News and Updates
03/22/2024 Andrew Petti presented at the GSBS 3 minutes thesis event.
03/18/2024 Shunqing Liang has a paper accepted by Human Gene Therapy with the Gao lab. Congrats!
03/1/2024 The Xue lab received FARA funding with the Watts, Wolfe and Sontheimer labs.
02/28/2024 Dr. Xue is invited to give a talk at NCI Oncology Model Forum.
09/01/2023 The Xue lab received a GM R01 grant with the Sontheimer lab.
08/17/2023 The Xue lab received a NCI R01 grant.
08/15/2023 Bin Liu and Chunwei Zheng have a paper accepted by Nature Biotechnology (in collaboration with Dr. Erik Sontheimer's group). Congrats!
06/15/2023 Dr. Xue will give an invited talk at the RTI symposium.
06/02/2023 Chunwei Zheng and Bin Liu have a paper in Nat Comms (in collaboration with Dr. Erik Sontheimer's group). Congrats! 
3/20/2023 Shunqing Liang has a 1st author paper accepted by Nature Methods (with the Wolfe lab). 
1/18/2023 Shunqing Liang has a co-1st author paper accepted by Nature Biotechnology (with the Anderson lab).
12/02/2022 Shunqing Liang presented at the CRISPR supergroup meeting.
10/15/2022 Dr. Xue gave an invited a talk at a NCI Conference.
09/10/2022 Tomas, SuetYan and Jordan's paper is published in Hepatology. Congrats!
08/14/2022 Tingting Jiang received a tenure-track faculty position at the Icahn School of Medicine at Mount Sinai. Congrats!
https://labs.icahn.mssm.edu/jianglab/tingting-jiang/
06/22/2022 Dr. Xue is invited to present a talk at the CFF Research Conference.
06/22/2022 Shunqing Liang presented a poster and a short talk at the RTI symposium.
06/03/2022 Jordan Smith received the UMass Chan Chancellor’s Award and the Dean's Award for Outstanding Thesis Research .
06/02/2022 Dr. Xue co-chaired a session at the NIH SCGE meeting.
04/15/2022 Dr. Xue is invited to give a talk at the ASGCT annual meeting.
02/08/2022 Bin Liu and Chunwei Zheng have a paper accepted by Nature Biotechnology (in collaboration with Dr. Erik Sontheimer's group). Congrats!
01/21/2022 Shunqing Liang has a paper in Nat Comms (in collaboration with Dr. Scot Wolfe's group). Congrats!
12/12/2021 Chunwei Zheng has a paper accepted by Molecular Therapy. Congrats!
11/16/2021 Dr. Xue gave a talk at the Molecular Physiology and Biophysics Seminar Series of the Baylor College of Medicine.
10/20/2021 Shunqing Liang has a paper accepted by Molecular Therapy (in collabroation with Dr. Guangping Gao's group). Congrats!
10/20/2021 Tingting Jiang gave a talk at a NIH SCGE meeting.
09/30/2021 Dr. Xue is elected to join the editorial board of Hepatology.
09/02/2021 The Xue lab received UH3 funding of the NIH somatic cell genome editing consortium with the Gao and Anderson labs. 
08/10/2021 The Xue lab received funding of a five-year P01 subproject grant (PI: Dr. Terence Flotte) from NIH/NHLBI.
07/19/2021 Tingting Jiang has a paper accepted by Nature Biotechnology. Congrats!
Jiang T, Zhang XO, Weng Z, Xue W. (2021) Deletion and replacement of long genomic sequences using prime editing. Nature Biotechnology
04/30/2021 Tingting Jiang is awarded with a NIH K99 fellowship. Congrats!
04/27/2021 Shunqing Liang is selected to give a talk at the NIH SCGE conference.
03/16/2021 Dr. Xue gave a talk at the UMass Chan RNA club.
