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Chris Gabel, PhD

Talk title: Leveraging a CAPS Mouse Model to Explore Pharmacological Impact of NLRP3 Inhibition

About Dr. Gabel:

Chris Gabel, PhD began his research career as an assistant professor in cell biology at Columbia University studying lysosomal enzyme trafficking. He subsequently transitioned to drug discovery research and spent over 20 combined years seeking to identify novel therapeutics as part of the inflammation drug discovery units at Pfizer and Amgen. While at Pfizer, Chris and his research team pioneered studies aimed at understanding cellular processes involved in regulating posttranslational processing of newly synthesized IL-1β. The lead compound that emerged from this effort was later demonstrated by others to be a selective inhibitor of NLRP3 activation, establishing the druggability of this target. Chris later spent several years working as an independent consultant, during which time he helped to launch NodThera. Chris received his Bachelor of Science in biochemistry from Iowa State University and his PhD in biochemistry from the University of Washington.