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Welcome to the Thyme Lab!

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What we do

We study how different genes contribute to intellectual disability in neurodevelopmental disorders with a focus on Down syndrome.

How we do it

We conduct large-scale analyses of zebrafish embryos to determine how genes and molecules influence neurodevelopment and function.

Why we do it

There are no effective treatments for most genetic neurodevelopmental disorders.

Research Highlights


Diencephalic and Neuropeptidergic Dysfunction in Zebrafish with Autism Risk Mutations
Mary E.S. Capps, Anna J. MoyerClaire L. ConklinVerdion MartinaEmma G. Torija-OlsonMorgan C. KleinWilliam C. GannawayCaleb C.S. CalhounMichael D. VivianSummer B. Thyme
2024

We generated 27 zebrafish mutants with presumptive protein-truncating mutations or specific missense variants corresponding to autism-risk alleles in 17 human genes.


A single-cell transcriptome atlas of the maturing zebrafish telencephalon
Shristi Pandey, Anna J Moyer, Summer B Thyme
2023

We define the cell types in the zebrafish forebrain across multiple ages and discover how they change between larval and adult stages.


A customizable low-cost system for massively parallel zebrafish behavioral phenotyping
William Joo, Michael D Vivian, Brett J Graham, Edward R Soucy, Summer B Thyme
2021

We provide a detailed construction manual for our home-built zebrafish behavior apparatus, as well as best practices for larval zebrafish behavioral experiments.

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