03/08/2021 Shunqing Liang's PE2* paper with Dr. Scot Wolfe's lab is accepted by Nature Communications. Congrats! Link
12/12/2020 Dr. Xue gave an invited talk at the Alpha-1 Foundation 20th Gordon L. Snider Critical Issues Workshop.
11/30/2020 Tingting Jiang's paper is accepted by Hepatology. Congrats!
11/18/2020 Dr. Xue is featured in the UMass Cancer Walk and Run blog. Link
11/11/2020 Dr. Xue gave an invited online talk at the Loyola University.
10/26/2020 Dr. Xue will co-chair a session at the SCBA-Hepatology Division Third CALS Annual Symposium. 10/26/2020 Tingting Jiang received a poster award at the SCBA-Hepatology Division Third CALS Annual Symposium.
05/21/2020 Dr. Xue is promoted to Associate Professor.
04/27/2020 Jordan's paper is accepted by Hepatology. Congrats!
04/02/2020 Tingting Jiang's ABE paper is accepted by Nature Communications. Congrats! This is a great collaboration with Drs. David Liu, Anton McCaffrey, Daniel Anderson, and Martin Mense. Link 03/30/2020 A review paper with Dr. Chun-Qing Song is published in Theranostics. Link
03/20/2020 First virtual defense. Congrats, Jordan!
03/04/2020 Dr. Xue is invited to give a talk at the cystic fibrosis foundation therapeutics lab.
03/04/2020 Jordan Smith is selected to present a talk at the UMass Chan MD/PhD retreat.
02/8/2020 Simon presented a talk at the CRISPR supergroup.
01/24/2020 A News & View article for Chunqing and Tingting's Nature BME paper. Link
01/02/2020 A collaboration paper with Dr. Zhiping Weng's is accepted by Nucleic Acids Research. Tingting Jiang is a coauthor. Congrats!
12/9/2019 Jordan Smith presented a talk at the MD/PhD Physician Scientist Forum.
12/9/2019 Dr. Xue, Tingting and SuetYan attended the NIH SCGE meeting.
10/3/2019 Jordan Smith will present a talk at the UMass Chan IGP seminar series.
9/24/2019 Dr. Xue will present at the UMassmed annual retreat in October.
8/19/2019 Congratulations to Zack Kennedy. "For ALS medical scientist, finding a cure is personal". Farragher, Thomas (2019) Boston Globe.
8/11/2019 A paper led by Jooyoung Lee in the Sontheimer lab is accepted by RNA.
8/9/2019 Ankur and Zack successfully passed PhD defense. Congrats!
7/28/2019 Jordan Smith is selected to present a talk at the UMassmed retreat. Congrats!
7/25/2019 Dr. Xue presented an invited talk at the Society of Chinese Bioscientists in America (SCBA) symposium, Kunming, China.
7/01/2019 Xue lab and Gao lab received a 3 year grant from the Cystic Fibrosis Foundation. Many thanks for the support!
6/28/2019 Xue lab at the RTI symposium. 
6/26/2019 Ankur's co-author paper with the Mercurio lab is accepted by Journal of Cell Science. Congrats! Link
5/27/2019 Suet-Yan and Ankur's paper is accepted by Hepatology. Congrats! Link
5/1/2019 Dr. Xue is invited to give a talk at the SCBA annual meeting.
4/16/2019 Dr. Xue is invited to give a talk at the ASGCT annual meeting.
4/2/2019 Dr. Xue is selected as an editorial board member of the FASEB journal.
4/1/2019 Dr. Xue is selected to serve as a member of the Cancer Gene & Cell Therapy Committee and the Gene & Cell Therapy of Genetic and Metabolic Diseases Committee of the American Society of Gene & Cell Therapy.
3/8/2019 Haiwei, Deniz and Jordan's paper is accepted by Genome Medicine. Congrats! Link
2/18/2019 Jordan Smith received a F30 fellowship from NCI. Congrats!
2/11/2019 Ankur Sheel and Jordan Smith are selected to present short talks at the MCCB cancer retreat. 2/11/2019 Ankur Sheel is selected to present a short talk at the UMass Chan MD/PhD retreat.
