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Yuanfei Wu, M.D., Ph.D.

Ph.D.: 2003, Université Paris
Postdoctoral research: UMass Chan Medical School
Office: UMass Chan Medical School
364 Plantation Street, LRB-570-L
Worcester, MA 01605
Phone: 508-856-2831


HIV-1 induces the formation of stable conjugates between infected and non-infected T cells, which is thought to facilitate HIV-1 cell-to-cell transmission. I have found that the RHO family GTPase CDC42, a molecular switch that plays a key role in the establishment of polarity in eukaryotic cells, is critical for efficient HIV-1 spreading in T cell lines and in primary cells. In addition, I have identified the formin-related protein FMNL1, which has been implicated in cell polarity, as an important partner of CDC42 in HIV-1 cell-to-cell transmission.