Welcome to the Rothstein and Nündel Lab in the Division of Rheumatology

Our Research Focus:

Activation of autoreactive B cells
Nucleic acid sensors in autoimmune and autoinflammatory diseases
FasL regulation of ocular disorders

Representative Publications

Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. (2021) Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 54(6):1137-1153.
Gregory-Ksander M, Marshak-Rothstein A. (2021) The FasLane to ocular pathology-metalloproteinase cleavage of membrane-bound FasL determines FasL function. J Leukoc Biol. Epub ahead of print.
Pawaria S, Nündel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. (2020) Role of Interferon-γ-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting from DNase II Deficiency. Arthritis Rheumatol. 72:359-370.
Nündel K, Mande P, Moses SL, Busto P, Cullen JL, Schmidt MR, Shlomchik MJ, Woodland RT, Marshak-Rothstein A. (2019) Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells. J Immunol. 203:2055-2062.
Motwani M, Pawaria S, Bernier J, Moses S, Henry K, Fang T, Burkly L, Marshak- Rothstein A, and Fitzgerald KA. (2019) Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models. PNAS 16:7941-50.
Gregory-Ksander M, Perez VL, Marshak-Rothstein A, Ksander BR. (2019) Soluble Fas ligand blocks destructive corneal inflammation in mouse models of corneal epithelial debridement and LPS induced keratitis. Exp Eye Res. 179:47-54.

More Publications

Join our Lab

Join us! Postdoctoral and research technician positions available! Please send CV and a list of 3 references to Dr. Ann Marshak-Rothstein or Dr. Kerstin Nündel.

Page Menu