Publications

Publications

1. Shinde, A. B., Nunn, E.R., Wilson, G.A., Chvasta, M.T., Pinette, J.A., Myers, J.W., Peck, S.H., Spinelli, J.B., Zaganjor, E.  Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis. (2023). J Biol Chem, 104635, doi:10.1016/j.jbc.2023.104635 
   
   

2. Godbole, A. A., Gopalan, S., Nguyen, T.K., Munden, A.L., Lui, D.S., Fanelli, M.J., Vo, P., Lewis, C.A., Spinelli, J.B., Fazzio, T.G., Walker, A.K.  S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress. (2023) Elife 12, doi:10.7554/eLife.79511 
   
   

3. Notarangelo, G., Spinelli, JB., Perez, EM., Baker, GJ., Kurmi, K., Elia, I., Stopka, SA., Baquer, G., Lin, J., Golby, AJ., Joshi, S., Baron, HF., Drijvers, JM., Georgiev, P., Ringel, AE., Zaganjor, E., Mcbrayer, SK., Sorger, PK., Sharpe, AH., Wucherpfennig, KW., Satagata, S., Agar, NY., Suva, ML., Haigis, MC. (2022). "Oncometabolite d-2HG alters T cell metabolism to impair CD8(+) T cell function." Science 377(6614): 1519-1529.
   
   

4. Cangelosi AL, Puszynska AM, Roberts JM, Armani A, Nguyen TP, Spinelli JB, Kunchok T, Wang B, Chan SH, Lewis CA, Comb WC, Bell GW, Helman A, Sabatini DM. Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science. 377(6601):47-56 (2022).
   
   
5. Spinelli JB^*, Zaganjor E*. Mitochondrial efficiency directs cell fate. Nature Cell Biology. (2):125-126 (2022).
   * indicates corresponding author
   
   
6. Spinelli JB^*, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM. Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science. 374(6572):1227-1237 (2021).
   * indicates corresponding author
   
   Perspective piece:
   Baksh SC, Finley LWS. Short-circuiting respiration. Science. 374(6572):1196-1197 (2021).  Full Text Link
   
   
7. Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM. Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction. PNAS. 118(4):e2022120118 (2021).
   
   
8. van Gastel N, Spinelli JB, Haigis MC, Scadden DT. Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice. Bioprotocol. 11(19):e4171 (2021).
   
   
9. Zaganjor E, Yoon H, Spinelli JB, Nunn ER, Laurent G, Keskinidis P, Sivaloganathan S, Joshi S, Notarangelo G, Mulei S, Chvasta MT, Tucker SA, Kalafut K, van de Ven RAH, Clish CB, Haigis MC. SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. Cell Reports. 36(2):109345 (2021).
   
   
10. van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 32(3):391-403.e6 (2020).
    
    
11. Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC. PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metab. 32(2):215-228.e7 (2020).
    
    
12. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K,Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. 175(1):101-116.e25 (2018).
    
    
13. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 560(7716):102-106 (2018).
    
    
14. Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nature Cell Biology. 20(7):745-754 (2018).
    
    
15. Gonzalez Herrera KN, Zaganjor E, Ishikawa Y,Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Reports. 22(8):1945-1955 (2018).
    
    
16. Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC. Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. Science. 358(6365):941-946 (2017).
    
    Perspective piece:
    Dang CV. Feeding Frenzy for Cancer Cells. Science. 358(6365):862-863 (2017).
    
    
17. Spinelli JB, Kelley LP, Haigis MC. An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues. Scientific Reports. 7(1):10304 (2017).
    
    
18. Brown KK, Spinelli JB, Asara JM, Toker A.  Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer. Cancer Discovery. (4):391-399 (2017).
    
    
19. Zaganjor E, Spinelli JB, Haigis MC. Strength in numbers: Phosphofructokinase polymerization prevails in the liver. Cell Bio. 216(8):2239-2241 (2017).
    
    
20. Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M,Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC.  Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metabolism. 24(1):104-17 (2016).