar;20(3):192-206. doi: 10.1038/s41571-022-00721-2. Epub 2023 Jan 12. Review. PubMed PMID: 36635480

Enhanced Development of Functional Human NK Cells in NOD-scid-IL2rg Mice Expressing Human IL15

Aryee KE, Burzenski LM, Yao LC, Keck JG, Greiner DL, Shultz LD, Brehm MA.  FASEB J. 2022 Sep;36(9):e22476. doi: 10.1096/fj.202200045R. PubMed PMID: 35959876; PubMed Central PMCID: PMC9383543

A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome

Ye C, Yang H, Cheng M, Shultz LD, Greiner DL, Brehm MA, Keck JG.  FASEB J2020 Sep;34(9):12963-12975doi: 10.1096/fj.202001203R. Epub 2020 Aug 9. PubMed PMID: 32772418; PubMed Central PMCID: PMC7436391

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA.  Cell Rep. 2020 Jul 14;32(2):107894. doi: 10.1016/j.celrep.2020.107894.PMID: 32668238 

Proteomic and Transcriptional Profiles of Human Stem Cell-Derived Beta Cells Following Enteroviral Challenge

Nyalwidhe JO, Jurczyk A, Satish B, Redick S, Qaisar N, Trombly MI, Vangala P, Racicot R, Bortell R, Harlan DM, Greiner DL, Brehm MA, Nadler JL, Wang JP.  Microorganisms2020 Feb 20;8(2)doi: 10.3390/microorganisms8020295. PubMed PMID: 32093375; PubMed Central PMCID: PMC7074978.

Humanized immune system mouse models: progress, challenges and opportunities

Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M.  Nat Immunol. 2019 Jul;20(7):770-774. doi: 10.1038/s41590-019-0416-z. PMID: 31160798

Humanized mouse models of immunological diseases and precision medicine

Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, Brehm MA.  Mamm Genome. 2019 Jun;30(5-6):123-142. doi: 10.1007/s00335-019-09796-2. Epub 2019 Mar 7. Review. PMID: 30847553

Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression

Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD.  FASEB J. 2019 Mar;33(3):3137-3151. doi: 10.1096/fj.201800636R. Epub 2018 Nov 1. PMID: 30383447

Survival advantage of both human hepatocyte xenografts and genome edited hepatocytes for treatment of alpha-1 antitrypsin deficiency

Borel, F., Q. Tang, G. Gernoux, C. Greer, Z. Wang, A. Barzel, M..A. Kay, L.D. Shultz, D.L. Greiner, T.R. Flotte, M.A. Brehm, and C. Mueller.  Molecular Therapy, 25:2477-2489, 2017

Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics

Kooreman, N.G., P.E. de Almeida, J.P. Stack, R.V. Nelakanti, S. Diecke, N.Y. Shao, R.J. Swijnenburg, V. Sanchez-Freire, E. Matsa, C. Liu, A.J. Connolly, J.F. Hamming, P.H.A. Quax, M.A. Brehm, D.L. Greiner, L.D. Shultz, and J.C. Wu.  Cell Reports 20:1978-1990, 2017