1/21/2019 CRISPR–Cas: a tool for cancer research and therapeutics. by Hao Yin, Wen Xue & Daniel Anderson is published by Nature Reviews Clinical Oncology. Link
1/16/2019 Chunqing and Tingting's paper with David Liu and Hao Yin's labs is accepted by Nature biomedical engineering. Congrats!
12/20/2018 A co-authored paper with Dr. Erik Sontheimer is published in Molecular Cell. Link
12/20/2018 A co-authored paper with Drs Scott Lowe and Carol Prives is published in Cell. Link
12/11/2018 Dr. Xue presented at the NIH somatic cell genome editing workshop. 12/01/2018 Xue lab received NIH somatic cell genome editing funding with the Gao lab to improve genome editing techniques. Link
11/09/2018 Dr. Xue presented an invited talk at the SCBA Hepatology Division First Annual Scientific Symposium.
11/05/2018 Jordan and Haiwei's Research Highlight paper is published in Genome Biology. Link
09/21/2018 A collaboration with Dr. Sontheimer's lab is published in Genome Biology. Link
08/27/2018 A collaboration with Dr. Weng's lab is published in PLoS Genetics. Link
08/14/2018 Chunqing's paper is selected as the cover for Human Gene Therapy. Link. A nice editorial by Dr. Flotte. Link.
08/04/2018 Zack Kennedy received a travel grant from the Oligonucleotide Therapeutics Society. Congrats!
07/05/2018 Ankur Sheel received a F30 fellowship from NCI. Congrats!
06/28/2018 Ankur Sheel chaired a session at the RTI symposium.
06/20/2018 UMass cancer walk fundraisers visited the Xue lab. 06/15/2018 Chunqing Song received a faculty position at the Xihu University. Congrats!
06/02/2018 Dan Wang's paper is accepted by Nature Biotechnology. New publication from Xue, Zamore, and Gao labs. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Dan Wang, Jia Li, Chun-Qing Song, Karen Tran, Haiwei Mou, Pei-Hsuan Wu, Phillip W L Tai, Craig A Mendonca, Lingzhi Ren, Blake Y Wang, Qin Su, Dominic J Gessler, Phillip D Zamore, Wen Xue & Guangping Gao. Nat Biotechnol. 2018. Link
05/09/2018 Dr. Xue gave a talk at the Alpha-1 Support day event.
04/05/2018 The Xue lab received funding as part of Dr. Erik Sontheimer's grant from UMASS Center for Clinical and Translational Science (UMCCTS). Many thanks for the support from UMass CCTS. 
03/19/2018 Chunqing's paper with Dr. Flotte is published in Human Gene Therapy. Link
02/14/2018 Chunqing's review article is published in Nature Reviews Gastroenterology & Hepatology. Link
01/01/2018 Dr. Xue is invited to give a talk at the AACR annual meeting, Chicago.
12/11/2017 Chunqing and SuetYan's paper (with Hao Yin, Bob Langer and Dan Andersonon) is accepted by Nature Chemical Biology. Link
11/18/2017 SuetYan gave an invited talk at the RNA Summit meeting, Boston.
08/25/2017 A paper led by Hao Yin, Bob Langer and Dan Andersonon is accepted by Nature Biotechnology. Chunqing, Haiwei and SuetYan in the Xue lab are co-authors. Link
08/02/2017 A paper led by Dr. Xin Wei Wang at NCI is published in Cancer Cell. Link
08/02/2017 Jordan Smith has been selected for the UMass Cancer Biology T32 fellowship. The selection process this year was extremely competitive. Big congrats!
07/03/2017 Dr. Xue is invited to give a talk at the American Association for the Study of Liver Diseases (AASLD) meeting, Washington, DC.
06/14/2017 An editorial @GenomeBiology on how CRISPR induces exon skipping & what does it mean for your experiments. Link
05/01/2017 Haiwei and Jordan's paper is accepted by Genome Biology. Congrats!
