Search Close Search
Page Menu

Clinical Trials

Skin and Joint Treatments – These investigational drug trials aim to decrease active lupus disease symptoms such as joint inflammation and skin manifestation. During these trials, patients can maintain their background nonbiologic lupus medications.

  1. A Study to Evaluate Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (POETYK SLE-2).
  2. A Study to Evaluate the Efficacy and Safety of BIIB059 (Litifilimab) in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Nonbiologic Lupus Standard of Care (TOPAZ-1).

Biorepository/Lab Research – These studies collect information from biological samples to help researchers learn more about lupus and to help design other studies in the future.

  1. Lupus Nexus Landmark Study: A Prospective Registry and Biorepository
  2. Caricchio Biorepository- Bacterial Curli & Systemic Lupus Erythematosus
  3. Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (“APS ACTION”) International Clinical Database and Repository

Breakthrough Treatments – Recent innovations in immunotherapy have brought forth a type of treatment that programs a patient’s own immune cells to destroy lupus-causing cells. These personal cell therapies are the most promising areas of lupus treatment and can help patients who do not respond to current treatments.

  1. A Phase 1, Open-Label, Multicenter Study of KYV 101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects with Refractory Lupus Nephritis (KYV-101-001)

Click on each image below to expand.

Innovative Clinical Lupus Research/Trials at UMass Chan Lupus Center

Lupus Nexus Landmark Study: A Prospective Registry and Biorepository

Lupus Related Innovative Clinical Trials & Research Studies, Enrollment Opening Soon at UMass Lupus Center