Signal Transduction and Cell Cycle Control

The Lab

Royer LabExploring signaling mechanisms with a model system

Our research is aimed at understanding how cellular behavior is controlled by such external signals. In particular, we study protein kinase regulatory networks that control signal transduction and cell cycle progression. The key molecular components include a MAP kinase cascade and cyclin dependent kinases (CDKs). We investigate these issues using budding yeast, Saccharomyces cerevisiae, which provides a model system that is highly amenable to experimentation using genetics, biochemistry, and cell biology. Our studies stress three general topics: What controls the membrane localization of signaling proteins? How does phosphorylation alter protein function? How do kinases choose their substrates?

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Research Focus

Royer Lab

Mutual antagonism between signaling and the cell cycle

The yeast pheromone response pathway is a well-studied model for eukaryotic signal transduction. In this system, an extracellular signal activates intracellular signaling via a MAP kinase cascade, triggering responses such as gene expression and cell cycle arrest. Conversely, when cells enter a new division cycle, signaling in this pathway is antagonized by a cyclin-dependent kinase (CDK). Our current projects are focused on the mechanism of this antagonistic control, the basis of specific substrate recognition by cyclin-CDK complexes, and the determinants of functional distinctions among different cyclins.

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Publications

Kobertz Publications

A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry.

Author(s): Bhaduri S, Valk E, Winters MJ, Gruessner B, Loog M, Pryciak PM .

 

All Publications

 

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Contact Us

Office:
Lazare Research Building 822
Campus Map (pdf)

Phone:
508-856-8756 (office)

Email:
Peter.Pryciak@umassmed.edu

Mailing Address:
University of Massachusetts Medical School
Attn: Dr. Peter Pryciak/BMP department
364 Plantation St LRB822
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

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Undergraduates interested in pursuing a PhD at UMass Medical School should apply directly to the Graduate School of Biomedical Sciences Program.