04/01/2017 Dr. Xue is invited to give a talk on CRISPR mouse models at the American Gastroenterological Association (AGA) Digestive Disease Week, Chicago.
04/01/2017 Great editorial on @xue_lab's paper in Gastroenterology:Cancer Gene Discovery in Hepatocellular Carcinoma: The CRISPR/CAS9 Accelerator Link
03/20/2017 Haiwei Mou's paper with Dr. Michal Green is published in PNAS. Congrats! Link
02/03/2017 The Xue lab received funding as part of Dr. Robert Brown's grant from the ALS Association to the ALS ONE-Massachusetts Partnership. Many thanks for the great support.
02/01/2017 Zack Kennedy is selected to give a talk at the American Academy of Neurology 69th Annual Meeting.
12/04/2016 Chun-Qing Song, Yingxiang Li and Haiwei Mou's paper on CRISPR screen is accepted by Gastroenterology (impact factor 18). Many thanks to our collaborators: Drs. Zhiping Weng, Xin Wei Wang (NCI), and Snorri Thorgeirsson (NCI). Link Editorial: Cancer Gene Discovery in Hepatocellular Carcinoma: The CRISPR/CAS9 Accelerator 
11/16/2016 UMass cancer walk fundraisers visited the Xue lab.
11/10/2016 Chun-Qing Song is invited to speak at the CRISPR congress meeting. 10/04/2016 Dr. Xue is awarded the 2016 NIH Director's New Innovator Award. Wen's project titled "CRISPR-BASED MODULAR THERAPY FOR PRECISION MEDICINE " is part of a NIH High-Risk, High-Reward Research (HRHR) program supporting highly creative and exceptional scientists with bold approaches to major challenges in biomedical research. This award will be for five years, total about 2.5 millon dollars. For more, please click here.
09/23/2016 The Xue lab receives $250,000 for pediatric cancer research from Hyundai Hope on Wheels. Many thanks for the great support from Hyundai. For more, please click here.
(Kenneth Laferriere helps his son, Kaiden, put a red handprint on the pocket of the new Hyundai Hope on Wheels lab coat given to grant awardee Wen Xue, PhD.)
09/16/2016 The Xue lab was selected to receive a $150,000, 2 years award from The Lung Cancer Research Foundation (LCRF). Many thanks for the continued support from LCRF.
08/19/2016 Dr. Xue presented a short talk at the CSHL meeting GenomeEngineering: The CRISPR/Cas 9 Revolution.
08/10/2016 The Xue lab received a subproject of a five-year P01 grant (PI: Dr. Terence Flotte) from NIH/NHLBI. The Xue lab will receive about 1.5 millon dollars in direct cost to develop new genome editing tools. Many thanks to our collaborators Drs. Terence Flotte, Guangping Gao, Christian Mueller, and Mai ElMallah. For more, please click here.
08-02-2016 New publication from the Xue lab. Ankur Sheel's "in the spotlight" article is online at Cancer Discovery. Big congrats! Many thanks to Dr. Darryl Conte for his great edits. Link
07-18-2016 Dr. Xue will attend American Cancer Society's annual "Making Strides Against Breast Cancer kickoff breakfast" at WPI on July 23rd.
07-06-2016 Dr. Xue was interviewed by Lung Cancer Research Foundation (LCRF). The article will be published in LCRF's annual report.
06-03-2016 Haiwei Mou presented a poster at the 81st Cold Spring Harbor Laboratory Symposium - Targeting Cancer.
05-11-2016 Dr. Xue attended UMass Chan inKNOWvation event, "The Return of Gene Therapy".
04/11/2016 The Xue lab won research grant from UMASS Center for Clinical and Translational Science (UMCCTS) Pilot Award. Many thanks for the support from UMass CCTS.
04/07/2016 The Xue lab won research grant from American Cancer Society. The $791,000 in funds will support studying KRAS inhibition in lung cancer. Many thanks for the support from ACS. For more, please click here. 
