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Some of Our Current Type 1 Diabetes Research Includes

Specialized Mouse Avatars for Type 1 Diabetes

Reconstructing human type 1 diabetes (T1D), using cells derived from T1D patients, in our novel immunodeficient mouse.  It provides a better understanding about how humans might react to certain factors.

Using Specialized Mouse Models to Determine the Role of Costimulation Pathway Reagents in Human Immune Cells In Vivo

Assessing the role(s) of human T cell costimulation pathway reagents in vivo using our novel mouse models. 

Development and Validation of Novel Mouse Models for Human Stem Cell Therapy

We validate new models of immunodeficient mice by determining the ability of human stem cells to generate functional differentiated human cells and tissues that ameliorate disease in vivo.

From New Models to Novel Therapeutics

Dr. Brehm is co-director with Dale Greiner, PhD, a of a pre-clinical core to advance development & use of human-specific disease models at UMass Chan Medical School.  The Core is collaborating with The Jackson Laboratory (JAX) Precision Genetics Center (JPGC) promoting interactions with clinicians and hospitals, access to patient data & samples, and comprehensive model assessment necessary for generation of models engrafted with human tumors and immune systems for preclinical testing.

Modeling Human Tumor Immunotherapy in NSG Mice


Dale Greiner & Michael Brehm with Leonard Shultz of The Jackson Laboratory
Michael Brehm Type 1 Diabetes Research

In this video Drs. Harlan & Brehm describe the research collaborative to create a stem cell-derived beta cell replacement therapy with a goal of insulin independence for people with T1D