Welcome to the Lab
Our research is focused on utilizing artificial nucleases for efficient targeted genome editing.
Engineering programmable nucleases for the targeted cleavage of a single site within a vertebrate genome for gene therapy applications:
- We are particularly interested in engineering Cas9 systems with improved precision and targeting range - see Nature Methods paper.
- A small writeup of this new technology can be found at UMassMed Now.
Applying programmable nucleases to interrogate gene regulatory networks - Dendritic cell project.
Applying programmable nucleases to understand the influence of chromatin architecture on transcriptional activity - 4D Nucleome project.
Applying programmable nucleases to understand latent HIV genome structure for nuclease-based erradication- HIV project.
Recent Publications and Reagents
The Omega-based B1H binding site selection system Is being distributed through Addgene.