03/25/2016 The Xue lab is feasured in a Nature News article about our CRISPR work. Link
03/04/2016 Chun-Qing Song is invited to speak at the Harvard-Yale Symposium IBC Symposium: CRISPR/Cas9 Research Risks Intersection of Science, Safety and Policy.
02/24/2016 Dr. Xue gave a invited talk at the 2nd CRISPR congress meeting.
02/01/2016
NBT paper is online. Therapeutic genome editing by 
combined viral and non-viral delivery of CRISPR system components to the mouse liver.
“This finding really excites us because it makes us think that this is a gene repair system that could be used to treat a range of diseases — not just tyrosinemia but others as well,” says Dr. Daniel Anderson.
“It’s really exciting to see our team develop this new delivery approach for CRISPR, which I believe has the potential to have far-reaching implications,” says Dr. Robert Langer.Image Ernesto del Aguila III/NHGRI
Nat Biotechnology. 2016 Link PDF
CRISPR/Cas9 therapeutic for Tyrosinemia type I delivered to mice (UMass Chan News)
Curing disease by repairing faulty genes (MIT news)
01/20/2016
Dr. Xue is invited to give a talk at the Fourth Symposium on Translational Genomics with a Special Focus on Liver Cancer at NCI.
01/05/2016 Chunqing Song presented at the CRISPR supergroup. Well done!
12-01-2015 A co-authored paper led by Dr. Hao Yin at MIT is accepted by J Hepatology. The title is "Control of liver size by RNAi-mediated multiplex knockdown and its application for discovery of regulatory mechanisms". Link
11-14-2015 Dr. Xue was invited to give a lecture at "The 18th SAPA-NE Scientific Symposium - The New Era of Gene Therapy".
11-07-2015 New publication with Dr. Xin Wei Wang at NCI. Xue W#, Wang XW#. The search for precision models clinically relevant to human liver cancer. Hepatic Oncology. (Editorial) Vol. 2, No. 4, 315-319. (# co-corresponding authors) Link
10-29-2015 Dr. Xue received Award from Dr. Jan Baranski, Director of Scientific Programs of LCRF at the 10th Annual Lung Cancer Awareness Luncheon in NYC. "The LCRF Scientific Merit Award acknowledges the investigator whose proposal was selected for outstanding overall merit by the Foundation's Scientific Advisory Board. Dr. Xue received the accolade for his research targeting small RNA-mediated KRAS inhibition in lung cancer". News Release
Quote from LCRF: "Among those newly awarded is Wen Xue, PhD, assistant professor at the RNA Therapeutics Institute at the University of Massachusetts Medical School. Dr. Xue also received the LCRF Scientific Merit Award, which acknowledges the investigator whose proposal was selected for outstanding overall merit by the Foundation's Scientific Advisory Board. Dr. Xue received the accolade for his research targeting small RNA-mediated KRAS inhibition in lung cancer. "Continued support for lung cancer research is critical to driving advancements in the field. I'm thankful to LCRF for believing in this important research, which will potentially lead to better patient outcomes." said Dr. Xue. "
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Li Y*, Park A*, Mou H*, Colpan C, Bizhanova A, Akama-Garren E, Joshi N, Hendrickson EA, Feldser D, Yin H, Anderson DG, Jacks T, Weng Z#, Xue W#. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biology, 16(1):111. (# co-corresponding authors) Link
Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes C, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie J, Jacks T, Langer R, Anderson DG. Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature. Nano Lett. 2015. Link Li J, Chanrion M, Sawey E, Wang T, Chow E, Tward A, Su Y, Xue W, Lucito R, Zender L, Lowe SW, Bishop JM, Powers S. Reciprocal Interaction of Wnt and RXR-α Pathways in Hepatocyte Development and Hepatocellular Carcinoma. PLoS One. 10(3):e0118480. (2015)
"Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T. Nature. 2014 doi: 10.1038/nature13906"
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