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Welcome to the Thyme Lab!

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We study how different genes contribute to intellectual disability in neurodevelopmental disorders with a focus on Down syndrome.

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We conduct large-scale analyses of zebrafish embryos to determine how genes and molecules influence neurodevelopment and function.

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There are no effective treatments for most genetic neurodevelopmental disorders.

Research Highlights

A single-cell transcriptome atlas of the maturing zebrafish telencephalon
Shristi Pandey, Anna J Moyer, Summer B Thyme
2023. Genome Research

We define the cell types in the zebrafish forebrain across multiple ages and discover how they change between larval and adult stages.

Diencephalic and Neuropeptidergic Dysfunction in Zebrafish with Autism Risk Mutations
Mary E.S. Capps, Anna J. MoyerClaire L. ConklinVerdion MartinaEmma G. Torija-OlsonMorgan C. KleinWilliam C. GannawayCaleb C.S. CalhounMichael D. VivianSummer B. Thyme
2024. bioRxiv.

We generated 27 zebrafish mutants with presumptive protein-truncating mutations or specific missense variants corresponding to autism-risk alleles in 17 human genes.

A customizable low-cost system for massively parallel zebrafish behavioral phenotyping
William Joo, Michael D Vivian, Brett J Graham, Edward R Soucy, Summer B Thyme
2021. Frontiers in Behavioral Neuroscience

We provide a detailed construction manual for our home-built zebrafish behavior apparatus, as well as best practices for larval zebrafish behavioral experiments.

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