Welcome to the online home of The Watts Group.
What We Do
We work at the interface of synthetic organic chemistry and studies of modulation of gene expression in cells and organisms. We think nucleic acids are about the most amazing molecules out there – what other class of molecule can be synthesized, copied, read and translated? Or which other class of molecule can swap between functional, complex secondary structures and predictable, linear, readable duplex structure? Nucleic acid chemical biology gives us unique opportunities to interact with cellular processes, to treat and diagnose disease. Our goal is to harness chemistry and biology to help make oligonucleotides a major class of drugs.
We have been awarded a grant by the Friedreich’s Ataxia Research Alliance.
Heavily and fully modified CRISPR guides: Our collaborative work with the Sontheimer and Khvorova labs is now online at Nature Communications.
Vivek Sharma’s paper on new GalNAc monomer and cluster reagents has been accepted by Bioconjugate Chemistry. Congratulations, Vivek!