Search Close Search
Search Close Search
Page Menu

Signal Transduction and Cell Cycle Control

The Lab

Pryciak LabExploring signaling mechanisms with a model system

Our research is aimed at understanding how cellular behavior is controlled by external signals. In particular, we study protein kinase regulatory networks that control signal transduction and cell cycle progression. The key molecular components include a MAP kinase cascade and cyclin dependent kinases (CDKs). We investigate these cellular behaviors using budding yeast, Saccharomyces cerevisiae, which provides a model system that is highly amenable to experimentation using genetics, biochemistry, and cell biology. Our studies stress three general topics: What controls the membrane localization of signaling proteins? How does phosphorylation alter protein function? How do kinases choose their substrates?

Research Focus

Royer Lab

Mutual antagonism between signaling and the cell cycle

The yeast pheromone response pathway is a well-studied model for eukaryotic signal transduction. In this system, an extracellular signal activates intracellular signaling via a MAP kinase cascade, triggering responses such as gene expression and cell cycle arrest. Conversely, when cells enter a new division cycle, signaling in this pathway is antagonized by a cyclin-dependent kinase (CDK). Our current projects are focused on the mechanism of this antagonistic control, the basis of specific substrate recognition by cyclin-CDK complexes, and the determinants of functional distinctions among different cyclins.

Read More 




Kobertz Publications
All Publications


Follow our research, stay in touch – join the lab! 

Twitter Feed

Contact Us

Lazare Research Building 822
Campus Map (pdf)

508-856-8756 (office)


Mailing Address:
UMass Chan Medical School
Attn: Dr. Peter Pryciak/BMB Department
364 Plantation St LRB822
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

Read more here

Undergraduates interested in pursuing a PhD at UMass Chan Medical School should apply directly to the Morningside Graduate School of Biomedical Sciences Program.