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Selected Recent Publications of Michael A. Brehm, PhD

A complete list of published work can be found in My Bibliography

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA.
Cell Rep. 2020 Jul 14;32(2):107894. doi: 10.1016/j.celrep.2020.107894.PMID: 32668238 

Humanized immune system mouse models: progress, challenges and opportunities

Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M.
Nat Immunol. 2019 Jul;20(7):770-774. doi: 10.1038/s41590-019-0416-z. No abstract available. PMID: 31160798

Humanized mouse models of immunological diseases and precision medicine

Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, Brehm MA.
Mamm Genome. 2019 Jun;30(5-6):123-142. doi: 10.1007/s00335-019-09796-2. Epub 2019 Mar 7. Review. PMID: 30847553

Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression

Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD.
FASEB J. 2019 Mar;33(3):3137-3151. doi: 10.1096/fj.201800636R. Epub 2018 Nov 1. PMID: 30383447

Survival advantage of both human hepatocyte xenografts and genome edited hepatocytes for treatment of alpha-1 antitrypsin deficiency

Borel, F., Q. Tang, G. Gernoux, C. Greer, Z. Wang, A. Barzel, M..A. Kay, L.D. Shultz, D.L. Greiner, T.R. Flotte, M.A. Brehm, and C. Mueller. 
Molecular Therapy, 25:2477-2489, 2017.

Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics

Kooreman, N.G., P.E. de Almeida, J.P. Stack, R.V. Nelakanti, S. Diecke, N.Y. Shao, R.J. Swijnenburg, V. Sanchez-Freire, E. Matsa, C. Liu, A.J. Connolly, J.F. Hamming, P.H.A. Quax, M.A. Brehm, D.L. Greiner, L.D. Shultz, and J.C. Wu. 
Cell Reports 20:1978-1990, 2017.